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The following terms were not found in PubMed: MXRA5Y, MXRA5Y
Page 1
Crypt fusion as a homeostatic mechanism in the human colon.
Baker AM, Gabbutt C, Williams MJ, Cereser B, Jawad N, Rodriguez-Justo M, Jansen M, Barnes CP, Simons BD, McDonald SA, Graham TA, Wright NA. Baker AM, et al. Gut. 2019 Nov;68(11):1986-1993. doi: 10.1136/gutjnl-2018-317540. Epub 2019 Mar 14. Gut. 2019. PMID: 30872394 Free PMC article.
We examined whether crypt fusion (the process of two neighbouring crypts fusing into a single daughter crypt) occurs in the human colon. ...CONCLUSIONS: We have provided the evidence that human colonic crypts undergo fusion, …
We examined whether crypt fusion (the process of two neighbouring crypts fusing into a single daughter crypt) oc …
New tricks from an old oncogene: gene fusion and copy number alterations of MYB in human cancer.
Stenman G, Andersson MK, Andrén Y. Stenman G, et al. Cell Cycle. 2010 Aug 1;9(15):2986-95. doi: 10.4161/cc.9.15.12515. Epub 2010 Aug 28. Cell Cycle. 2010. PMID: 20647765 Free PMC article. Review.
However, it was not until recently that clear evidence was presented showing that MYB actually is an oncogene rearranged in human cancer. In a recent study, a novel mechanism of activation of MYB involving gene fusion was identified in carcinomas of the breast and h …
However, it was not until recently that clear evidence was presented showing that MYB actually is an oncogene rearranged in human can …
Cellular protection mechanisms that minimise accumulation of mutations in intestinal tissue.
van Rheenen J, Bruens L. van Rheenen J, et al. Swiss Med Wkly. 2017 Nov 8;147:w14539. doi: 10.4414/smw.2017.14539. eCollection 2017. Swiss Med Wkly. 2017. PMID: 29120019 Free article. Review.
Here, we review three cellular protection mechanisms that protect intestinal tissue against accumulation of somatic mutations: the conveyer belt-like structure, stem cell competition and crypt fusion. We highlight the events that can perturb these cellular protectio …
Here, we review three cellular protection mechanisms that protect intestinal tissue against accumulation of somatic mutations: the conveyer …
Dichotomous roles of claudins as tumor promoters or suppressors: lessons from knockout mice.
Kage H, Flodby P, Zhou B, Borok Z. Kage H, et al. Cell Mol Life Sci. 2019 Dec;76(23):4663-4672. doi: 10.1007/s00018-019-03238-7. Epub 2019 Jul 23. Cell Mol Life Sci. 2019. PMID: 31332482 Free PMC article. Review.
Claudin-4, -11, and -15 knockout mice show increased cell proliferation and/or hyperplasia in urothelium, Sertoli cells, and small intestinal crypts, respectively, possibly a precursor to cancer development. ...Consistent with the tumor suppressive role of claudins shown i …
Claudin-4, -11, and -15 knockout mice show increased cell proliferation and/or hyperplasia in urothelium, Sertoli cells, and small intestina …
Comparison of the patterns of expression of rat intestinal fatty acid binding protein/human growth hormone fusion genes in cultured intestinal epithelial cell lines and in the gut epithelium of transgenic mice.
Rottman JN, Gordon JI. Rottman JN, et al. J Biol Chem. 1993 Jun 5;268(16):11994-2002. J Biol Chem. 1993. PMID: 8505324 Free article.
We have compared and contrasted the transcriptional activity of four fusion genes composed of elements from the 5'-nontranscribed domain of rat Fabpi linked to the human growth hormone gene (I-FABP/hGH) in transgenic mice and in five primate epithelial cell lines de …
We have compared and contrasted the transcriptional activity of four fusion genes composed of elements from the 5'-nontranscribed dom …
Expression of liver fatty acid-binding protein/human growth hormone fusion genes within the enterocyte and enteroendocrine cell populations of fetal transgenic mice.
