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Results: 1 to 20 of 93

1.

The R-spondin protein family.

de Lau WB, Snel B, Clevers HC.

Genome Biol. 2012;13(3):242. doi: 10.1186/gb-2012-13-3-242. Review.

PMID:
22439850
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor.

Gong X, Carmon KS, Lin Q, Thomas A, Yi J, Liu Q.

PLoS One. 2012;7(5):e37137. doi: 10.1371/journal.pone.0037137. Epub 2012 May 17.

PMID:
22615920
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

RSPO4 is the major gene in autosomal-recessive anonychia and mutations cluster in the furin-like cysteine-rich domains of the Wnt signaling ligand R-spondin 4.

Brüchle NO, Frank J, Frank V, Senderek J, Akar A, Koc E, Rigopoulos D, van Steensel M, Zerres K, Bergmann C.

J Invest Dermatol. 2008 Apr;128(4):791-6. Epub 2007 Oct 4.

PMID:
17914448
[PubMed - indexed for MEDLINE]
Free Article
4.

Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression.

Nam JS, Turcotte TJ, Smith PF, Choi S, Yoon JK.

J Biol Chem. 2006 May 12;281(19):13247-57. Epub 2006 Mar 16.

PMID:
16543246
[PubMed - indexed for MEDLINE]
Free Article
5.

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.

Carmon KS, Gong X, Lin Q, Thomas A, Liu Q.

Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11452-7. doi: 10.1073/pnas.1106083108. Epub 2011 Jun 21.

PMID:
21693646
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling.

Glinka A, Dolde C, Kirsch N, Huang YL, Kazanskaya O, Ingelfinger D, Boutros M, Cruciat CM, Niehrs C.

EMBO Rep. 2011 Sep 30;12(10):1055-61. doi: 10.1038/embor.2011.175.

PMID:
21909076
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5.

Peng WC, de Lau W, Forneris F, Granneman JC, Huch M, Clevers H, Gros P.

Cell Rep. 2013 Jun 27;3(6):1885-92. doi: 10.1016/j.celrep.2013.06.009.

PMID:
23809763
[PubMed - indexed for MEDLINE]
Free Article
8.

Mutations in the gene encoding the Wnt-signaling component R-spondin 4 (RSPO4) cause autosomal recessive anonychia.

Bergmann C, Senderek J, Anhuf D, Thiel CT, Ekici AB, Poblete-Gutierrez P, van Steensel M, Seelow D, Nürnberg G, Schild HH, Nürnberg P, Reis A, Frank J, Zerres K.

Am J Hum Genet. 2006 Dec;79(6):1105-9. Epub 2006 Oct 17.

PMID:
17186469
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength.

de Lau W, Peng WC, Gros P, Clevers H.

Genes Dev. 2014 Feb 15;28(4):305-16. doi: 10.1101/gad.235473.113. Review.

PMID:
24532711
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

R-spondins in cutaneous biology: nails and cancer.

Blaydon DC, Philpott MP, Kelsell DP.

Cell Cycle. 2007 Apr 15;6(8):895-7. Epub 2007 Apr 9. Review.

PMID:
17426450
[PubMed - indexed for MEDLINE]
Free Article
11.

LGR5 interacts and cointernalizes with Wnt receptors to modulate Wnt/β-catenin signaling.

Carmon KS, Lin Q, Gong X, Thomas A, Liu Q.

Mol Cell Biol. 2012 Jun;32(11):2054-64. doi: 10.1128/MCB.00272-12. Epub 2012 Apr 2.

PMID:
22473993
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.

de Lau W, Barker N, Low TY, Koo BK, Li VS, Teunissen H, Kujala P, Haegebarth A, Peters PJ, van de Wetering M, Stange DE, van Es JE, Guardavaccaro D, Schasfoort RB, Mohri Y, Nishimori K, Mohammed S, Heck AJ, Clevers H.

Nature. 2011 Jul 4;476(7360):293-7. doi: 10.1038/nature10337.

PMID:
21727895
[PubMed - indexed for MEDLINE]
13.

The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia.

Blaydon DC, Ishii Y, O'Toole EA, Unsworth HC, Teh MT, Rüschendorf F, Sinclair C, Hopsu-Havu VK, Tidman N, Moss C, Watson R, de Berker D, Wajid M, Christiano AM, Kelsell DP.

Nat Genet. 2006 Nov;38(11):1245-7. Epub 2006 Oct 15.

PMID:
17041604
[PubMed - indexed for MEDLINE]
14.

The structural basis of R-spondin recognition by LGR5 and RNF43.

Chen PH, Chen X, Lin Z, Fang D, He X.

Genes Dev. 2013 Jun 15;27(12):1345-50. doi: 10.1101/gad.219915.113. Epub 2013 Jun 11.

PMID:
23756651
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Regulation of the follistatin gene by RSPO-LGR4 signaling via activation of the WNT/β-catenin pathway in skeletal myogenesis.

Han XH, Jin YR, Tan L, Kosciuk T, Lee JS, Yoon JK.

Mol Cell Biol. 2014 Feb;34(4):752-64. doi: 10.1128/MCB.01285-13. Epub 2013 Dec 16.

PMID:
24344199
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Structural basis for R-spondin recognition by LGR4/5/6 receptors.

Wang D, Huang B, Zhang S, Yu X, Wu W, Wang X.

Genes Dev. 2013 Jun 15;27(12):1339-44. doi: 10.1101/gad.219360.113. Epub 2013 Jun 11.

PMID:
23756652
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5.

Ruffner H, Sprunger J, Charlat O, Leighton-Davies J, Grosshans B, Salathe A, Zietzling S, Beck V, Therier M, Isken A, Xie Y, Zhang Y, Hao H, Shi X, Liu D, Song Q, Clay I, Hintzen G, Tchorz J, Bouchez LC, Michaud G, Finan P, Myer VE, Bouwmeester T, Porter J, Hild M, Bassilana F, Parker CN, Cong F.

PLoS One. 2012;7(7):e40976. doi: 10.1371/journal.pone.0040976. Epub 2012 Jul 16.

PMID:
22815884
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins.

Schuijers J, Clevers H.

EMBO J. 2012 Jun 13;31(12):2685-96. doi: 10.1038/emboj.2012.149. Epub 2012 May 22. Review.

PMID:
22617424
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

R-spondin1 is essential in sex determination, skin differentiation and malignancy.

Parma P, Radi O, Vidal V, Chaboissier MC, Dellambra E, Valentini S, Guerra L, Schedl A, Camerino G.

Nat Genet. 2006 Nov;38(11):1304-9. Epub 2006 Oct 15.

PMID:
17041600
[PubMed - indexed for MEDLINE]
20.

Cellular signaling and biological functions of R-spondins.

Yoon JK, Lee JS.

Cell Signal. 2012 Feb;24(2):369-77. doi: 10.1016/j.cellsig.2011.09.023. Epub 2011 Oct 1. Review.

PMID:
21982879
[PubMed - indexed for MEDLINE]
Free PMC Article

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