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Items: 1 to 20 of 27


The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila.

Liu N, Landreh M, Cao K, Abe M, Hendriks GJ, Kennerdell JR, Zhu Y, Wang LS, Bonini NM.

Nature. 2012 Feb 15;482(7386):519-23. doi: 10.1038/nature10810.


dFOXO-independent effects of reduced insulin-like signaling in Drosophila.

Slack C, Giannakou ME, Foley A, Goss M, Partridge L.

Aging Cell. 2011 Oct;10(5):735-48. doi: 10.1111/j.1474-9726.2011.00707.x. Epub 2011 May 6.


The Drosophila FoxA ortholog Fork head regulates growth and gene expression downstream of Target of rapamycin.

Bülow MH, Aebersold R, Pankratz MJ, Jünger MA.

PLoS One. 2010 Dec 31;5(12):e15171. doi: 10.1371/journal.pone.0015171.


Extending healthy life span--from yeast to humans.

Fontana L, Partridge L, Longo VD.

Science. 2010 Apr 16;328(5976):321-6. doi: 10.1126/science.1172539. Review.


Ageing populations: the challenges ahead.

Christensen K, Doblhammer G, Rau R, Vaupel JW.

Lancet. 2009 Oct 3;374(9696):1196-208. doi: 10.1016/S0140-6736(09)61460-4. Review.


Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain.

Copeland JM, Cho J, Lo T Jr, Hur JH, Bahadorani S, Arabyan T, Rabie J, Soh J, Walker DW.

Curr Biol. 2009 Oct 13;19(19):1591-8. doi: 10.1016/j.cub.2009.08.016. Epub 2009 Sep 10.


The endosymbiont Wolbachia increases insulin/IGF-like signalling in Drosophila.

Ikeya T, Broughton S, Alic N, Grandison R, Partridge L.

Proc Biol Sci. 2009 Nov 7;276(1674):3799-807. doi: 10.1098/rspb.2009.0778. Epub 2009 Aug 19.


Expression of the Ciona intestinalis alternative oxidase (AOX) in Drosophila complements defects in mitochondrial oxidative phosphorylation.

Fernandez-Ayala DJ, Sanz A, Vartiainen S, Kemppainen KK, Babusiak M, Mustalahti E, Costa R, Tuomela T, Zeviani M, Chung J, O'Dell KM, Rustin P, Jacobs HT.

Cell Metab. 2009 May;9(5):449-60. doi: 10.1016/j.cmet.2009.03.004.


Characterization of the Drosophila gene-switch system in aging studies: a cautionary tale.

Poirier L, Shane A, Zheng J, Seroude L.

Aging Cell. 2008 Oct;7(5):758-70. doi: 10.1111/j.1474-9726.2008.00421.x. Epub 2008 Aug 1.


Optimization of dietary restriction protocols in Drosophila.

Bass TM, Grandison RC, Wong R, Martinez P, Partridge L, Piper MD.

J Gerontol A Biol Sci Med Sci. 2007 Oct;62(10):1071-81.


PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans.

Panowski SH, Wolff S, Aguilaniu H, Durieux J, Dillin A.

Nature. 2007 May 31;447(7144):550-5. Epub 2007 May 2.


Off-target effects associated with long dsRNAs in Drosophila RNAi screens.

Moffat J, Reiling JH, Sabatini DM.

Trends Pharmacol Sci. 2007 Apr;28(4):149-51. Epub 2007 Mar 9.


Alteration of Drosophila life span using conditional, tissue-specific expression of transgenes triggered by doxycyline or RU486/Mifepristone.

Ford D, Hoe N, Landis GN, Tozer K, Luu A, Bhole D, Badrinath A, Tower J.

Exp Gerontol. 2007 Jun;42(6):483-97. Epub 2007 Jan 26.


Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays.

Kulkarni MM, Booker M, Silver SJ, Friedman A, Hong P, Perrimon N, Mathey-Prevot B.

Nat Methods. 2006 Oct;3(10):833-8.


Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways.

Grimm D, Streetz KL, Jopling CL, Storm TA, Pandey K, Davis CR, Marion P, Salazar F, Kay MA.

Nature. 2006 May 25;441(7092):537-41.


Calories do not explain extension of life span by dietary restriction in Drosophila.

Mair W, Piper MD, Partridge L.

PLoS Biol. 2005 Jul;3(7):e223. Epub 2005 May 31.


A systematic RNAi screen for longevity genes in C. elegans.

Hamilton B, Dong Y, Shindo M, Liu W, Odell I, Ruvkun G, Lee SS.

Genes Dev. 2005 Jul 1;19(13):1544-55.


dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.

Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.

Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.


Long-lived Drosophila with overexpressed dFOXO in adult fat body.

Giannakou ME, Goss M, Jünger MA, Hafen E, Leevers SJ, Partridge L.

Science. 2004 Jul 16;305(5682):361. Epub 2004 Jun 10.


MicroRNAs: genomics, biogenesis, mechanism, and function.

Bartel DP.

Cell. 2004 Jan 23;116(2):281-97. Review.

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