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Items: 1 to 20 of 30

1.

Deletion of the ageing gene p66(Shc) reduces early stroke size following ischaemia/reperfusion brain injury.

Spescha RD, Shi Y, Wegener S, Keller S, Weber B, Wyss MM, Lauinger N, Tabatabai G, Paneni F, Cosentino F, Hock C, Weller M, Nitsch RM, Lüscher TF, Camici GG.

Eur Heart J. 2013 Jan;34(2):96-103. doi: 10.1093/eurheartj/ehs331. Epub 2012 Sep 24.

2.

Gene silencing of the mitochondrial adaptor p66(Shc) suppresses vascular hyperglycemic memory in diabetes.

Paneni F, Mocharla P, Akhmedov A, Costantino S, Osto E, Volpe M, Lüscher TF, Cosentino F.

Circ Res. 2012 Jul 20;111(3):278-89. doi: 10.1161/CIRCRESAHA.112.266593. Epub 2012 Jun 12.

3.

Protein C anticoagulant and cytoprotective pathways.

Griffin JH, Zlokovic BV, Mosnier LO.

Int J Hematol. 2012 Apr;95(4):333-45. doi: 10.1007/s12185-012-1059-0. Epub 2012 Apr 5. Review.

4.

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling.

Ray PD, Huang BW, Tsuji Y.

Cell Signal. 2012 May;24(5):981-90. doi: 10.1016/j.cellsig.2012.01.008. Epub 2012 Jan 20. Review.

5.

Genetic inactivation of the p66 isoform of ShcA is neuroprotective in a murine model of multiple sclerosis.

Su KG, Savino C, Marracci G, Chaudhary P, Yu X, Morris B, Galipeau D, Giorgio M, Forte M, Bourdette D.

Eur J Neurosci. 2012 Feb;35(4):562-71. doi: 10.1111/j.1460-9568.2011.07972.x. Epub 2012 Jan 25.

6.

Exogenous activated protein C inhibits the progression of diabetic nephropathy.

Gil-Bernabe P, D'Alessandro-Gabazza CN, Toda M, Boveda Ruiz D, Miyake Y, Suzuki T, Onishi Y, Morser J, Gabazza EC, Takei Y, Yano Y.

J Thromb Haemost. 2012 Mar;10(3):337-46. doi: 10.1111/j.1538-7836.2012.04621.x.

7.

Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes.

Madhusudhan T, Wang H, Straub BK, Gröne E, Zhou Q, Shahzad K, Müller-Krebs S, Schwenger V, Gerlitz B, Grinnell BW, Griffin JH, Reiser J, Gröne HJ, Esmon CT, Nawroth PP, Isermann B.

Blood. 2012 Jan 19;119(3):874-83. doi: 10.1182/blood-2011-07-365973. Epub 2011 Nov 23.

8.

Unexpected role of anticoagulant protein C in controlling epithelial barrier integrity and intestinal inflammation.

Vetrano S, Ploplis VA, Sala E, Sandoval-Cooper M, Donahue DL, Correale C, Arena V, Spinelli A, Repici A, Malesci A, Castellino FJ, Danese S.

Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19830-5. doi: 10.1073/pnas.1107140108. Epub 2011 Nov 22.

9.

Bioenergetic characterization of mouse podocytes.

Abe Y, Sakairi T, Kajiyama H, Shrivastav S, Beeson C, Kopp JB.

Am J Physiol Cell Physiol. 2010 Aug;299(2):C464-76. doi: 10.1152/ajpcell.00563.2009. Epub 2010 May 5.

10.

P66Shc signals to age.

Trinei M, Berniakovich I, Beltrami E, Migliaccio E, Fassina A, Pelicci P, Giorgio M.

Aging (Albany NY). 2009 Jun 5;1(6):503-10. Review.

11.

Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells.

Zhong Z, Ilieva H, Hallagan L, Bell R, Singh I, Paquette N, Thiyagarajan M, Deane R, Fernandez JA, Lane S, Zlokovic AB, Liu T, Griffin JH, Chow N, Castellino FJ, Stojanovic K, Cleveland DW, Zlokovic BV.

J Clin Invest. 2009 Nov;119(11):3437-49. doi: 10.1172/JCI38476. Epub 2009 Oct 19.

12.

Transcriptional repression of Kruppel like factor-2 by the adaptor protein p66shc.

Kumar A, Hoffman TA, Dericco J, Naqvi A, Jain MK, Irani K.

FASEB J. 2009 Dec;23(12):4344-52. doi: 10.1096/fj.09-138743. Epub 2009 Aug 20.

13.

Inhibition of p66ShcA longevity gene rescues podocytes from HIV-1-induced oxidative stress and apoptosis.

Husain M, Meggs LG, Vashistha H, Simoes S, Griffiths KO, Kumar D, Mikulak J, Mathieson PW, Saleem MA, Del Valle L, Pina-Oviedo S, Wang JY, Seshan SV, Malhotra A, Reiss K, Singhal PC.

J Biol Chem. 2009 Jun 12;284(24):16648-58. doi: 10.1074/jbc.M109.008482. Epub 2009 Apr 21.

14.

Oxidative stress as a major culprit in kidney disease in diabetes.

Forbes JM, Coughlan MT, Cooper ME.

Diabetes. 2008 Jun;57(6):1446-54. doi: 10.2337/db08-0057. Review.

15.

Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis.

Isermann B, Vinnikov IA, Madhusudhan T, Herzog S, Kashif M, Blautzik J, Corat MA, Zeier M, Blessing E, Oh J, Gerlitz B, Berg DT, Grinnell BW, Chavakis T, Esmon CT, Weiler H, Bierhaus A, Nawroth PP.

Nat Med. 2007 Nov;13(11):1349-58. Epub 2007 Nov 4.

PMID:
17982464
16.

Ablation of the gene encoding p66Shc protects mice against AGE-induced glomerulopathy by preventing oxidant-dependent tissue injury and further AGE accumulation.

Menini S, Iacobini C, Ricci C, Oddi G, Pesce C, Pugliese F, Block K, Abboud HE, Giorgio M, Migliaccio E, Pelicci PG, Pugliese G.

Diabetologia. 2007 Sep;50(9):1997-2007. Epub 2007 Jul 5.

PMID:
17611735
17.

Apoptosis induced by oxidized lipids is associated with up-regulation of p66Shc in intestinal Caco-2 cells: protective effects of phenolic compounds.

Giovannini C, Scazzocchio B, Matarrese P, Varì R, D'Archivio M, Di Benedetto R, Casciani S, Dessì MR, Straface E, Malorni W, Masella R.

J Nutr Biochem. 2008 Feb;19(2):118-28. Epub 2007 Jun 27.

PMID:
17588737
18.

Genetic deletion of p66(Shc) adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress.

Camici GG, Schiavoni M, Francia P, Bachschmid M, Martin-Padura I, Hersberger M, Tanner FC, Pelicci P, Volpe M, Anversa P, Lüscher TF, Cosentino F.

Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5217-22. Epub 2007 Mar 14.

19.
20.

Deletion of p66Shc longevity gene protects against experimental diabetic glomerulopathy by preventing diabetes-induced oxidative stress.

Menini S, Amadio L, Oddi G, Ricci C, Pesce C, Pugliese F, Giorgio M, Migliaccio E, Pelicci P, Iacobini C, Pugliese G.

Diabetes. 2006 Jun;55(6):1642-50.

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