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Results: 1 to 20 of 133

1.

Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy.

Ubeda JM, Légaré D, Raymond F, Ouameur AA, Boisvert S, Rigault P, Corbeil J, Tremblay MJ, Olivier M, Papadopoulou B, Ouellette M.

Genome Biol. 2008;9(7):R115. doi: 10.1186/gb-2008-9-7-r115. Epub 2008 Jul 18.

PMID:
18638379
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Gene expression modulation is associated with gene amplification, supernumerary chromosomes and chromosome loss in antimony-resistant Leishmania infantum.

Leprohon P, Légaré D, Raymond F, Madore E, Hardiman G, Corbeil J, Ouellette M.

Nucleic Acids Res. 2009 Apr;37(5):1387-99. doi: 10.1093/nar/gkn1069. Epub 2009 Jan 7.

PMID:
19129236
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Role of the locus and of the resistance gene on gene amplification frequency in methotrexate resistant Leishmania tarentolae.

Kündig C, Leblanc E, Papadopoulou B, Ouellette M.

Nucleic Acids Res. 1999 Sep 15;27(18):3653-9.

PMID:
10471733
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Modulation of gene expression in Leishmania drug resistant mutants as determined by targeted DNA microarrays.

Guimond C, Trudel N, Brochu C, Marquis N, El Fadili A, Peytavi R, Briand G, Richard D, Messier N, Papadopoulou B, Corbeil J, Bergeron MG, Légaré D, Ouellette M.

Nucleic Acids Res. 2003 Oct 15;31(20):5886-96.

PMID:
14530437
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Formation of extrachromosomal circular amplicons with direct or inverted duplications in drug-resistant Leishmania tarentolae.

Grondin K, Roy G, Ouellette M.

Mol Cell Biol. 1996 Jul;16(7):3587-95.

PMID:
8668175
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

H DNA amplification in Leishmania resistant to both arsenite and methotrexate.

Katakura K, Chang KP.

Mol Biochem Parasitol. 1989 May 1;34(2):189-91. No abstract available.

PMID:
2710170
[PubMed - indexed for MEDLINE]
7.

A member of the aldoketo reductase family confers methotrexate resistance in Leishmania.

Callahan HL, Beverley SM.

J Biol Chem. 1992 Dec 5;267(34):24165-8.

PMID:
1339441
[PubMed - indexed for MEDLINE]
Free Article
8.

Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica.

Coderre JA, Beverley SM, Schimke RT, Santi DV.

Proc Natl Acad Sci U S A. 1983 Apr;80(8):2132-6.

PMID:
6572966
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Frequent amplification of a short chain dehydrogenase gene as part of circular and linear amplicons in methotrexate resistant Leishmania.

Papadopoulou B, Roy G, Ouellette M.

Nucleic Acids Res. 1993 Sep 11;21(18):4305-12.

PMID:
8414986
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Homologous recombination between direct repeat sequences yields P-glycoprotein containing amplicons in arsenite resistant Leishmania.

Grondin K, Papadopoulou B, Ouellette M.

Nucleic Acids Res. 1993 Apr 25;21(8):1895-901.

PMID:
8098523
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Selection against the dihydrofolate reductase-thymidylate synthase (DHFR-TS) locus as a probe of genetic alterations in Leishmania major.

Gueiros-Filho FJ, Beverley SM.

Mol Cell Biol. 1996 Oct;16(10):5655-63.

PMID:
8816478
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Genome-wide gene expression profiling analysis of Leishmania major and Leishmania infantum developmental stages reveals substantial differences between the two species.

Rochette A, Raymond F, Ubeda JM, Smith M, Messier N, Boisvert S, Rigault P, Corbeil J, Ouellette M, Papadopoulou B.

BMC Genomics. 2008 May 29;9:255. doi: 10.1186/1471-2164-9-255.

PMID:
18510761
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Leishmania gene amplification: a mechanism of drug resistance.

Segovia M.

Ann Trop Med Parasitol. 1994 Apr;88(2):123-30. Review.

PMID:
8067807
[PubMed - indexed for MEDLINE]
14.

Biochemical and genetic tests for inhibitors of Leishmania pteridine pathways.

Hardy LW, Matthews W, Nare B, Beverley SM.

Exp Parasitol. 1997 Nov;87(3):157-69.

PMID:
9371081
[PubMed - indexed for MEDLINE]
15.

Unstable DNA amplifications in methotrexate-resistant Leishmania consist of extrachromosomal circles which relocalize during stabilization.

Beverley SM, Coderre JA, Santi DV, Schimke RT.

Cell. 1984 Sep;38(2):431-9.

PMID:
6467372
[PubMed - indexed for MEDLINE]
16.

A mutant dihydrofolate reductase-thymidylate synthase from Leishmania major as a selectable marker in transfection experiments.

Arrebola R, Olmo A, Camacho A, Ruiz-Pérez LM, González-Pacanowska D.

Mol Biochem Parasitol. 1996 Jul;79(1):129-33. No abstract available.

PMID:
8844682
[PubMed - indexed for MEDLINE]
17.

Proteome mapping of the protozoan parasite Leishmania and application to the study of drug targets and resistance mechanisms.

Drummelsmith J, Brochu V, Girard I, Messier N, Ouellette M.

Mol Cell Proteomics. 2003 Mar;2(3):146-55. Epub 2003 Mar 15.

PMID:
12644573
[PubMed - indexed for MEDLINE]
Free Article
18.

Amplification of the H locus in Leishmania infantum.

Chiquero MJ, Olmo A, Navarro P, Ruiz-Perez LM, Castanys S, Gonzalez-Pacanowska D, Gamarro F.

Biochim Biophys Acta. 1994 Nov 29;1227(3):188-94.

PMID:
7986827
[PubMed - indexed for MEDLINE]
19.

Growth phase regulation of the main folate transporter of Leishmania infantum and its role in methotrexate resistance.

Richard D, Leprohon P, Drummelsmith J, Ouellette M.

J Biol Chem. 2004 Dec 24;279(52):54494-501. Epub 2004 Oct 4.

PMID:
15466466
[PubMed - indexed for MEDLINE]
Free Article
20.

Functional analysis and complex gene rearrangements of the folate/biopterin transporter (FBT) gene family in the protozoan parasite Leishmania.

Ouameur AA, Girard I, Légaré D, Ouellette M.

Mol Biochem Parasitol. 2008 Dec;162(2):155-64. doi: 10.1016/j.molbiopara.2008.08.007. Epub 2008 Aug 29.

PMID:
18796316
[PubMed - indexed for MEDLINE]

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