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References for PMC Articles for PubMed (Select 23580869)


Pharmacokinetics of ethionamide in children.

Thee S, Seifart HI, Rosenkranz B, Hesseling AC, Magdorf K, Donald PR, Schaaf HS.

Antimicrob Agents Chemother. 2011 Oct;55(10):4594-600. doi: 10.1128/AAC.00379-11. Epub 2011 Jul 25.


Wild-type distributions of seven oral second-line drugs against Mycobacterium tuberculosis.

Schön T, Juréen P, Chryssanthou E, Giske CG, Sturegård E, Kahlmeter G, Hoffner S, Angeby KA.

Int J Tuberc Lung Dis. 2011 Apr;15(4):502-9. doi: 10.5588/ijtld.10.0238.


Bioactivation of antituberculosis thioamide and thiourea prodrugs by bacterial and mammalian flavin monooxygenases.

Nishida CR, Ortiz de Montellano PR.

Chem Biol Interact. 2011 Jun 30;192(1-2):21-5. doi: 10.1016/j.cbi.2010.09.015. Epub 2010 Sep 21.


Characterization of sulfoxygenation and structural implications of human flavin-containing monooxygenase isoform 2 (FMO2.1) variants S195L and N413K.

Krueger SK, Henderson MC, Siddens LK, VanDyke JE, Benninghoff AD, Karplus PA, Furnes B, Schlenk D, Williams DE.

Drug Metab Dispos. 2009 Aug;37(8):1785-91. doi: 10.1124/dmd.109.027201. Epub 2009 May 6.


Deletion of the mouse Fmo1 gene results in enhanced pharmacological behavioural responses to imipramine.

Hernandez D, Janmohamed A, Chandan P, Omar BA, Phillips IR, Shephard EA.

Pharmacogenet Genomics. 2009 Apr;19(4):289-99. doi: 10.1097/FPC.0b013e328328d507.


Human flavin-containing monooxygenase 2.1 catalyzes oxygenation of the antitubercular drugs thiacetazone and ethionamide.

Francois AA, Nishida CR, de Montellano PR, Phillips IR, Shephard EA.

Drug Metab Dispos. 2009 Jan;37(1):178-86. doi: 10.1124/dmd.108.024158. Epub 2008 Oct 23.


Metabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomes.

Henderson MC, Siddens LK, Morré JT, Krueger SK, Williams DE.

Toxicol Appl Pharmacol. 2008 Dec 15;233(3):420-7. doi: 10.1016/j.taap.2008.09.017. Epub 2008 Oct 1.


The potentially deleterious functional variant flavin-containing monooxygenase 2*1 is at high frequency throughout sub-Saharan Africa.

Veeramah KR, Thomas MG, Weale ME, Zeitlyn D, Tarekegn A, Bekele E, Mendell NR, Shephard EA, Bradman N, Phillips IR.

Pharmacogenet Genomics. 2008 Oct;18(10):877-86. doi: 10.1097/FPC.0b013e3283097311.


Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis.

Vilchèze C, Av-Gay Y, Attarian R, Liu Z, Hazbón MH, Colangeli R, Chen B, Liu W, Alland D, Sacchettini JC, Jacobs WR Jr.

Mol Microbiol. 2008 Sep;69(5):1316-29. doi: 10.1111/j.1365-2958.2008.06365.x. Epub 2008 Jul 21.


Flavin-containing monooxygenases: mutations, disease and drug response.

Phillips IR, Shephard EA.

Trends Pharmacol Sci. 2008 Jun;29(6):294-301. doi: 10.1016/ Epub 2008 Apr 16. Review.


Characterization of mouse flavin-containing monooxygenase transcript levels in lung and liver, and activity of expressed isoforms.

Siddens LK, Henderson MC, Vandyke JE, Williams DE, Krueger SK.

Biochem Pharmacol. 2008 Jan 15;75(2):570-9. Epub 2007 Sep 8.


EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targets.

Dover LG, Alahari A, Gratraud P, Gomes JM, Bhowruth V, Reynolds RC, Besra GS, Kremer L.

Antimicrob Agents Chemother. 2007 Mar;51(3):1055-63. Epub 2007 Jan 12.


Deletion of genes from the mouse genome using Cre/loxP technology.

Hernandez D, Chandan P, Janmohamed A, Phillips lR, Shephard EA.

Methods Mol Biol. 2006;320:307-19.


Differences in FMO2*1 allelic frequency between Hispanics of Puerto Rican and Mexican descent.

Krueger SK, Siddens LK, Martin SR, Yu Z, Pereira CB, Cabacungan ET, Hines RN, Ardlie KG, Raucy JL, Williams DE.

Drug Metab Dispos. 2004 Dec;32(12):1337-40. Epub 2004 Sep 8.


Human flavin-containing monooxygenase form 2 S-oxygenation: sulfenic acid formation from thioureas and oxidation of glutathione.

Henderson MC, Krueger SK, Stevens JF, Williams DE.

Chem Res Toxicol. 2004 May;17(5):633-40.


Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans.

Furnes B, Feng J, Sommer SS, Schlenk D.

Drug Metab Dispos. 2003 Feb;31(2):187-93.


The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase.

Vannelli TA, Dykman A, Ortiz de Montellano PR.

J Biol Chem. 2002 Apr 12;277(15):12824-9. Epub 2002 Jan 31.

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