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PTPN22 alters the development of regulatory T cells in the thymus.

Maine CJ, Hamilton-Williams EE, Cheung J, Stanford SM, Bottini N, Wicker LS, Sherman LA.

J Immunol. 2012 Jun 1;188(11):5267-75. doi: 10.4049/jimmunol.1200150. Epub 2012 Apr 25.


Protein tyrosine phosphatases in lymphocyte activation and autoimmunity.

Rhee I, Veillette A.

Nat Immunol. 2012 Apr 18;13(5):439-47. doi: 10.1038/ni.2246. Review.


LYP inhibits T-cell activation when dissociated from CSK.

Vang T, Liu WH, Delacroix L, Wu S, Vasile S, Dahl R, Yang L, Musumeci L, Francis D, Landskron J, Tasken K, Tremblay ML, Lie BA, Page R, Mustelin T, Rahmouni S, Rickert RC, Tautz L.

Nat Chem Biol. 2012 Mar 18;8(5):437-46. doi: 10.1038/nchembio.916.


Altered B cell homeostasis is associated with type I diabetes and carriers of the PTPN22 allelic variant.

Habib T, Funk A, Rieck M, Brahmandam A, Dai X, Panigrahi AK, Luning Prak ET, Meyer-Bahlburg A, Sanda S, Greenbaum C, Rawlings DJ, Buckner JH.

J Immunol. 2012 Jan 1;188(1):487-96. doi: 10.4049/jimmunol.1102176. Epub 2011 Nov 21.


WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity.

Becker-Herman S, Meyer-Bahlburg A, Schwartz MA, Jackson SW, Hudkins KL, Liu C, Sather BD, Khim S, Liggitt D, Song W, Silverman GJ, Alpers CE, Rawlings DJ.

J Exp Med. 2011 Sep 26;208(10):2033-42. doi: 10.1084/jem.20110200. Epub 2011 Aug 29.


Lyp breakdown and autoimmunity.

Behrens TW.

Nat Genet. 2011 Aug 29;43(9):821-2. doi: 10.1038/ng.914. No abstract available.


The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness.

Zhang J, Zahir N, Jiang Q, Miliotis H, Heyraud S, Meng X, Dong B, Xie G, Qiu F, Hao Z, McCulloch CA, Keystone EC, Peterson AC, Siminovitch KA.

Nat Genet. 2011 Aug 14;43(9):902-7. doi: 10.1038/ng.904.


The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans.

Menard L, Saadoun D, Isnardi I, Ng YS, Meyers G, Massad C, Price C, Abraham C, Motaghedi R, Buckner JH, Gregersen PK, Meffre E.

J Clin Invest. 2011 Sep;121(9):3635-44. doi: 10.1172/JCI45790. Epub 2011 Aug 1.


Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate.

Yu X, Chen M, Zhang S, Yu ZH, Sun JP, Wang L, Liu S, Imasaki T, Takagi Y, Zhang ZY.

J Biol Chem. 2011 Sep 2;286(35):30526-34. doi: 10.1074/jbc.M111.254722. Epub 2011 Jun 30.


Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c⁺ B-cell population is important for the development of autoimmunity.

Rubtsov AV, Rubtsova K, Fischer A, Meehan RT, Gillis JZ, Kappler JW, Marrack P.

Blood. 2011 Aug 4;118(5):1305-15. doi: 10.1182/blood-2011-01-331462. Epub 2011 May 4.


CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development.

Zikherman J, Jenne C, Watson S, Doan K, Raschke W, Goodnow CC, Weiss A.

Immunity. 2010 Mar 26;32(3):342-54. doi: 10.1016/j.immuni.2010.03.006.


Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance.

Fu G, Chen Y, Yu M, Podd A, Schuman J, He Y, Di L, Yassai M, Haribhai D, North PE, Gorski J, Williams CB, Wang D, Wen R.

J Exp Med. 2010 Feb 15;207(2):309-18. doi: 10.1084/jem.20090880. Epub 2010 Feb 1.


Dysregulation of germinal centres in autoimmune disease.

Vinuesa CG, Sanz I, Cook MC.

Nat Rev Immunol. 2009 Dec;9(12):845-57. doi: 10.1038/nri2637. Review.


Molecular orchestration of differentiation and function of regulatory T cells.

Lu LF, Rudensky A.

Genes Dev. 2009 Jun 1;23(11):1270-82. doi: 10.1101/gad.1791009.


PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background.

Zikherman J, Hermiston M, Steiner D, Hasegawa K, Chan A, Weiss A.

J Immunol. 2009 Apr 1;182(7):4093-106. doi: 10.4049/jimmunol.0803317.


Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling.

Arechiga AF, Habib T, He Y, Zhang X, Zhang ZY, Funk A, Buckner JH.

J Immunol. 2009 Mar 15;182(6):3343-7. doi: 10.4049/jimmunol.0713370.


Transitional B cells exhibit a B cell receptor-specific nuclear defect in gene transcription.

Andrews SF, Rawlings DJ.

J Immunol. 2009 Mar 1;182(5):2868-78. doi: 10.4049/jimmunol.0802368.


Protein tyrosine phosphatases in autoimmunity.

Vang T, Miletic AV, Arimura Y, Tautz L, Rickert RC, Mustelin T.

Annu Rev Immunol. 2008;26:29-55. doi: 10.1146/annurev.immunol.26.021607.090418. Review.


Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation.

Meyer-Bahlburg A, Andrews SF, Yu KO, Porcelli SA, Rawlings DJ.

J Exp Med. 2008 Jan 21;205(1):155-68. doi: 10.1084/jem.20071088. Epub 2008 Jan 7.


PTPN22: its role in SLE and autoimmunity.

Chung SA, Criswell LA.

Autoimmunity. 2007 Dec;40(8):582-90. Review.

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