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Results: 1 to 20 of 63

1.

Contribution of Kunitz protease inhibitor and transmembrane domains to amyloid precursor protein homodimerization.

Ben Khalifa N, Tyteca D, Courtoy PJ, Renauld JC, Constantinescu SN, Octave JN, Kienlen-Campard P.

Neurodegener Dis. 2012;10(1-4):92-5. doi: 10.1159/000335225. Epub 2012 Feb 10.

PMID:
22343802
[PubMed - indexed for MEDLINE]
2.

Functions of the APP gene family in the nervous system: insights from mouse models.

Aydin D, Weyer SW, Müller UC.

Exp Brain Res. 2012 Apr;217(3-4):423-34. doi: 10.1007/s00221-011-2861-2. Epub 2011 Sep 20. Review.

PMID:
21931985
[PubMed - indexed for MEDLINE]
3.

N-cadherin enhances APP dimerization at the extracellular domain and modulates Aβ production.

Asada-Utsugi M, Uemura K, Noda Y, Kuzuya A, Maesako M, Ando K, Kubota M, Watanabe K, Takahashi M, Kihara T, Shimohama S, Takahashi R, Berezovska O, Kinoshita A.

J Neurochem. 2011 Oct;119(2):354-63. doi: 10.1111/j.1471-4159.2011.07364.x. Epub 2011 Sep 20.

PMID:
21699541
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease.

Duce JA, Tsatsanis A, Cater MA, James SA, Robb E, Wikhe K, Leong SL, Perez K, Johanssen T, Greenough MA, Cho HH, Galatis D, Moir RD, Masters CL, McLean C, Tanzi RE, Cappai R, Barnham KJ, Ciccotosto GD, Rogers JT, Bush AI.

Cell. 2010 Sep 17;142(6):857-67. doi: 10.1016/j.cell.2010.08.014.

PMID:
20817278
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization.

Richter L, Munter LM, Ness J, Hildebrand PW, Dasari M, Unterreitmeier S, Bulic B, Beyermann M, Gust R, Reif B, Weggen S, Langosch D, Multhaup G.

Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14597-602. doi: 10.1073/pnas.1003026107. Epub 2010 Aug 2.

PMID:
20679249
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Aberrant amyloid precursor protein (APP) processing in hereditary forms of Alzheimer disease caused by APP familial Alzheimer disease mutations can be rescued by mutations in the APP GxxxG motif.

Munter LM, Botev A, Richter L, Hildebrand PW, Althoff V, Weise C, Kaden D, Multhaup G.

J Biol Chem. 2010 Jul 9;285(28):21636-43. doi: 10.1074/jbc.M109.088005. Epub 2010 May 7.

PMID:
20452985
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein.

Dahms SO, Hoefgen S, Roeser D, Schlott B, Gührs KH, Than ME.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5381-6. doi: 10.1073/pnas.0911326107. Epub 2010 Mar 8. Erratum in: Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2629.

PMID:
20212142
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Cell-type dependent modulation of Notch signaling by the amyloid precursor protein.

Oh SY, Chen CD, Abraham CR.

J Neurochem. 2010 Apr;113(1):262-74. doi: 10.1111/j.1471-4159.2010.06603.x. Epub 2010 Jan 20.

PMID:
20089128
[PubMed - indexed for MEDLINE]
9.

Induced dimerization of the amyloid precursor protein leads to decreased amyloid-beta protein production.

Eggert S, Midthune B, Cottrell B, Koo EH.

J Biol Chem. 2009 Oct 16;284(42):28943-52. doi: 10.1074/jbc.M109.038646. Epub 2009 Jul 13.

PMID:
19596858
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Neuroprotective secreted amyloid precursor protein acts by disrupting amyloid precursor protein dimers.

Gralle M, Botelho MG, Wouters FS.

J Biol Chem. 2009 May 29;284(22):15016-25. doi: 10.1074/jbc.M808755200. Epub 2009 Mar 31.

PMID:
19336403
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Transmembrane structures of amyloid precursor protein dimer predicted by replica-exchange molecular dynamics simulations.

Miyashita N, Straub JE, Thirumalai D, Sugita Y.

J Am Chem Soc. 2009 Mar 18;131(10):3438-9. doi: 10.1021/ja809227c.

PMID:
19275251
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

A helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis.

Sato T, Tang TC, Reubins G, Fei JZ, Fujimoto T, Kienlen-Campard P, Constantinescu SN, Octave JN, Aimoto S, Smith SO.

Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1421-6. doi: 10.1073/pnas.0812261106. Epub 2009 Jan 21.

PMID:
19164538
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2.

Kaden D, Voigt P, Munter LM, Bobowski KD, Schaefer M, Multhaup G.

J Cell Sci. 2009 Feb 1;122(Pt 3):368-77. doi: 10.1242/jcs.034058. Epub 2009 Jan 6.

PMID:
19126676
[PubMed - indexed for MEDLINE]
Free Article
14.

Substrate-targeting gamma-secretase modulators.

Kukar TL, Ladd TB, Bann MA, Fraering PC, Narlawar R, Maharvi GM, Healy B, Chapman R, Welzel AT, Price RW, Moore B, Rangachari V, Cusack B, Eriksen J, Jansen-West K, Verbeeck C, Yager D, Eckman C, Ye W, Sagi S, Cottrell BA, Torpey J, Rosenberry TL, Fauq A, Wolfe MS, Schmidt B, Walsh DM, Koo EH, Golde TE.

Nature. 2008 Jun 12;453(7197):925-9. doi: 10.1038/nature07055.

PMID:
18548070
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants.

Gorman PM, Kim S, Guo M, Melnyk RA, McLaurin J, Fraser PE, Bowie JU, Chakrabartty A.

BMC Neurosci. 2008 Jan 30;9:17. doi: 10.1186/1471-2202-9-17.

PMID:
18234110
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs.

Kienlen-Campard P, Tasiaux B, Van Hees J, Li M, Huysseune S, Sato T, Fei JZ, Aimoto S, Courtoy PJ, Smith SO, Constantinescu SN, Octave JN.

J Biol Chem. 2008 Mar 21;283(12):7733-44. doi: 10.1074/jbc.M707142200. Epub 2008 Jan 16. Erratum in: J Biol Chem. 2008 May 2;283(18):12680.

PMID:
18201969
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Homophilic interactions of the amyloid precursor protein (APP) ectodomain are regulated by the loop region and affect beta-secretase cleavage of APP.

Kaden D, Munter LM, Joshi M, Treiber C, Weise C, Bethge T, Voigt P, Schaefer M, Beyermann M, Reif B, Multhaup G.

J Biol Chem. 2008 Mar 14;283(11):7271-9. doi: 10.1074/jbc.M708046200. Epub 2008 Jan 8.

PMID:
18182389
[PubMed - indexed for MEDLINE]
Free Article
18.

A critical function for beta-amyloid precursor protein in neuronal migration revealed by in utero RNA interference.

Young-Pearse TL, Bai J, Chang R, Zheng JB, LoTurco JJ, Selkoe DJ.

J Neurosci. 2007 Dec 26;27(52):14459-69.

PMID:
18160654
[PubMed - indexed for MEDLINE]
Free Article
19.

Active gamma-secretase complexes contain only one of each component.

Sato T, Diehl TS, Narayanan S, Funamoto S, Ihara Y, De Strooper B, Steiner H, Haass C, Wolfe MS.

J Biol Chem. 2007 Nov 23;282(47):33985-93. Epub 2007 Oct 2.

PMID:
17911105
[PubMed - indexed for MEDLINE]
Free Article

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