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Year Number of Results
2004 1
2006 1
2007 2
2010 3
2011 2
2012 3
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2014 1
2015 8
2016 6
2017 7
2018 4
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2020 3
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60 results

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Page 1
Folding the Mitochondrial UPR into the Integrated Stress Response.
Anderson NS, Haynes CM. Anderson NS, et al. Among authors: haynes cm. Trends Cell Biol. 2020 Jun;30(6):428-439. doi: 10.1016/j.tcb.2020.03.001. Epub 2020 Apr 2. Trends Cell Biol. 2020. PMID: 32413314 Free PMC article. Review.
The mitochondrial unfolded protein response (UPR(mt)) is a mitochondrial-to-nuclear signaling pathway that maintains mitochondrial proteostasis, mediates signaling between tissues, and regulates organismal aging. ...Here, we review recent research into the mechanism …
The mitochondrial unfolded protein response (UPR(mt)) is a mitochondrial-to-nuclear signaling pathway that maintains mitochondrial pr …
The mitochondrial UPR: mechanisms, physiological functions and implications in ageing.
Shpilka T, Haynes CM. Shpilka T, et al. Among authors: haynes cm. Nat Rev Mol Cell Biol. 2018 Feb;19(2):109-120. doi: 10.1038/nrm.2017.110. Epub 2017 Nov 22. Nat Rev Mol Cell Biol. 2018. PMID: 29165426 Review.
Cells have several mechanisms to assess mitochondrial function and activate a transcriptional response known as the mitochondrial unfolded protein response (UPR(mt)) when mitochondrial integrity and function are impaired. The UPR(mt) promotes cell survival and the recovery …
Cells have several mechanisms to assess mitochondrial function and activate a transcriptional response known as the mitochondrial unfolded p …
Metabolism and the UPR(mt).
Lin YF, Haynes CM. Lin YF, et al. Among authors: haynes cm. Mol Cell. 2016 Mar 3;61(5):677-682. doi: 10.1016/j.molcel.2016.02.004. Mol Cell. 2016. PMID: 26942672 Free PMC article. Review.
During mitochondrial dysfunction or the accumulation of unfolded proteins within mitochondria, cells employ a transcriptional response known as the mitochondrial unfolded protein response (UPR(mt)) to promote cell survival along with the repair and recovery of defec …
During mitochondrial dysfunction or the accumulation of unfolded proteins within mitochondria, cells employ a transcriptional respons …
The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR.
Fiorese CJ, Schulz AM, Lin YF, Rosin N, Pellegrino MW, Haynes CM. Fiorese CJ, et al. Among authors: haynes cm. Curr Biol. 2016 Aug 8;26(15):2037-2043. doi: 10.1016/j.cub.2016.06.002. Epub 2016 Jul 14. Curr Biol. 2016. PMID: 27426517 Free PMC article.
Work in Caenorhabditis elegans has shown that the UPR(mt) is regulated by the transcription factor ATFS-1, which is regulated by organelle partitioning. Normally, ATFS-1 accumulates within mitochondria, but during respiratory chain dysfunction, high levels of reactive oxyg …
Work in Caenorhabditis elegans has shown that the UPR(mt) is regulated by the transcription factor ATFS-1, which is regulated by organelle p …
ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription.
Dai CY, Ng CC, Hung GCC, Kirmes I, Hughes LA, Du Y, Brosnan CA, Ahier A, Hahn A, Haynes CM, Rackham O, Filipovska A, Zuryn S. Dai CY, et al. Among authors: haynes cm. Nat Cell Biol. 2023 Aug;25(8):1111-1120. doi: 10.1038/s41556-023-01192-y. Epub 2023 Jul 17. Nat Cell Biol. 2023. PMID: 37460695
Here in Caenorhabditis elegans, we find that the bZIP transcription factor ATFS-1/Atf5 (refs. (2,3)) regulates this balance in favour of mtDNA repair by localizing to mitochondria and interfering with the assembly of the mitochondrial pre-initiation transcription complex b …
Here in Caenorhabditis elegans, we find that the bZIP transcription factor ATFS-1/Atf5 (refs. (2,3)) regulates this balance in favour of mtD …
The mitokine quest(ion).
