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D-cycloserine or similar physiochemical compounds may be uniquely suited for use in Bacillus anthracis spore decontamination strategies.
Omotade TO, Heffron JD, Klimko CP, Marchand CL, Miller LL, Halasahoris SA, Bozue JA, Welkos SL, Cote CK. Omotade TO, et al. J Appl Microbiol. 2013 Dec;115(6):1343-56. doi: 10.1111/jam.12322. Epub 2013 Aug 30. J Appl Microbiol. 2013. PMID: 23927578 Free article.
We investigated the efficacy of d-cycloserine (DCS), an antibiotic and inhibitor of the spore-associated enzyme (alanine racemase) responsible for converting l-alanine to d-alanine, as a spore germination enhancer and antimicrobial agent. ...CONCLUSIONS: These results furt …
We investigated the efficacy of d-cycloserine (DCS), an antibiotic and inhibitor of the spore-associated enzyme (alanine racemase) responsib …
A microtiter fluorometric assay to detect the germination of Bacillus anthracis spores and the germination inhibitory effects of antibodies.
Welkos SL, Cote CK, Rea KM, Gibbs PH. Welkos SL, et al. J Microbiol Methods. 2004 Feb;56(2):253-65. doi: 10.1016/j.mimet.2003.10.019. J Microbiol Methods. 2004. PMID: 14744454
Spore germination in the presence of several germinants was characterized. Although L-alanine and inosine alone stimulated rapid germination in this assay, a medium containing optimal concentrations of L-alanine, adenosine, and casamino acids gave low background flu …
Spore germination in the presence of several germinants was characterized. Although L-alanine and inosine alone stimulated rapid germ …