Roth KA, Rubin DC, Birkenmeier EH, Gordon JI. Roth KA, et al. J Biol Chem. 1991 Mar 25;266(9):5949-54. J Biol Chem. 1991. PMID: 1706343 Free article.
We have used transgenic mice containing liver fatty acid-binding protein/human growth hormone (L-FABP/hGH) fusion genes to begin to define the molecular mechanisms which are responsible for appropriate regional and cell-specific expression of genes in the gut. ...Th …
We have used transgenic mice containing liver fatty acid-binding protein/human growth hormone (L-FABP/hGH) fusion genes to beg …
Expression of R-Spondin 1 in ApcMin/+ Mice Suppresses Growth of Intestinal Adenomas by Altering Wnt and Transforming Growth Factor Beta Signaling.
Lähde M, Heino S, Högström J, Kaijalainen S, Anisimov A, Flanagan D, Kallio P, Leppänen VM, Ristimäki A, Ritvos O, Wu K, Tammela T, Hodder M, Sansom OJ, Alitalo K. Lähde M, et al. Gastroenterology. 2021 Jan;160(1):245-259. doi: 10.1053/j.gastro.2020.09.011. Epub 2020 Sep 14. Gastroenterology. 2021. PMID: 32941878
METHODS: An adeno associated viral vector encoding RSPO1-Fc fusion protein, or control vector, was injected into Apc(Min/+)mice. Their intestinal crypts were isolated and cultured as organoids. which were incubated with or without RSPO1-Fc and an inhibitor of transf …
METHODS: An adeno associated viral vector encoding RSPO1-Fc fusion protein, or control vector, was injected into Apc(Min/+)mice. Thei …
Colorectal cancer through simulation and experiment.
Kershaw SK, Byrne HM, Gavaghan DJ, Osborne JM. Kershaw SK, et al. IET Syst Biol. 2013 Jun;7(3):57-73. doi: 10.1049/iet-syb.2012.0019. IET Syst Biol. 2013. PMID: 24046975 Free PMC article. Review.
Over time, the field has witnessed a transition from solely experimental work to the inclusion of mathematical and computational modelling. The fusion of these disciplines has the potential to provide valuable insights into oncologic processes, but also presents the challe …
Over time, the field has witnessed a transition from solely experimental work to the inclusion of mathematical and computational modelling. …
A Diffusion-like Process Accommodates New Crypts During Clonal Expansion in Human Colonic Epithelium.
Olpe C, Khamis D, Chukanova M, Skoufou-Papoutsaki N, Kemp R, Marks K, Tatton C, Lindskog C, Nicholson A, Brunton-Sim R, Malhotra S, Ten Hoopen R, Stanley R, Winton DJ, Morrissey E. Olpe C, et al. Gastroenterology. 2021 Aug;161(2):548-559.e23. doi: 10.1053/j.gastro.2021.04.035. Epub 2021 Apr 22. Gastroenterology. 2021. PMID: 33895166 Free PMC article.
We define the threshold fission rate at which diffusion fails to accommodate new crypts, which can be exceeded by KRAS activating mutations. CONCLUSIONS: Advantaged gene mutations in KDM6A expand dramatically by crypt fission but not fusion. The crypt …
We define the threshold fission rate at which diffusion fails to accommodate new crypts, which can be exceeded by KRAS activating mut …
The intestinal epithelium and its neoplasms: genetic, cellular and tissue interactions.
Dove WF, Cormier RT, Gould KA, Halberg RB, Merritt AJ, Newton MA, Shoemaker AR. Dove WF, et al. Philos Trans R Soc Lond B Biol Sci. 1998 Jun 29;353(1370):915-23. doi: 10.1098/rstb.1998.0256. Philos Trans R Soc Lond B Biol Sci. 1998. PMID: 9684289 Free PMC article. Review.
With such a set, one can then work, using contemporary mouse genetics, to identify the molecular, cellular and organismal strategies that integrate their functions. Finally, with appropriately phenotyped human families, one can investigate by a candidate approach which mod …
With such a set, one can then work, using contemporary mouse genetics, to identify the molecular, cellular and organismal strategies that in …
74 results