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Results: 1 to 20 of 38

1.

Contraction-induced interleukin-6 gene transcription in skeletal muscle is regulated by c-Jun terminal kinase/activator protein-1.

Whitham M, Chan MH, Pal M, Matthews VB, Prelovsek O, Lunke S, El-Osta A, Broenneke H, Alber J, Brüning JC, Wunderlich FT, Lancaster GI, Febbraio MA.

J Biol Chem. 2012 Mar 30;287(14):10771-9. doi: 10.1074/jbc.M111.310581. Epub 2012 Feb 18.

PMID:
22351769
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism.

Belgardt BF, Mauer J, Wunderlich FT, Ernst MB, Pal M, Spohn G, Brönneke HS, Brodesser S, Hampel B, Schauss AC, Brüning JC.

Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):6028-33. doi: 10.1073/pnas.1001796107. Epub 2010 Mar 15.

PMID:
20231445
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1.

Sabio G, Cavanagh-Kyros J, Barrett T, Jung DY, Ko HJ, Ong H, Morel C, Mora A, Reilly J, Kim JK, Davis RJ.

Genes Dev. 2010 Feb 1;24(3):256-64. doi: 10.1101/gad.1878510. Epub 2010 Jan 15.

PMID:
20080940
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Prevention of steatosis by hepatic JNK1.

Sabio G, Cavanagh-Kyros J, Ko HJ, Jung DY, Gray S, Jun JY, Barrett T, Mora A, Kim JK, Davis RJ.

Cell Metab. 2009 Dec;10(6):491-8. doi: 10.1016/j.cmet.2009.09.007.

PMID:
19945406
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance.

Sabio G, Kennedy NJ, Cavanagh-Kyros J, Jung DY, Ko HJ, Ong H, Barrett T, Kim JK, Davis RJ.

Mol Cell Biol. 2010 Jan;30(1):106-15. doi: 10.1128/MCB.01162-09. Epub .

PMID:
19841069
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Inactivation of the Fto gene protects from obesity.

Fischer J, Koch L, Emmerling C, Vierkotten J, Peters T, Brüning JC, Rüther U.

Nature. 2009 Apr 16;458(7240):894-8. doi: 10.1038/nature07848. Epub 2009 Feb 22.

PMID:
19234441
[PubMed - indexed for MEDLINE]
7.

A stress signaling pathway in adipose tissue regulates hepatic insulin resistance.

Sabio G, Das M, Mora A, Zhang Z, Jun JY, Ko HJ, Barrett T, Kim JK, Davis RJ.

Science. 2008 Dec 5;322(5907):1539-43. doi: 10.1126/science.1160794.

PMID:
19056984
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity.

Vallerie SN, Furuhashi M, Fucho R, Hotamisligil GS.

PLoS One. 2008 Sep 5;3(9):e3151. doi: 10.1371/journal.pone.0003151. Erratum in: PLoS ONE. 2009;4(1). doi: 10.1371/annotation/1074cd39-708b-45ef-943a-e9d1c5bbdedd.

PMID:
18773087
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance.

Chibalin AV, Leng Y, Vieira E, Krook A, Björnholm M, Long YC, Kotova O, Zhong Z, Sakane F, Steiler T, Nylén C, Wang J, Laakso M, Topham MK, Gilbert M, Wallberg-Henriksson H, Zierath JR.

Cell. 2008 Feb 8;132(3):375-86. doi: 10.1016/j.cell.2007.12.035.

PMID:
18267070
[PubMed - indexed for MEDLINE]
Free Article
10.

Hepatic NF-kappa B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis.

Wunderlich FT, Luedde T, Singer S, Schmidt-Supprian M, Baumgartl J, Schirmacher P, Pasparakis M, Brüning JC.

Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1297-302. doi: 10.1073/pnas.0707849104. Epub 2008 Jan 23.

PMID:
18216263
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity.

Solinas G, Vilcu C, Neels JG, Bandyopadhyay GK, Luo JL, Naugler W, Grivennikov S, Wynshaw-Boris A, Scadeng M, Olefsky JM, Karin M.

Cell Metab. 2007 Nov;6(5):386-97.

PMID:
17983584
[PubMed - indexed for MEDLINE]
Free Article
12.

Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes.

Farese RV, Sajan MP, Yang H, Li P, Mastorides S, Gower WR Jr, Nimal S, Choi CS, Kim S, Shulman GI, Kahn CR, Braun U, Leitges M.

J Clin Invest. 2007 Aug;117(8):2289-301. Erratum in: J Clin Invest. 2007 Oct;117(10):3141.

PMID:
17641777
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production.

Könner AC, Janoschek R, Plum L, Jordan SD, Rother E, Ma X, Xu C, Enriori P, Hampel B, Barsh GS, Kahn CR, Cowley MA, Ashcroft FM, Brüning JC.

Cell Metab. 2007 Jun;5(6):438-49.

PMID:
17550779
[PubMed - indexed for MEDLINE]
Free Article
14.

Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates.

Solinas G, Naugler W, Galimi F, Lee MS, Karin M.

Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16454-9. Epub 2006 Oct 18.

PMID:
17050683
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance.

Tuncman G, Hirosumi J, Solinas G, Chang L, Karin M, Hotamisligil GS.

Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10741-6. Epub 2006 Jul 3.

PMID:
16818881
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity.

Plum L, Ma X, Hampel B, Balthasar N, Coppari R, Münzberg H, Shanabrough M, Burdakov D, Rother E, Janoschek R, Alber J, Belgardt BF, Koch L, Seibler J, Schwenk F, Fekete C, Suzuki A, Mak TW, Krone W, Horvath TL, Ashcroft FM, Brüning JC.

J Clin Invest. 2006 Jul;116(7):1886-901. Epub 2006 Jun 22.

PMID:
16794735
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Role of hepatic STAT3 in brain-insulin action on hepatic glucose production.

Inoue H, Ogawa W, Asakawa A, Okamoto Y, Nishizawa A, Matsumoto M, Teshigawara K, Matsuki Y, Watanabe E, Hiramatsu R, Notohara K, Katayose K, Okamura H, Kahn CR, Noda T, Takeda K, Akira S, Inui A, Kasuga M.

Cell Metab. 2006 Apr;3(4):267-75.

PMID:
16581004
[PubMed - indexed for MEDLINE]
Free Article
18.

Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation.

Plomgaard P, Bouzakri K, Krogh-Madsen R, Mittendorfer B, Zierath JR, Pedersen BK.

Diabetes. 2005 Oct;54(10):2939-45.

PMID:
16186396
[PubMed - indexed for MEDLINE]
Free Article
19.

Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB.

Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, Shoelson SE.

Nat Med. 2005 Feb;11(2):183-90. Epub 2005 Jan 30.

PMID:
15685173
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

IKK-beta links inflammation to obesity-induced insulin resistance.

Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, Wynshaw-Boris A, Poli G, Olefsky J, Karin M.

Nat Med. 2005 Feb;11(2):191-8. Epub 2005 Jan 30.

PMID:
15685170
[PubMed - indexed for MEDLINE]

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