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Drug Discov Today. 2013 Dec;18(23-24):1221-7. doi: 10.1016/j.drudis.2013.07.011. Epub 2013 Jul 30.

Fragment-based hit identification: thinking in 3D.

Author information

  • 1College of Life Sciences, Sir James Black Centre, University of Dundee, Dundee DD1 5EH, UK. Electronic address: a.morley@dundee.ac.uk.

Abstract

The identification of high-quality hits during the early phases of drug discovery is essential if projects are to have a realistic chance of progressing into clinical development and delivering marketed drugs. As the pharmaceutical industry goes through unprecedented change, there are increasing opportunities to collaborate via pre-competitive networks to marshal multifunctional resources and knowledge to drive impactful, innovative science. The 3D Fragment Consortium is developing fragment-screening libraries with enhanced 3D characteristics and evaluating their effect on the quality of fragment-based hit identification (FBHI) projects.

Copyright © 2013 Elsevier Ltd. All rights reserved.

PMID:
23906694
[PubMed - indexed for MEDLINE]
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