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Results: 1 to 20 of 111

1.

The Janus kinases (Jaks).

Yamaoka K, Saharinen P, Pesu M, Holt VE 3rd, Silvennoinen O, O'Shea JJ.

Genome Biol. 2004;5(12):253. Epub 2004 Nov 30. Review.

PMID:
15575979
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

JAKs in pathology: role of Janus kinases in hematopoietic malignancies and immunodeficiencies.

Vainchenker W, Dusa A, Constantinescu SN.

Semin Cell Dev Biol. 2008 Aug;19(4):385-93. doi: 10.1016/j.semcdb.2008.07.002. Epub 2008 Jul 17. Review.

PMID:
18682296
[PubMed - indexed for MEDLINE]
3.

CXCL12 signaling is independent of Jak2 and Jak3.

Moriguchi M, Hissong BD, Gadina M, Yamaoka K, Tiffany HL, Murphy PM, Candotti F, O'Shea JJ.

J Biol Chem. 2005 Apr 29;280(17):17408-14. Epub 2004 Dec 20.

PMID:
15611059
[PubMed - indexed for MEDLINE]
Free Article
4.

Janus kinases and their role in growth and disease.

Aringer M, Cheng A, Nelson JW, Chen M, Sudarshan C, Zhou YJ, O'Shea JJ.

Life Sci. 1999;64(24):2173-86. Review.

PMID:
10374907
[PubMed - indexed for MEDLINE]
5.

Jaks and cytokine receptors--an intimate relationship.

Haan C, Kreis S, Margue C, Behrmann I.

Biochem Pharmacol. 2006 Nov 30;72(11):1538-46. Epub 2006 Apr 27. Review.

PMID:
16750817
[PubMed - indexed for MEDLINE]
6.

Cross-regulation of JAK and Src kinases.

Ingley E, Klinken SP.

Growth Factors. 2006 Mar;24(1):89-95. Review.

PMID:
16393697
[PubMed - indexed for MEDLINE]
7.

A region encompassing the FERM domain of Jak1 is necessary for binding to the cytokine receptor gp130.

Hilkens CM, Is'harc H, Lillemeier BF, Strobl B, Bates PA, Behrmann I, Kerr IM.

FEBS Lett. 2001 Sep 7;505(1):87-91.

PMID:
11557047
[PubMed - indexed for MEDLINE]
Free Article
8.

Dual role of the Jak1 FERM and kinase domains in cytokine receptor binding and in stimulation-dependent Jak activation.

Haan S, Margue C, Engrand A, Rolvering C, Schmitz-Van de Leur H, Heinrich PC, Behrmann I, Haan C.

J Immunol. 2008 Jan 15;180(2):998-1007.

PMID:
18178840
[PubMed - indexed for MEDLINE]
Free Article
9.

Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases.

Zhou YJ, Chen M, Cusack NA, Kimmel LH, Magnuson KS, Boyd JG, Lin W, Roberts JL, Lengi A, Buckley RH, Geahlen RL, Candotti F, Gadina M, Changelian PS, O'Shea JJ.

Mol Cell. 2001 Nov;8(5):959-69.

PMID:
11741532
[PubMed - indexed for MEDLINE]
Free Article
10.

Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains.

Williams NK, Bamert RS, Patel O, Wang C, Walden PM, Wilks AF, Fantino E, Rossjohn J, Lucet IS.

J Mol Biol. 2009 Mar 20;387(1):219-32. doi: 10.1016/j.jmb.2009.01.041. Epub 2009 Jan 29.

PMID:
19361440
[PubMed - indexed for MEDLINE]
11.

Autosomal SCID caused by a point mutation in the N-terminus of Jak3: mapping of the Jak3-receptor interaction domain.

Cacalano NA, Migone TS, Bazan F, Hanson EP, Chen M, Candotti F, O'Shea JJ, Johnston JA.

EMBO J. 1999 Mar 15;18(6):1549-58.

PMID:
10075926
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Molecular modeling of the Jak3 kinase domains and structural basis for severe combined immunodeficiency.

Vihinen M, Villa A, Mella P, Schumacher RF, Savoldi G, O'Shea JJ, Candotti F, Notarangelo LD.

Clin Immunol. 2000 Aug;96(2):108-18.

PMID:
10900158
[PubMed - indexed for MEDLINE]
13.

JAK protein kinase inhibitors.

Thompson JE.

Drug News Perspect. 2005 Jun;18(5):305-10. Review.

PMID:
16193102
[PubMed - indexed for MEDLINE]
14.

Determination of the transphosphorylation sites of Jak2 kinase.

Matsuda T, Feng J, Witthuhn BA, Sekine Y, Ihle JN.

Biochem Biophys Res Commun. 2004 Dec 10;325(2):586-94.

PMID:
15530433
[PubMed - indexed for MEDLINE]
15.

Mapping of a region within the N terminus of Jak1 involved in cytokine receptor interaction.

Haan C, Is'harc H, Hermanns HM, Schmitz-Van De Leur H, Kerr IM, Heinrich PC, Grötzinger J, Behrmann I.

J Biol Chem. 2001 Oct 5;276(40):37451-8. Epub 2001 Jul 23.

PMID:
11468294
[PubMed - indexed for MEDLINE]
Free Article
16.

Prediction of the structure of human Janus kinase 2 (JAK2) comprising JAK homology domains 1 through 7.

Giordanetto F, Kroemer RT.

Protein Eng. 2002 Sep;15(9):727-37.

PMID:
12456871
[PubMed - indexed for MEDLINE]
Free Article
17.

Jak family of kinases in cancer.

Verma A, Kambhampati S, Parmar S, Platanias LC.

Cancer Metastasis Rev. 2003 Dec;22(4):423-34. Review.

PMID:
12884916
[PubMed - indexed for MEDLINE]
18.

Mutations in severe combined immune deficiency (SCID) due to JAK3 deficiency.

Notarangelo LD, Mella P, Jones A, de Saint Basile G, Savoldi G, Cranston T, Vihinen M, Schumacher RF.

Hum Mutat. 2001 Oct;18(4):255-63. Review.

PMID:
11668610
[PubMed - indexed for MEDLINE]
19.

Advances in the understanding of cytokine signal transduction: the role of Jaks and STATs in immunoregulation and the pathogenesis of immunodeficiency.

O'Shea JJ, Notarangelo LD, Johnston JA, Candotti F.

J Clin Immunol. 1997 Nov;17(6):431-47. Review.

PMID:
9418183
[PubMed - indexed for MEDLINE]
20.

Signaling through the hematopoietic cytokine receptors.

Ihle JN, Witthuhn BA, Quelle FW, Yamamoto K, Silvennoinen O.

Annu Rev Immunol. 1995;13:369-98. Review.

PMID:
7612228
[PubMed - indexed for MEDLINE]

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