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Items: 1 to 20 of 92


Differential effects of blockade of ERG channels on gamma oscillations and excitability in rat hippocampal slices.

Fano S, Çalışkan G, Heinemann U.

Eur J Neurosci. 2012 Dec;36(12):3628-35. doi: 10.1111/ejn.12015. Epub 2012 Oct 10.


Arsenic trioxide induces the apoptosis of human breast cancer MCF-7 cells through activation of caspase-3 and inhibition of HERG channels.

Wang Y, Zhang Y, Yang L, Cai B, Li J, Zhou Y, Yin L, Yang L, Yang BF, Lu YJ.

Exp Ther Med. 2011 May;2(3):481-486. Epub 2011 Mar 8.


Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.

Huang X, Dubuc AM, Hashizume R, Berg J, He Y, Wang J, Chiang C, Cooper MK, Northcott PA, Taylor MD, Barnes MJ, Tihan T, Chen J, Hackett CS, Weiss WA, James CD, Rowitch DH, Shuman MA, Jan YN, Jan LY.

Genes Dev. 2012 Aug 15;26(16):1780-96. doi: 10.1101/gad.193789.112. Epub 2012 Aug 1.


Functional characterization of ether-à-go-go-related gene potassium channels in midbrain dopamine neurons - implications for a role in depolarization block.

Ji H, Tucker KR, Putzier I, Huertas MA, Horn JP, Canavier CC, Levitan ES, Shepard PD.

Eur J Neurosci. 2012 Oct;36(7):2906-16. doi: 10.1111/j.1460-9568.2012.08190.x. Epub 2012 Jul 11.


Genetic variation in KCNH2 associated with expression in the brain of a unique hERG isoform modulates treatment response in patients with schizophrenia.

Apud JA, Zhang F, Decot H, Bigos KL, Weinberger DR.

Am J Psychiatry. 2012 Jul;169(7):725-34. doi: 10.1176/appi.ajp.2012.11081214.


Human ether-a-go-go-related gene K+ channels regulate shedding of leukemia cell-derived microvesicles.

Zheng F, Li J, Du W, Wang N, Li H, Huang S.

Leuk Lymphoma. 2012 Aug;53(8):1592-8. doi: 10.3109/10428194.2012.661855. Epub 2012 Mar 13.


Imatinib has the potential to exert its antileukemia effects by down-regulating hERG1 K+ channels in chronic myelogenous leukemia.

Zheng F, Li H, Liang K, Du Y, Guo D, Huang S.

Med Oncol. 2012 Sep;29(3):2127-35. doi: 10.1007/s12032-011-0102-y. Epub 2011 Dec 10.


Inhibition of HERG1 K+ channel protein expression decreases cell proliferation of human small cell lung cancer cells.

Glassmeier G, Hempel K, Wulfsen I, Bauer CK, Schumacher U, Schwarz JR.

Pflugers Arch. 2012 Feb;463(2):365-76. doi: 10.1007/s00424-011-1045-z. Epub 2011 Nov 11.


Novel roles for hERG K(+) channels in cell proliferation and apoptosis.

Jehle J, Schweizer PA, Katus HA, Thomas D.

Cell Death Dis. 2011 Aug 18;2:e193. doi: 10.1038/cddis.2011.77. Review.


Mechanisms of atrial-selective block of Na⁺ channels by ranolazine: I. Experimental analysis of the use-dependent block.

Zygmunt AC, Nesterenko VV, Rajamani S, Hu D, Barajas-Martinez H, Belardinelli L, Antzelevitch C.

Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1606-14. doi: 10.1152/ajpheart.00242.2011. Epub 2011 Aug 5.


Functional integrative levels in the human interactome recapitulate organ organization.

Souiai O, Becker E, Prieto C, Benkahla A, De las Rivas J, Brun C.

PLoS One. 2011;6(7):e22051. doi: 10.1371/journal.pone.0022051. Epub 2011 Jul 20.


Altered gene expression by low-dose arsenic exposure in humans and cultured cardiomyocytes: assessment by real-time PCR arrays.

Mo J, Xia Y, Wade TJ, DeMarini DM, Davidson M, Mumford J.

Int J Environ Res Public Health. 2011 Jun;8(6):2090-108. doi: 10.3390/ijerph8062090. Epub 2011 Jun 8.


Acceleration of sperm transit time and reduction of sperm reserves in the epididymis of rats exposed to sibutramine.

Bellentani FF, Fernandes GS, Perobelli JE, Pacini ES, Kiguti LR, Pupo AS, Kempinas WD.

J Androl. 2011 Nov-Dec;32(6):718-24. doi: 10.2164/jandrol.111.013466. Epub 2011 Jul 15.


Role of hERG1 K(+) channels in leukemia cells as a positive regulator in SDF-1a-induced proliferation.

Zheng F, Li H, Du W, Huang S.

Hematology. 2011 May;16(3):177-84. doi: 10.1179/102453311X12940641878000.


Progesterone impairs human ether-a-go-go-related gene (HERG) trafficking by disruption of intracellular cholesterol homeostasis.

Wu ZY, Yu DJ, Soong TW, Dawe GS, Bian JS.

J Biol Chem. 2011 Jun 24;286(25):22186-94. doi: 10.1074/jbc.M110.198853. Epub 2011 Apr 27.


The role of Eag and HERG channels in cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line.

Asher V, Warren A, Shaw R, Sowter H, Bali A, Khan R.

Cancer Cell Int. 2011 Mar 10;11:6. doi: 10.1186/1475-2867-11-6.


The role of inflammation in epilepsy.

Vezzani A, French J, Bartfai T, Baram TZ.

Nat Rev Neurol. 2011 Jan;7(1):31-40. doi: 10.1038/nrneurol.2010.178. Epub 2010 Dec 7. Review.


Chemotherapy resistance in acute lymphoblastic leukemia requires hERG1 channels and is overcome by hERG1 blockers.

Pillozzi S, Masselli M, De Lorenzo E, Accordi B, Cilia E, Crociani O, Amedei A, Veltroni M, D'Amico M, Basso G, Becchetti A, Campana D, Arcangeli A.

Blood. 2011 Jan 20;117(3):902-14. doi: 10.1182/blood-2010-01-262691. Epub 2010 Nov 3.


Systems pharmacology of arrhythmias.

Berger SI, Ma'ayan A, Iyengar R.

Sci Signal. 2010 Apr 20;3(118):ra30. doi: 10.1126/scisignal.2000723. Erratum in: Sci Signal. 2010;3(121):er5.


Regulation of the voltage-insensitive step of HERG activation by extracellular pH.

Zhou Q, Bett GC.

Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H1710-8. doi: 10.1152/ajpheart.01246.2009. Epub 2010 Apr 2.

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