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Regulated Induced Proximity Targeting Chimeras (RIPTACs): a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells Selectively.
Raina K, Forbes CD, Stronk R, Rappi JP Jr, Eastman KJ, Gerritz SW, Yu X, Li H, Bhardwaj A, Forgione M, Hundt A, King MP, Posner ZM, Denny A, McGovern A, Puleo DE, Garvin E, Chenard R, Zaware N, Mousseau JJ, Macaluso J, Martin M, Bassoli K, Jones K, Garcia M, Howard K, Smith LM, Chen JM, De Leon CA, Hines J, Kayser-Bricker KJ, Crews CM. Raina K, et al. Among authors: de leon ca. bioRxiv [Preprint]. 2023 Jan 2:2023.01.01.522436. doi: 10.1101/2023.01.01.522436. bioRxiv. 2023. PMID: 36711980 Free PMC article. Preprint.
O-GlcNAc modification inhibits the calpain-mediated cleavage of α-synuclein.
Levine PM, De Leon CA, Galesic A, Balana A, Marotta NP, Lewis YE, Pratt MR. Levine PM, et al. Among authors: de leon ca. Bioorg Med Chem. 2017 Sep 15;25(18):4977-4982. doi: 10.1016/j.bmc.2017.04.038. Epub 2017 Apr 29. Bioorg Med Chem. 2017. PMID: 28487126 Free PMC article.