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A peptidic unconjugated GRP78/BiP ligand modulates the unfolded protein response and induces prostate cancer cell death.

Maddalo D, Neeb A, Jehle K, Schmitz K, Muhle-Goll C, Shatkina L, Walther TV, Bruchmann A, Gopal SM, Wenzel W, Ulrich AS, Cato AC.

PLoS One. 2012;7(10):e45690. doi: 10.1371/journal.pone.0045690. Epub 2012 Oct 1.


A murine monoclonal antibody directed against the carboxyl-terminal domain of GRP78 suppresses melanoma growth in mice.

de Ridder GG, Ray R, Pizzo SV.

Melanoma Res. 2012 Jun;22(3):225-35. doi: 10.1097/CMR.0b013e32835312fd.


Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signalling network.

Uckun FM, Qazi S, Ozer Z, Garner AL, Pitt J, Ma H, Janda KD.

Br J Haematol. 2011 Jun;153(6):741-52. doi: 10.1111/j.1365-2141.2011.08671.x. Epub 2011 Apr 25.


GRP78 up-regulation is associated with androgen receptor status, Hsp70-Hsp90 client proteins and castrate-resistant prostate cancer.

Tan SS, Ahmad I, Bennett HL, Singh L, Nixon C, Seywright M, Barnetson RJ, Edwards J, Leung HY.

J Pathol. 2011 Jan;223(1):81-7. doi: 10.1002/path.2795. Epub 2010 Oct 28.


Targeted nanoparticles that deliver a sustained, specific release of Paclitaxel to irradiated tumors.

Passarella RJ, Spratt DE, van der Ende AE, Phillips JG, Wu H, Sathiyakumar V, Zhou L, Hallahan DE, Harth E, Diaz R.

Cancer Res. 2010 Jun 1;70(11):4550-9. doi: 10.1158/0008-5472.CAN-10-0339. Epub 2010 May 18.


GRP78 as potential predictor for breast cancer response to adjuvant taxane therapy.

Lee E, Nichols P, Groshen S, Spicer D, Lee AS.

Int J Cancer. 2011 Feb 1;128(3):726-31. doi: 10.1002/ijc.25370.


Cancer antineovascular therapy with liposome drug delivery systems targeted to BiP/GRP78.

Katanasaka Y, Ishii T, Asai T, Naitou H, Maeda N, Koizumi F, Miyagawa S, Ohashi N, Oku N.

Int J Cancer. 2010 Dec 1;127(11):2685-98. doi: 10.1002/ijc.25276.


Activation and clinical significance of the unfolded protein response in breast cancer.

Scriven P, Coulson S, Haines R, Balasubramanian S, Cross S, Wyld L.

Br J Cancer. 2009 Nov 17;101(10):1692-8. doi: 10.1038/sj.bjc.6605365. Epub 2009 Oct 27.


Regulation of PERK signaling and leukemic cell survival by a novel cytosolic isoform of the UPR regulator GRP78/BiP.

Ni M, Zhou H, Wey S, Baumeister P, Lee AS.

PLoS One. 2009 Aug 31;4(8):e6868. doi: 10.1371/journal.pone.0006868.


Role of the unfolded protein response regulator GRP78/BiP in development, cancer, and neurological disorders.

Wang M, Wey S, Zhang Y, Ye R, Lee AS.

Antioxid Redox Signal. 2009 Sep;11(9):2307-16. doi: 10.1089/ARS.2009.2485.


Preventing the unfolded protein response via aberrant activation of 4E-binding protein 1 by versipelostatin.

Matsuo J, Tsukumo Y, Sakurai J, Tsukahara S, Park HR, Shin-ya K, Watanabe T, Tsuruo T, Tomida A.

Cancer Sci. 2009 Feb;100(2):327-33. doi: 10.1111/j.1349-7006.2008.01036.x.


Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium.

Fu Y, Wey S, Wang M, Ye R, Liao CP, Roy-Burman P, Lee AS.

Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19444-9. doi: 10.1073/pnas.0807691105. Epub 2008 Nov 25.


Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells.

Virrey JJ, Dong D, Stiles C, Patterson JB, Pen L, Ni M, Schönthal AH, Chen TC, Hofman FM, Lee AS.

Mol Cancer Res. 2008 Aug;6(8):1268-75. doi: 10.1158/1541-7786.MCR-08-0060.


A new tumor-specific variant of GRP78 as target for antibody-based therapy.

Rauschert N, Brändlein S, Holzinger E, Hensel F, Müller-Hermelink HK, Vollmers HP.

Lab Invest. 2008 Apr;88(4):375-86. doi: 10.1038/labinvest.2008.2. Epub 2008 Feb 11.


A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy.

Yoneda Y, Steiniger SC, Capková K, Mee JM, Liu Y, Kaufmann GF, Janda KD.

Bioorg Med Chem Lett. 2008 Mar 1;18(5):1632-6. doi: 10.1016/j.bmcl.2008.01.060. Epub 2008 Jan 19.


The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas.

Pyrko P, Schönthal AH, Hofman FM, Chen TC, Lee AS.

Cancer Res. 2007 Oct 15;67(20):9809-16.


Glucose-regulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival.

Daneshmand S, Quek ML, Lin E, Lee C, Cote RJ, Hawes D, Cai J, Groshen S, Lieskovsky G, Skinner DG, Lee AS, Pinski J.

Hum Pathol. 2007 Oct;38(10):1547-52. Epub 2007 Jul 19.


ER stress triggers apoptosis by activating BH3-only protein Bim.

Puthalakath H, O'Reilly LA, Gunn P, Lee L, Kelly PN, Huntington ND, Hughes PD, Michalak EM, McKimm-Breschkin J, Motoyama N, Gotoh T, Akira S, Bouillet P, Strasser A.

Cell. 2007 Jun 29;129(7):1337-49.


The human IgM antibody SAM-6 induces tumor-specific apoptosis with oxidized low-density lipoprotein.

Brändlein S, Rauschert N, Rasche L, Dreykluft A, Hensel F, Conzelmann E, Müller-Hermelink HK, Vollmers HP.

Mol Cancer Ther. 2007 Jan;6(1):326-33.

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