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Results: 1 to 20 of 52

1.

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients.

Coppieters KT, Dotta F, Amirian N, Campbell PD, Kay TW, Atkinson MA, Roep BO, von Herrath MG.

J Exp Med. 2012 Jan 16;209(1):51-60. doi: 10.1084/jem.20111187. Epub 2012 Jan 2.

PMID:
22213807
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

HLA-A2-matched peripheral blood mononuclear cells from type 1 diabetic patients, but not nondiabetic donors, transfer insulitis to NOD-scid/γc(null)/HLA-A2 transgenic mice concurrent with the expansion of islet-specific CD8+ T cells.

Whitfield-Larry F, Young EF, Talmage G, Fudge E, Azam A, Patel S, Largay J, Byrd W, Buse J, Calikoglu AS, Shultz LD, Frelinger JA.

Diabetes. 2011 Jun;60(6):1726-33. doi: 10.2337/db10-1287. Epub 2011 Apr 26.

PMID:
21521873
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Prevention of "Humanized" diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach.

Niens M, Grier AE, Marron M, Kay TW, Greiner DL, Serreze DV.

Diabetes. 2011 Apr;60(4):1229-36. doi: 10.2337/db10-1523. Epub 2011 Feb 23.

PMID:
21346176
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Islet inflammation and CXCL10 in recent-onset type 1 diabetes.

Roep BO, Kleijwegt FS, van Halteren AG, Bonato V, Boggi U, Vendrame F, Marchetti P, Dotta F.

Clin Exp Immunol. 2010 Mar;159(3):338-43. doi: 10.1111/j.1365-2249.2009.04087.x. Epub 2010 Jan 5.

PMID:
20059481
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

CD8(+) T lymphocyte mobilization to virus-infected tissue requires CD4(+) T-cell help.

Nakanishi Y, Lu B, Gerard C, Iwasaki A.

Nature. 2009 Nov 26;462(7272):510-3. doi: 10.1038/nature08511. Epub 2009 Nov 8.

PMID:
19898495
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event.

Lennon GP, Bettini M, Burton AR, Vincent E, Arnold PY, Santamaria P, Vignali DA.

Immunity. 2009 Oct 16;31(4):643-53. doi: 10.1016/j.immuni.2009.07.008. Epub 2009 Oct 8.

PMID:
19818656
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice.

Jaiswal S, Pearson T, Friberg H, Shultz LD, Greiner DL, Rothman AL, Mathew A.

PLoS One. 2009 Oct 5;4(10):e7251. doi: 10.1371/journal.pone.0007251.

PMID:
19802382
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Priming of protective T cell responses against virus-induced tumors in mice with human immune system components.

Strowig T, Gurer C, Ploss A, Liu YF, Arrey F, Sashihara J, Koo G, Rice CM, Young JW, Chadburn A, Cohen JI, Münz C.

J Exp Med. 2009 Jun 8;206(6):1423-34. doi: 10.1084/jem.20081720. Epub 2009 Jun 1.

PMID:
19487422
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Accumulation of autoreactive effector T cells and allo-specific regulatory T cells in the pancreas allograft of a type 1 diabetic recipient.

Velthuis JH, Unger WW, van der Slik AR, Duinkerken G, Engelse M, Schaapherder AF, Ringers J, van Kooten C, de Koning EJ, Roep BO.

Diabetologia. 2009 Mar;52(3):494-503. doi: 10.1007/s00125-008-1237-z. Epub 2008 Dec 23.

PMID:
19104770
[PubMed - indexed for MEDLINE]
10.

CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope.

Skowera A, Ellis RJ, Varela-Calviño R, Arif S, Huang GC, Van-Krinks C, Zaremba A, Rackham C, Allen JS, Tree TI, Zhao M, Dayan CM, Sewell AK, Unger WW, Drijfhout JW, Ossendorp F, Roep BO, Peakman M.

J Clin Invest. 2008 Oct;118(10):3390-402. doi: 10.1172/JCI35449. Erratum in: J Clin Invest. 2009 Sep;119(9):2844. Unger, Wendy [corrected to Unger, Wendy W].

PMID:
18802479
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Weak proinsulin peptide-major histocompatibility complexes are targeted in autoimmune diabetes in mice.

