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Results: 1 to 20 of 38

References for PMC Articles for PubMed (Select 23226465)


Epithelial transforming growth factor β-activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species.

Omori E, Inagaki M, Mishina Y, Matsumoto K, Ninomiya-Tsuji J.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3365-70. doi: 10.1073/pnas.1116188109. Epub 2012 Feb 13.


TNF-α/Fas-RIP-1-induced cell death signaling separates murine hematopoietic stem cells/progenitors into 2 distinct populations.

Xiao Y, Li H, Zhang J, Volk A, Zhang S, Wei W, Zhang S, Breslin P, Zhang J.

Blood. 2011 Dec 1;118(23):6057-67. doi: 10.1182/blood-2011-06-359448. Epub 2011 Oct 11.


Metabolic regulation of hematopoietic stem cells in the hypoxic niche.

Suda T, Takubo K, Semenza GL.

Cell Stem Cell. 2011 Oct 4;9(4):298-310. doi: 10.1016/j.stem.2011.09.010. Review.


Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors.

Pronk CJ, Veiby OP, Bryder D, Jacobsen SE.

J Exp Med. 2011 Aug 1;208(8):1563-70. doi: 10.1084/jem.20110752. Epub 2011 Jul 18.


Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells.

Gan B, Hu J, Jiang S, Liu Y, Sahin E, Zhuang L, Fletcher-Sananikone E, Colla S, Wang YA, Chin L, Depinho RA.

Nature. 2010 Dec 2;468(7324):701-4. doi: 10.1038/nature09595.


The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.

Gurumurthy S, Xie SZ, Alagesan B, Kim J, Yusuf RZ, Saez B, Tzatsos A, Ozsolak F, Milos P, Ferrari F, Park PJ, Shirihai OS, Scadden DT, Bardeesy N.

Nature. 2010 Dec 2;468(7324):659-63. doi: 10.1038/nature09572. Erratum in: Nature. 2011 Aug 4;476(7358):114.


Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells.

Nakada D, Saunders TL, Morrison SJ.

Nature. 2010 Dec 2;468(7324):653-8. doi: 10.1038/nature09571.


TGF-beta-activated kinase 1 signaling maintains intestinal integrity by preventing accumulation of reactive oxygen species in the intestinal epithelium.

Kajino-Sakamoto R, Omori E, Nighot PK, Blikslager AT, Matsumoto K, Ninomiya-Tsuji J.

J Immunol. 2010 Oct 15;185(8):4729-37. doi: 10.4049/jimmunol.0903587. Epub 2010 Sep 20.


Autoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular process.

Scholz R, Sidler CL, Thali RF, Winssinger N, Cheung PC, Neumann D.

J Biol Chem. 2010 Aug 13;285(33):25753-66. doi: 10.1074/jbc.M109.093468. Epub 2010 Jun 10.


Bmi1 regulates mitochondrial function and the DNA damage response pathway.

Liu J, Cao L, Chen J, Song S, Lee IH, Quijano C, Liu H, Keyvanfar K, Chen H, Cao LY, Ahn BH, Kumar NG, Rovira II, Xu XL, van Lohuizen M, Motoyama N, Deng CX, Finkel T.

Nature. 2009 May 21;459(7245):387-92. doi: 10.1038/nature08040. Epub 2009 Apr 29.


Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic activation of CreERT2.

Higashi AY, Ikawa T, Muramatsu M, Economides AN, Niwa A, Okuda T, Murphy AJ, Rojas J, Heike T, Nakahata T, Kawamoto H, Kita T, Yanagita M.

J Immunol. 2009 May 1;182(9):5633-40. doi: 10.4049/jimmunol.0802413.


Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair.

Wilson A, Laurenti E, Oser G, van der Wath RC, Blanco-Bose W, Jaworski M, Offner S, Dunant CF, Eshkind L, Bockamp E, Lió P, Macdonald HR, Trumpp A.

Cell. 2008 Dec 12;135(6):1118-29. doi: 10.1016/j.cell.2008.10.048. Erratum in: Cell. 2009 Jul 10;138(1):209.


TAK1-binding protein 1, TAB1, mediates osmotic stress-induced TAK1 activation but is dispensable for TAK1-mediated cytokine signaling.

Inagaki M, Omori E, Kim JY, Komatsu Y, Scott G, Ray MK, Yamada G, Matsumoto K, Mishina Y, Ninomiya-Tsuji J.

J Biol Chem. 2008 Nov 28;283(48):33080-6. doi: 10.1074/jbc.M807574200. Epub 2008 Oct 1.


Generation of a conditional mutant allele for Tab1 in mouse.

Inagaki M, Komatsu Y, Scott G, Yamada G, Ray M, Ninomiya-Tsuji J, Mishina Y.

Genesis. 2008 Aug;46(8):431-9. doi: 10.1002/dvg.20418.


TAK1 regulates reactive oxygen species and cell death in keratinocytes, which is essential for skin integrity.

Omori E, Morioka S, Matsumoto K, Ninomiya-Tsuji J.

J Biol Chem. 2008 Sep 19;283(38):26161-8. doi: 10.1074/jbc.M804513200. Epub 2008 Jul 7.


Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis.

Kajino-Sakamoto R, Inagaki M, Lippert E, Akira S, Robine S, Matsumoto K, Jobin C, Ninomiya-Tsuji J.

J Immunol. 2008 Jul 15;181(2):1143-52.


TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice.

Tang M, Wei X, Guo Y, Breslin P, Zhang S, Zhang S, Wei W, Xia Z, Diaz M, Akira S, Zhang J.

J Exp Med. 2008 Jul 7;205(7):1611-9. doi: 10.1084/jem.20080297. Epub 2008 Jun 23.


Hematopoiesis: an evolving paradigm for stem cell biology.

Orkin SH, Zon LI.

Cell. 2008 Feb 22;132(4):631-44. doi: 10.1016/j.cell.2008.01.025.


Vagaries of conditional gene targeting.

Schmidt-Supprian M, Rajewsky K.

Nat Immunol. 2007 Jul;8(7):665-8. Review. No abstract available.


FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress.

Tothova Z, Kollipara R, Huntly BJ, Lee BH, Castrillon DH, Cullen DE, McDowell EP, Lazo-Kallanian S, Williams IR, Sears C, Armstrong SA, Passegué E, DePinho RA, Gilliland DG.

Cell. 2007 Jan 26;128(2):325-39.

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