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Results: 1 to 20 of 102

1.

Predicting drug side-effects by chemical systems biology.

Tatonetti NP, Liu T, Altman RB.

Genome Biol. 2009;10(9):238. doi: 10.1186/gb-2009-10-9-238. Epub 2009 Sep 2. Review.

PMID:
19723347
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Systems pharmacology of complex diseases.

Hansen J, Zhao S, Iyengar R.

Ann N Y Acad Sci. 2011 Dec;1245:E1-5. doi: 10.1111/j.1749-6632.2011.06382.x. Review.

PMID:
22417173
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Predicting drugs side effects based on chemical-chemical interactions and protein-chemical interactions.

Chen L, Huang T, Zhang J, Zheng MY, Feng KY, Cai YD, Chou KC.

Biomed Res Int. 2013;2013:485034. doi: 10.1155/2013/485034. Epub 2013 Sep 4.

PMID:
24078917
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Drug discovery in the age of systems biology: the rise of computational approaches for data integration.

Iskar M, Zeller G, Zhao XM, van Noort V, Bork P.

Curr Opin Biotechnol. 2012 Aug;23(4):609-16. doi: 10.1016/j.copbio.2011.11.010. Epub 2011 Dec 5. Review.

PMID:
22153034
[PubMed - indexed for MEDLINE]
5.

Systems biology, metabolic modelling and metabolomics in drug discovery and development.

Kell DB.

Drug Discov Today. 2006 Dec;11(23-24):1085-92. Epub 2006 Oct 19. Review.

PMID:
17129827
[PubMed - indexed for MEDLINE]
6.

In silico predictions of ADME/T properties: progress and challenge.

Hou T.

Comb Chem High Throughput Screen. 2011 Jun 1;14(5):306. No abstract available.

PMID:
21470177
[PubMed - indexed for MEDLINE]
7.

Relating protein pharmacology by ligand chemistry.

Keiser MJ, Roth BL, Armbruster BN, Ernsberger P, Irwin JJ, Shoichet BK.

Nat Biotechnol. 2007 Feb;25(2):197-206.

PMID:
17287757
[PubMed - indexed for MEDLINE]
8.

Impact of computational structure-based predictive toxicology in drug discovery.

Mohan CG.

Comb Chem High Throughput Screen. 2011 Jun 1;14(5):417-26. Review.

PMID:
21470184
[PubMed - indexed for MEDLINE]
9.

Mapping drug-target interaction networks.

Tian L, Zhang S.

Conf Proc IEEE Eng Med Biol Soc. 2009;2009:2336-9. doi: 10.1109/IEMBS.2009.5335053.

PMID:
19965180
[PubMed - indexed for MEDLINE]
10.

Structural systems pharmacology: a new frontier in discovering novel drug targets.

Tan H, Ge X, Xie L.

Curr Drug Targets. 2013 Aug;14(9):952-8. Review.

PMID:
23597016
[PubMed - indexed for MEDLINE]
11.

Systems biology in drug safety and metabolism: integration of microarray, real-time PCR and enzyme approaches.

Yengi LG.

Pharmacogenomics. 2005 Mar;6(2):185-92. Review.

PMID:
15882137
[PubMed - indexed for MEDLINE]
12.

Strategies to discover unexpected targets for drugs active at G protein-coupled receptors.

Allen JA, Roth BL.

Annu Rev Pharmacol Toxicol. 2011;51:117-44. doi: 10.1146/annurev-pharmtox-010510-100553. Review.

PMID:
20868273
[PubMed - indexed for MEDLINE]
13.

The resurgence of covalent drugs.

Singh J, Petter RC, Baillie TA, Whitty A.

Nat Rev Drug Discov. 2011 Apr;10(4):307-17. doi: 10.1038/nrd3410. Review.

PMID:
21455239
[PubMed - indexed for MEDLINE]
14.

Molecular recognition and binding free energy calculations in drug development.

Dominy BN.

Curr Pharm Biotechnol. 2008 Apr;9(2):87-95. Review.

PMID:
18393865
[PubMed - indexed for MEDLINE]
15.

The chemical basis of pharmacology.

Keiser MJ, Irwin JJ, Shoichet BK.

Biochemistry. 2010 Dec 7;49(48):10267-76. doi: 10.1021/bi101540g. Epub 2010 Nov 12. Review.

PMID:
21058655
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Molecule-kinase interaction map.

Buolamwini JK, Kamath S.

Nat Biotechnol. 2005 Nov;23(11):1346; author reply 1346-8. No abstract available.

PMID:
16273056
[PubMed - indexed for MEDLINE]
17.

Finding time for allosteric interactions.

Wainer IW.

Nat Biotechnol. 2004 Nov;22(11):1376-7. No abstract available.

PMID:
15529160
[PubMed - indexed for MEDLINE]
18.

Drug discovery using chemical systems biology: identification of the protein-ligand binding network to explain the side effects of CETP inhibitors.

Xie L, Li J, Xie L, Bourne PE.

PLoS Comput Biol. 2009 May;5(5):e1000387. doi: 10.1371/journal.pcbi.1000387. Epub 2009 May 15.

PMID:
19436720
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Computational methods in drug discovery.

Sliwoski G, Kothiwale S, Meiler J, Lowe EW Jr.

Pharmacol Rev. 2013 Dec 31;66(1):334-95. doi: 10.1124/pr.112.007336. Print 2014. Review.

PMID:
24381236
[PubMed - indexed for MEDLINE]
20.

Predicting drug side-effect profiles: a chemical fragment-based approach.

Pauwels E, Stoven V, Yamanishi Y.

BMC Bioinformatics. 2011 May 18;12:169. doi: 10.1186/1471-2105-12-169.

PMID:
21586169
[PubMed - indexed for MEDLINE]
Free PMC Article

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