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Results: 1 to 20 of 78

1.

Characterization of the Rac guanine nucleotide exchange factor P-Rex1 in platelets.

Aslan JE, Spencer AM, Loren CP, Pang J, Welch HC, Greenberg DL, McCarty OJ.

J Mol Signal. 2011 Sep 1;6:11. doi: 10.1186/1750-2187-6-11.

PMID:
21884615
[PubMed]
Free PMC Article
2.

Role for the guanine nucleotide exchange factor phosphatidylinositol-3,4,5-trisphosphate-dependent rac exchanger 1 in platelet secretion and aggregation.

Qian F, Le Breton GC, Chen J, Deng J, Christman JW, Wu D, Ye RD.

Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):768-77. doi: 10.1161/ATVBAHA.111.243675. Epub 2011 Dec 29.

PMID:
22207728
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

The guanine-nucleotide-exchange factor P-Rex1 is activated by protein phosphatase 1α.

Barber MA, Hendrickx A, Beullens M, Ceulemans H, Oxley D, Thelen S, Thelen M, Bollen M, Welch HC.

Biochem J. 2012 Apr 1;443(1):173-83. doi: 10.1042/BJ20112078.

PMID:
22242915
[PubMed - indexed for MEDLINE]
Free Article
4.

P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils.

Damoulakis G, Gambardella L, Rossman KL, Lawson CD, Anderson KE, Fukui Y, Welch HC, Der CJ, Stephens LR, Hawkins PT.

J Cell Sci. 2014 Jun 1;127(Pt 11):2589-600. doi: 10.1242/jcs.153049. Epub 2014 Mar 21.

PMID:
24659802
[PubMed - in process]
5.

Lack of a significant role of P-Rex1, a major regulator of macrophage Rac1 activation and chemotaxis, in atherogenesis.

Wang Z, Dong X, Li Z, Smith JD, Wu D.

Prostaglandins Other Lipid Mediat. 2008 Dec;87(1-4):9-13. doi: 10.1016/j.prostaglandins.2008.04.001. Epub 2008 Apr 23.

PMID:
18502673
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils.

Dong X, Mo Z, Bokoch G, Guo C, Li Z, Wu D.

Curr Biol. 2005 Oct 25;15(20):1874-9.

PMID:
16243036
[PubMed - indexed for MEDLINE]
Free Article
7.

Involvement of a Rac activator,P-Rex1, in neurotrophin-derived signaling and neuronal migration.

Yoshizawa M, Kawauchi T, Sone M, Nishimura YV, Terao M, Chihama K, Nabeshima Y, Hoshino M.

J Neurosci. 2005 Apr 27;25(17):4406-19.

PMID:
15858067
[PubMed - indexed for MEDLINE]
Free Article
8.

Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant.

Debreceni B, Gao Y, Guo F, Zhu K, Jia B, Zheng Y.

J Biol Chem. 2004 Jan 30;279(5):3777-86. Epub 2003 Nov 3.

PMID:
14597635
[PubMed - indexed for MEDLINE]
Free Article
9.

P-Rex1 - a multidomain protein that regulates neurite differentiation.

Waters JE, Astle MV, Ooms LM, Balamatsias D, Gurung R, Mitchell CA.

J Cell Sci. 2008 Sep 1;121(Pt 17):2892-903. doi: 10.1242/jcs.030353. Epub 2008 Aug 12.

PMID:
18697831
[PubMed - indexed for MEDLINE]
Free Article
10.

P-Rex1 regulates neutrophil function.

Welch HC, Condliffe AM, Milne LJ, Ferguson GJ, Hill K, Webb LM, Okkenhaug K, Coadwell WJ, Andrews SR, Thelen M, Jones GE, Hawkins PT, Stephens LR.

Curr Biol. 2005 Oct 25;15(20):1867-73.

PMID:
16243035
[PubMed - indexed for MEDLINE]
Free Article
11.

P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses.

Lawson CD, Donald S, Anderson KE, Patton DT, Welch HC.

J Immunol. 2011 Feb 1;186(3):1467-76. doi: 10.4049/jimmunol.1002738. Epub 2010 Dec 22.

PMID:
21178006
[PubMed - indexed for MEDLINE]
Free Article
12.

Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis.

Qin J, Xie Y, Wang B, Hoshino M, Wolff DW, Zhao J, Scofield MA, Dowd FJ, Lin MF, Tu Y.

Oncogene. 2009 Apr 23;28(16):1853-63. doi: 10.1038/onc.2009.30. Epub 2009 Mar 23.

PMID:
19305425
[PubMed - indexed for MEDLINE]
Free PMC Article
13.
14.

Vav1, but not Vav2, contributes to platelet aggregation by CRP and thrombin, but neither is required for regulation of phospholipase C.

Pearce AC, Wilde JI, Doody GM, Best D, Inoue O, Vigorito E, Tybulewicz VL, Turner M, Watson SP.

Blood. 2002 Nov 15;100(10):3561-9.

PMID:
12411320
[PubMed - indexed for MEDLINE]
Free Article
15.

Genetic and pharmacologic evidence that Rac1 GTPase is involved in regulation of platelet secretion and aggregation.

Akbar H, Kim J, Funk K, Cancelas JA, Shang X, Chen L, Johnson JF, Williams DA, Zheng Y.

J Thromb Haemost. 2007 Aug;5(8):1747-55.

PMID:
17663742
[PubMed - indexed for MEDLINE]
16.

Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.

Sosa MS, Lopez-Haber C, Yang C, Wang H, Lemmon MA, Busillo JM, Luo J, Benovic JL, Klein-Szanto A, Yagi H, Gutkind JS, Parsons RE, Kazanietz MG.

Mol Cell. 2010 Dec 22;40(6):877-92. doi: 10.1016/j.molcel.2010.11.029.

PMID:
21172654
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Vav family proteins are required for optimal regulation of PLCgamma2 by integrin alphaIIbbeta3.

Pearce AC, McCarty OJ, Calaminus SD, Vigorito E, Turner M, Watson SP.

Biochem J. 2007 Feb 1;401(3):753-61.

PMID:
17054426
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac.

Welch HC, Coadwell WJ, Ellson CD, Ferguson GJ, Andrews SR, Erdjument-Bromage H, Tempst P, Hawkins PT, Stephens LR.

Cell. 2002 Mar 22;108(6):809-21.

PMID:
11955434
[PubMed - indexed for MEDLINE]
Free Article
19.

Differential sensitivity of P-Rex1 to isoforms of G protein betagamma dimers.

Mayeenuddin LH, McIntire WE, Garrison JC.

J Biol Chem. 2006 Jan 27;281(4):1913-20. Epub 2005 Nov 21.

PMID:
16301321
[PubMed - indexed for MEDLINE]
Free Article
20.

Rational design and applications of a Rac GTPase-specific small molecule inhibitor.

Akbar H, Cancelas J, Williams DA, Zheng J, Zheng Y.

Methods Enzymol. 2006;406:554-65.

PMID:
16472687
[PubMed - indexed for MEDLINE]

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