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Results: 1 to 20 of 177

1.

Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford progeria syndrome cells.

Mehta IS, Eskiw CH, Arican HD, Kill IR, Bridger JM.

Genome Biol. 2011 Aug 12;12(8):R74. doi: 10.1186/gb-2011-12-8-r74.

PMID:
21838864
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition.

Glynn MW, Glover TW.

Hum Mol Genet. 2005 Oct 15;14(20):2959-69. Epub 2005 Aug 26.

PMID:
16126733
[PubMed - indexed for MEDLINE]
Free Article
3.

Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody.

McClintock D, Gordon LB, Djabali K.

Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2154-9. Epub 2006 Feb 6.

PMID:
16461887
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome.

Capell BC, Erdos MR, Madigan JP, Fiordalisi JJ, Varga R, Conneely KN, Gordon LB, Der CJ, Cox AD, Collins FS.

Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12879-84. Epub 2005 Aug 29.

PMID:
16129833
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition.

Marji J, O'Donoghue SI, McClintock D, Satagopam VP, Schneider R, Ratner D, Worman HJ, Gordon LB, Djabali K.

PLoS One. 2010 Jun 15;5(6):e11132. doi: 10.1371/journal.pone.0011132.

PMID:
20559568
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells.

Cao K, Capell BC, Erdos MR, Djabali K, Collins FS.

Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):4949-54. Epub 2007 Mar 14.

PMID:
17360355
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin.

Yang SH, Chang SY, Ren S, Wang Y, Andres DA, Spielmann HP, Fong LG, Young SG.

Hum Mol Genet. 2011 Feb 1;20(3):436-44. doi: 10.1093/hmg/ddq490. Epub 2010 Nov 18.

PMID:
21088111
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

LMNA-associated cardiocutaneous progeria: an inherited autosomal dominant premature aging syndrome with late onset.

Kane MS, Lindsay ME, Judge DP, Barrowman J, Ap Rhys C, Simonson L, Dietz HC, Michaelis S.

Am J Med Genet A. 2013 Jul;161A(7):1599-611. doi: 10.1002/ajmg.a.35971. Epub 2013 May 10.

PMID:
23666920
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Blocking protein farnesylation improves nuclear shape abnormalities in keratinocytes of mice expressing the prelamin A variant in Hutchinson-Gilford progeria syndrome.

Wang Y, Ostlund C, Worman HJ.

Nucleus. 2010 Sep-Oct;1(5):432-9. doi: 10.4161/nucl.1.5.12972.

PMID:
21326826
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Identification of mitochondrial dysfunction in Hutchinson-Gilford progeria syndrome through use of stable isotope labeling with amino acids in cell culture.

Rivera-Torres J, Acín-Perez R, Cabezas-Sánchez P, Osorio FG, Gonzalez-Gómez C, Megias D, Cámara C, López-Otín C, Enríquez JA, Luque-García JL, Andrés V.

J Proteomics. 2013 Oct 8;91:466-77. doi: 10.1016/j.jprot.2013.08.008. Epub 2013 Aug 20.

PMID:
23969228
[PubMed - in process]
11.

Progeria, the nucleolus and farnesyltransferase inhibitors.

Mehta IS, Bridger JM, Kill IR.

Biochem Soc Trans. 2010 Feb;38(Pt 1):287-91. doi: 10.1042/BST0380287.

PMID:
20074076
[PubMed - indexed for MEDLINE]
12.

Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation.

Yang SH, Bergo MO, Toth JI, Qiao X, Hu Y, Sandoval S, Meta M, Bendale P, Gelb MH, Young SG, Fong LG.

Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10291-6. Epub 2005 Jul 12.

PMID:
16014412
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Blocking farnesylation of the prelamin A variant in Hutchinson-Gilford progeria syndrome alters the distribution of A-type lamins.

Wang Y, Ostlund C, Choi JC, Swayne TC, Gundersen GG, Worman HJ.

Nucleus. 2012 Sep-Oct;3(5):452-62. doi: 10.4161/nucl.21675. Epub 2012 Aug 16.

PMID:
22895092
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Neonatal progeria: increased ratio of progerin to lamin A leads to progeria of the newborn.

Reunert J, Wentzell R, Walter M, Jakubiczka S, Zenker M, Brune T, Rust S, Marquardt T.

Eur J Hum Genet. 2012 Sep;20(9):933-7. doi: 10.1038/ejhg.2012.36. Epub 2012 Mar 14.

PMID:
22419169
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Disruption of lamin B1 and lamin B2 processing and localization by farnesyltransferase inhibitors.

Adam SA, Butin-Israeli V, Cleland MM, Shimi T, Goldman RD.

Nucleus. 2013 Mar-Apr;4(2):142-50. doi: 10.4161/nucl.24089. Epub 2013 Mar 1.

PMID:
23475125
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Epidermal expression of the truncated prelamin A causing Hutchinson-Gilford progeria syndrome: effects on keratinocytes, hair and skin.

Wang Y, Panteleyev AA, Owens DM, Djabali K, Stewart CL, Worman HJ.

Hum Mol Genet. 2008 Aug 1;17(15):2357-69. doi: 10.1093/hmg/ddn136. Epub 2008 Apr 28.

PMID:
18442998
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Increased mechanosensitivity and nuclear stiffness in Hutchinson-Gilford progeria cells: effects of farnesyltransferase inhibitors.

Verstraeten VL, Ji JY, Cummings KS, Lee RT, Lammerding J.

Aging Cell. 2008 Jun;7(3):383-93. doi: 10.1111/j.1474-9726.2008.00382.x. Epub 2008 Mar 10.

PMID:
18331619
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment.

Columbaro M, Capanni C, Mattioli E, Novelli G, Parnaik VK, Squarzoni S, Maraldi NM, Lattanzi G.

Cell Mol Life Sci. 2005 Nov;62(22):2669-78.

PMID:
16261260
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Lamin A-linked progerias: is farnesylation the be all and end all?

Smallwood DT, Shackleton S.

Biochem Soc Trans. 2010 Feb;38(Pt 1):281-6. doi: 10.1042/BST0380281.

PMID:
20074075
[PubMed - indexed for MEDLINE]
20.

Increased progerin expression associated with unusual LMNA mutations causes severe progeroid syndromes.

Moulson CL, Fong LG, Gardner JM, Farber EA, Go G, Passariello A, Grange DK, Young SG, Miner JH.

Hum Mutat. 2007 Sep;28(9):882-9.

PMID:
17469202
[PubMed - indexed for MEDLINE]

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