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Results: 1 to 20 of 99

1.

Evidence for natural antisense transcript-mediated inhibition of microRNA function.

Faghihi MA, Zhang M, Huang J, Modarresi F, Van der Brug MP, Nalls MA, Cookson MR, St-Laurent G 3rd, Wahlestedt C.

Genome Biol. 2010;11(5):R56. doi: 10.1186/gb-2010-11-5-r56. Epub 2010 May 27.

PMID:
20507594
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase.

Faghihi MA, Modarresi F, Khalil AM, Wood DE, Sahagan BG, Morgan TE, Finch CE, St Laurent G 3rd, Kenny PJ, Wahlestedt C.

Nat Med. 2008 Jul;14(7):723-30. doi: 10.1038/nm1784. Epub 2008 Jun 29.

PMID:
18587408
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1.

Boissonneault V, Plante I, Rivest S, Provost P.

J Biol Chem. 2009 Jan 23;284(4):1971-81. doi: 10.1074/jbc.M807530200. Epub 2008 Nov 5.

PMID:
18986979
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression.

Hébert SS, Horré K, Nicolaï L, Papadopoulou AS, Mandemakers W, Silahtaroglu AN, Kauppinen S, Delacourte A, De Strooper B.

Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6415-20. doi: 10.1073/pnas.0710263105. Epub 2008 Apr 23.

PMID:
18434550
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.

Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M.

Science. 1999 Oct 22;286(5440):735-41.

PMID:
10531052
[PubMed - indexed for MEDLINE]
Free Article
6.

A novel beta-site amyloid precursor protein cleaving enzyme (BACE) isoform regulated by nonsense-mediated mRNA decay and proteasome-dependent degradation.

Tanahashi H, Tabira T.

Neurosci Lett. 2007 Nov 27;428(2-3):103-8. Epub 2007 Sep 26.

PMID:
17961921
[PubMed - indexed for MEDLINE]
7.

Natural antisense transcripts are co-expressed with sense mRNAs in synaptoneurosomes of adult mouse forebrain.

Smalheiser NR, Lugli G, Torvik VI, Mise N, Ikeda R, Abe K.

Neurosci Res. 2008 Dec;62(4):236-9. doi: 10.1016/j.neures.2008.08.010. Epub 2008 Sep 4.

PMID:
18812194
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Regulatory RNA goes awry in Alzheimer's disease.

St George-Hyslop P, Haass C.

Nat Med. 2008 Jul;14(7):711-2. doi: 10.1038/nm0708-711. No abstract available.

PMID:
18607365
[PubMed - indexed for MEDLINE]
9.

The proteins BACE1 and BACE2 and beta-secretase activity in normal and Alzheimer's disease brain.

Stockley JH, O'Neill C.

Biochem Soc Trans. 2007 Jun;35(Pt 3):574-6. Review.

PMID:
17511655
[PubMed - indexed for MEDLINE]
10.

Regulation of BACE1 by miR-29a/b in a cellular model of Spinocerebellar Ataxia 17.

Roshan R, Ghosh T, Gadgil M, Pillai B.

RNA Biol. 2012 Jun;9(6):891-9. doi: 10.4161/rna.19876. Epub 2012 Jun 1.

PMID:
22664922
[PubMed - indexed for MEDLINE]
11.

The beta-secretase, BACE: a prime drug target for Alzheimer's disease.

Vassar R.

J Mol Neurosci. 2001 Oct;17(2):157-70. Review.

PMID:
11816789
[PubMed - indexed for MEDLINE]
12.

Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region.

Lammich S, Schöbel S, Zimmer AK, Lichtenthaler SF, Haass C.

EMBO Rep. 2004 Jun;5(6):620-5. Epub 2004 May 28.

PMID:
15167888
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1.

Wang WX, Rajeev BW, Stromberg AJ, Ren N, Tang G, Huang Q, Rigoutsos I, Nelson PT.

J Neurosci. 2008 Jan 30;28(5):1213-23. doi: 10.1523/JNEUROSCI.5065-07.2008.

PMID:
18234899
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation.

Zhang X, Zhou K, Wang R, Cui J, Lipton SA, Liao FF, Xu H, Zhang YW.

J Biol Chem. 2007 Apr 13;282(15):10873-80. Epub 2007 Feb 15.

PMID:
17303576
[PubMed - indexed for MEDLINE]
Free Article
15.

BACE1: the beta-secretase enzyme in Alzheimer's disease.

Vassar R.

J Mol Neurosci. 2004;23(1-2):105-14. Review.

PMID:
15126696
[PubMed - indexed for MEDLINE]
16.

BACE1 gene promoter single-nucleotide polymorphisms in Alzheimer's disease.

Zhou W, Cai F, Li Y, Yang GS, O'Connor KD, Holt RA, Song W.

J Mol Neurosci. 2010 Sep;42(1):127-33. doi: 10.1007/s12031-010-9381-6. Epub 2010 May 9.

PMID:
20455082
[PubMed - indexed for MEDLINE]
17.

BACE1 gene promoter is differentially regulated: detection of a novel promoter region for its cell type-specific regulation.

Lahiri DK, Maloney B, Ge YW.

J Mol Neurosci. 2006;28(2):193-210.

PMID:
16679558
[PubMed - indexed for MEDLINE]
18.

Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease.

Rossner S, Sastre M, Bourne K, Lichtenthaler SF.

Prog Neurobiol. 2006 Jun;79(2):95-111. Epub 2006 Aug 14. Review.

PMID:
16904810
[PubMed - indexed for MEDLINE]
19.

Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis.

Zhao J, Fu Y, Yasvoina M, Shao P, Hitt B, O'Connor T, Logan S, Maus E, Citron M, Berry R, Binder L, Vassar R.

J Neurosci. 2007 Apr 4;27(14):3639-49.

PMID:
17409228
[PubMed - indexed for MEDLINE]
Free Article
20.

Astrocytic expression of the Alzheimer's disease beta-secretase (BACE1) is stimulus-dependent.

Hartlage-Rübsamen M, Zeitschel U, Apelt J, Gärtner U, Franke H, Stahl T, Günther A, Schliebs R, Penkowa M, Bigl V, Rossner S.

Glia. 2003 Jan 15;41(2):169-79.

PMID:
12509807
[PubMed - indexed for MEDLINE]

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