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Results: 1 to 20 of 83

1.

Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype.

Lobenhofer EK, Auman JT, Blackshear PE, Boorman GA, Bushel PR, Cunningham ML, Fostel JM, Gerrish K, Heinloth AN, Irwin RD, Malarkey DE, Merrick BA, Sieber SO, Tucker CJ, Ward SM, Wilson RE, Hurban P, Tennant RW, Paules RS.

Genome Biol. 2008;9(6):R100. doi: 10.1186/gb-2008-9-6-r100. Epub 2008 Jun 20.

PMID:
18570634
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Correlation of simultaneous differential gene expression in the blood and heart with known mechanisms of adriamycin-induced cardiomyopathy in the rat.

Brown HR, Ni H, Benavides G, Yoon L, Hyder K, Giridhar J, Gardner G, Tyler RD, Morgan KT.

Toxicol Pathol. 2002 Jul-Aug;30(4):452-69.

PMID:
12187937
[PubMed - indexed for MEDLINE]
Free Article
3.

Development of an approach for ab initio estimation of compound-induced liver injury based on global gene transcriptional profiles.

Dai X, He YD, Dai H, Lum PY, Roberts CJ, Waring JF, Ulrich RG.

Genome Inform. 2006;17(2):77-88.

PMID:
17503381
[PubMed - indexed for MEDLINE]
4.

Toxicogenomic analysis of N-nitrosomorpholine induced changes in rat liver: comparison of genomic and proteomic responses and anchoring to histopathological parameters.

Oberemm A, Ahr HJ, Bannasch P, Ellinger-Ziegelbauer H, Glückmann M, Hellmann J, Ittrich C, Kopp-Schneider A, Kramer PJ, Krause E, Kröger M, Kiss E, Richter-Reichhelm HB, Scholz G, Seemann K, Weimer M, Gundert-Remy U.

Toxicol Appl Pharmacol. 2009 Dec 1;241(2):230-45. doi: 10.1016/j.taap.2009.08.020. Epub 2009 Aug 28.

PMID:
19716841
[PubMed - indexed for MEDLINE]
5.

Systems biological responses to chronic perfluorododecanoic acid exposure by integrated metabonomic and transcriptomic studies.

Ding L, Hao F, Shi Z, Wang Y, Zhang H, Tang H, Dai J.

J Proteome Res. 2009 Jun;8(6):2882-91. doi: 10.1021/pr9000256.

PMID:
19378957
[PubMed - indexed for MEDLINE]
6.

Gene expression profiling in rat liver treated with compounds inducing phospholipidosis.

Hirode M, Ono A, Miyagishima T, Nagao T, Ohno Y, Urushidani T.

Toxicol Appl Pharmacol. 2008 Jun 15;229(3):290-9. doi: 10.1016/j.taap.2008.01.036. Epub 2008 Feb 14.

PMID:
18355885
[PubMed - indexed for MEDLINE]
7.

Identification of genomic biomarkers for concurrent diagnosis of drug-induced renal tubular injury using a large-scale toxicogenomics database.

Kondo C, Minowa Y, Uehara T, Okuno Y, Nakatsu N, Ono A, Maruyama T, Kato I, Yamate J, Yamada H, Ohno Y, Urushidani T.

Toxicology. 2009 Nov 9;265(1-2):15-26. doi: 10.1016/j.tox.2009.09.003. Epub 2009 Sep 15.

PMID:
19761811
[PubMed - indexed for MEDLINE]
8.

Gene expression profiling in rat liver treated with various hepatotoxic-compounds inducing coagulopathy.

Hirode M, Omura K, Kiyosawa N, Uehara T, Shimuzu T, Ono A, Miyagishima T, Nagao T, Ohno Y, Urushidani T.

J Toxicol Sci. 2009 Jun;34(3):281-93.

PMID:
19483382
[PubMed - indexed for MEDLINE]
Free Article
9.

Application of visualization tools to the analysis of histopathological data enhances biological insight and interpretation.

Lobenhofer EK, Boorman GA, Phillips KL, Heinloth AN, Malarkey DE, Blackshear PE, Houle C, Hurban P.

Toxicol Pathol. 2006;34(7):921-8.

PMID:
17178692
[PubMed - indexed for MEDLINE]
Free Article
10.

Assessing chronic liver toxicity based on relative gene expression data.

Kulkarni K, Larsen P, Linninger AA.

J Theor Biol. 2008 Sep 21;254(2):308-18. doi: 10.1016/j.jtbi.2008.05.032. Epub 2008 Jul 25.

PMID:
18585395
[PubMed - indexed for MEDLINE]
11.

A toxicogenomics-based parallelogram approach to evaluate the relevance of coumarin-induced responses in primary human hepatocytes in vitro for humans in vivo.

Kienhuis AS, van de Poll MC, Dejong CH, Gottschalk R, van Herwijnen M, Boorsma A, Kleinjans JC, Stierum RH, van Delft JH.

Toxicol In Vitro. 2009 Sep;23(6):1163-9. doi: 10.1016/j.tiv.2009.06.005. Epub 2009 Jun 13.

PMID:
19527782
[PubMed - indexed for MEDLINE]
12.

Toxicogenomic effects common to triazole antifungals and conserved between rats and humans.

Goetz AK, Dix DJ.

Toxicol Appl Pharmacol. 2009 Jul 1;238(1):80-9. doi: 10.1016/j.taap.2009.04.016. Epub 2009 May 3.

PMID:
19409404
[PubMed - indexed for MEDLINE]
13.

Precision-cut organ slices to investigate target organ injury.

Vickers AE, Fisher RL.

Expert Opin Drug Metab Toxicol. 2005 Dec;1(4):687-99. Review.

PMID:
16863433
[PubMed - indexed for MEDLINE]
14.

Toxicogenomics: transcription profiling for toxicology assessment.

Zhou T, Chou J, Watkins PB, Kaufmann WK.

EXS. 2009;99:325-66. Review.

PMID:
19157067
[PubMed - indexed for MEDLINE]
15.
16.

Global gene expression in rat brain and liver after oral exposure to the explosive hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX).

Bannon DI, Dillman JF, Hable MA, Phillips CS, Perkins EJ.

Chem Res Toxicol. 2009 Apr;22(4):620-5. doi: 10.1021/tx800444k.

PMID:
19239275
[PubMed - indexed for MEDLINE]
17.

Discriminating different classes of toxicants by transcript profiling.

Steiner G, Suter L, Boess F, Gasser R, de Vera MC, Albertini S, Ruepp S.

Environ Health Perspect. 2004 Aug;112(12):1236-48.

PMID:
15345370
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Use of toxicogenomics to understand mechanisms of drug-induced hepatotoxicity during drug discovery and development.

Blomme EA, Yang Y, Waring JF.

Toxicol Lett. 2009 Apr 10;186(1):22-31. doi: 10.1016/j.toxlet.2008.09.017. Epub 2008 Oct 17. Review.

PMID:
18996174
[PubMed - indexed for MEDLINE]
19.

Use of transcriptomics in understanding mechanisms of drug-induced toxicity.

Cui Y, Paules RS.

Pharmacogenomics. 2010 Apr;11(4):573-85. doi: 10.2217/pgs.10.37. Review.

PMID:
20350139
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

The introduction of toxicogenomics; potential new markers of hepatotoxicity.

Heijne WH, Stierum RH, Leeman WR, van Ommen B.

Cancer Biomark. 2005;1(1):41-57. Review. No abstract available.

PMID:
17192031
[PubMed - indexed for MEDLINE]

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