Deng P, Haynes CM. Deng P, et al. Among authors: haynes cm. Cell Res. 2016 Dec;26(12):1265-1266. doi: 10.1038/cr.2016.138. Epub 2016 Nov 25. Cell Res. 2016. PMID: 27886169 Free PMC article.
Cells and organisms adapt to mitochondrial dysfunction by activating the mitochondrial unfolded protein response (UPR), which is regulated by mitochondrial-to-nuclear communication; and UPR activation can also be transmitted between different cell types suggesting a role i …
Cells and organisms adapt to mitochondrial dysfunction by activating the mitochondrial unfolded protein response (UPR), which is regulated b …
The mitochondrial unfolded protein response: Signaling from the powerhouse.
Qureshi MA, Haynes CM, Pellegrino MW. Qureshi MA, et al. Among authors: haynes cm. J Biol Chem. 2017 Aug 18;292(33):13500-13506. doi: 10.1074/jbc.R117.791061. Epub 2017 Jul 7. J Biol Chem. 2017. PMID: 28687630 Free PMC article. Review.
Mitochondria are multifaceted and indispensable organelles required for cell performance. Accordingly, dysfunction to mitochondria can result in cellular decline and possibly the onset of disease. ...
Mitochondria are multifaceted and indispensable organelles required for cell performance. Accordingly, dysfunction to mitoc …
LONP-1 and ATFS-1 sustain deleterious heteroplasmy by promoting mtDNA replication in dysfunctional mitochondria.
Yang Q, Liu P, Anderson NS, Shpilka T, Du Y, Naresh NU, Li R, Zhu LJ, Luk K, Lavelle J, Zeinert RD, Chien P, Wolfe SA, Haynes CM. Yang Q, et al. Among authors: haynes cm. Nat Cell Biol. 2022 Feb;24(2):181-193. doi: 10.1038/s41556-021-00840-5. Epub 2022 Feb 14. Nat Cell Biol. 2022. PMID: 35165413 Free PMC article.
The mechanism by which ATFS-1 promotes mtDNA accumulation relative to wild-type mtDNAs is unclear. Here we show that ATFS-1 accumulates in dysfunctional mitochondria. ATFS-1 is absent in healthy mitochondria owing to degradation by the mtDNA-bound protease LONP-1, w …
The mechanism by which ATFS-1 promotes mtDNA accumulation relative to wild-type mtDNAs is unclear. Here we show that ATFS-1 accumulates in d …
Signaling and Regulation of the Mitochondrial Unfolded Protein Response.
Naresh NU, Haynes CM. Naresh NU, et al. Among authors: haynes cm. Cold Spring Harb Perspect Biol. 2019 Jun 3;11(6):a033944. doi: 10.1101/cshperspect.a033944. Cold Spring Harb Perspect Biol. 2019. PMID: 30617048 Free PMC article. Review.
Mitochondrial biogenesis and network health relies on maintenance of protein import pathways and the protein-folding environment. Cell-extrinsic or -intrinsic stressors that challenge mitochondrial proteostasis negatively affect organellar function. ...
Mitochondrial biogenesis and network health relies on maintenance of protein import pathways and the protein-folding environment. Cell …
UPR(mt)-mediated cytoprotection and organismal aging.
Schulz AM, Haynes CM. Schulz AM, et al. Among authors: haynes cm. Biochim Biophys Acta. 2015 Nov;1847(11):1448-56. doi: 10.1016/j.bbabio.2015.03.008. Epub 2015 Apr 7. Biochim Biophys Acta. 2015. PMID: 25857997 Free PMC article. Review.
Thus, a major biomedical goal is to identify and therapeutically manipulate those inherent programs that protect against mitochondrial dysfunction to promote cell survival and organismal health. The mitochondrial unfolded protein response (UPR(mt)) is such a protective tra …
Thus, a major biomedical goal is to identify and therapeutically manipulate those inherent programs that protect against mitochondrial dysfu …
60 results