Levisetti MG, Lewis DM, Suri A, Unanue ER.

Diabetes. 2008 Jul;57(7):1852-60. doi: 10.2337/db08-0068. Epub 2008 Apr 8.

PMID:
18398138
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Identification of novel IGRP epitopes targeted in type 1 diabetes patients.

Jarchum I, Nichol L, Trucco M, Santamaria P, DiLorenzo TP.

Clin Immunol. 2008 Jun;127(3):359-65. doi: 10.1016/j.clim.2008.01.015. Epub 2008 Mar 20.

PMID:
18358785
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Restoring the association of the T cell receptor with CD8 reverses anergy in human tumor-infiltrating lymphocytes.

Demotte N, Stroobant V, Courtoy PJ, Van Der Smissen P, Colau D, Luescher IF, Hivroz C, Nicaise J, Squifflet JL, Mourad M, Godelaine D, Boon T, van der Bruggen P.

Immunity. 2008 Mar;28(3):414-24. doi: 10.1016/j.immuni.2008.01.011.

PMID:
18342010
[PubMed - indexed for MEDLINE]
Free Article
14.

T-cell quality in memory and protection: implications for vaccine design.

Seder RA, Darrah PA, Roederer M.

Nat Rev Immunol. 2008 Apr;8(4):247-58. doi: 10.1038/nri2274. Epub 2008 Mar 7. Review. Erratum in: Nat Rev Immunol. 2008 Jun;8(6):486.

PMID:
18323851
[PubMed - indexed for MEDLINE]
15.

A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene.

King M, Pearson T, Shultz LD, Leif J, Bottino R, Trucco M, Atkinson MA, Wasserfall C, Herold KC, Woodland RT, Schmidt MR, Woda BA, Thompson MJ, Rossini AA, Greiner DL.

Clin Immunol. 2008 Mar;126(3):303-14. Epub 2007 Dec 21.

PMID:
18096436
[PubMed - indexed for MEDLINE]
16.

In vivo cytotoxicity of insulin-specific CD8+ T-cells in HLA-A*0201 transgenic NOD mice.

Jarchum I, Baker JC, Yamada T, Takaki T, Marron MP, Serreze DV, DiLorenzo TP.

Diabetes. 2007 Oct;56(10):2551-60. Epub 2007 Jul 9.

PMID:
17620420
[PubMed - indexed for MEDLINE]
Free Article
17.

Screening for insulitis in adult autoantibody-positive organ donors.

In't Veld P, Lievens D, De Grijse J, Ling Z, Van der Auwera B, Pipeleers-Marichal M, Gorus F, Pipeleers D.

Diabetes. 2007 Sep;56(9):2400-4. Epub 2007 Jun 11.

PMID:
17563060
[PubMed - indexed for MEDLINE]
Free Article
18.

Different T cell receptor affinity thresholds and CD8 coreceptor dependence govern cytotoxic T lymphocyte activation and tetramer binding properties.

Laugel B, van den Berg HA, Gostick E, Cole DK, Wooldridge L, Boulter J, Milicic A, Price DA, Sewell AK.

J Biol Chem. 2007 Aug 17;282(33):23799-810. Epub 2007 May 31.

PMID:
17540778
[PubMed - indexed for MEDLINE]
Free Article
19.

Human clonal CD8 autoreactivity to an IGRP islet epitope shared between mice and men.

Unger WW, Pinkse GG, Mulder-van der Kracht S, van der Slik AR, Kester MG, Ossendorp F, Drijfhout JW, Serreze DV, Roep BO.

Ann N Y Acad Sci. 2007 Apr;1103:192-5. Epub 2007 Mar 21.

PMID:
17376840
[PubMed - indexed for MEDLINE]
20.

CD8+ T-cell responses identify beta-cell autoimmunity in human type 1 diabetes.

Mallone R, Martinuzzi E, Blancou P, Novelli G, Afonso G, Dolz M, Bruno G, Chaillous L, Chatenoud L, Bach JM, van Endert P.

Diabetes. 2007 Mar;56(3):613-21.

PMID:
17327428
[PubMed - indexed for MEDLINE]
Free Article

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