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Items: 1 to 20 of 67

1.

Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636.

Sbrissa D, Ikonomov OC, Filios C, Delvecchio K, Shisheva A.

Am J Physiol Cell Physiol. 2012 Aug 15;303(4):C436-46. doi: 10.1152/ajpcell.00105.2012. Epub 2012 May 23.

2.

Neuronal expression of Fig4 is both necessary and sufficient to prevent spongiform neurodegeneration.

Ferguson CJ, Lenk GM, Jones JM, Grant AE, Winters JJ, Dowling JJ, Giger RJ, Meisler MH.

Hum Mol Genet. 2012 Aug 15;21(16):3525-34. doi: 10.1093/hmg/dds179. Epub 2012 May 11.

3.

Mechanisms of polarized membrane trafficking in neurons -- focusing in on endosomes.

Lasiecka ZM, Winckler B.

Mol Cell Neurosci. 2011 Dec;48(4):278-87. doi: 10.1016/j.mcn.2011.06.013. Epub 2011 Jul 2. Review.

4.

Distinctive genetic and clinical features of CMT4J: a severe neuropathy caused by mutations in the PI(3,5)P₂ phosphatase FIG4.

Nicholson G, Lenk GM, Reddel SW, Grant AE, Towne CF, Ferguson CJ, Simpson E, Scheuerle A, Yasick M, Hoffman S, Blouin R, Brandt C, Coppola G, Biesecker LG, Batish SD, Meisler MH.

Brain. 2011 Jul;134(Pt 7):1959-71. doi: 10.1093/brain/awr148.

5.

Pathogenic mechanism of the FIG4 mutation responsible for Charcot-Marie-Tooth disease CMT4J.

Lenk GM, Ferguson CJ, Chow CY, Jin N, Jones JM, Grant AE, Zolov SN, Winters JJ, Giger RJ, Dowling JJ, Weisman LS, Meisler MH.

PLoS Genet. 2011 Jun;7(6):e1002104. doi: 10.1371/journal.pgen.1002104. Epub 2011 Jun 2.

6.

Phosphoinositide [PI(3,5)P2] lipid-dependent regulation of the general transcriptional regulator Tup1.

Han BK, Emr SD.

Genes Dev. 2011 May 1;25(9):984-95. doi: 10.1101/gad.1998611.

7.

Arabidopsis FAB1A/B is possibly involved in the recycling of auxin transporters.

Hirano T, Sato MH.

Plant Signal Behav. 2011 Apr;6(4):583-5. Epub 2011 Apr 1.

8.

Distinct pathogenic processes between Fig4-deficient motor and sensory neurons.

Katona I, Zhang X, Bai Y, Shy ME, Guo J, Yan Q, Hatfield J, Kupsky WJ, Li J.

Eur J Neurosci. 2011 Apr;33(8):1401-10. doi: 10.1111/j.1460-9568.2011.07651.x. Epub 2011 Mar 17.

PMID:
21410794
9.

The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- mice.

Ikonomov OC, Sbrissa D, Delvecchio K, Xie Y, Jin JP, Rappolee D, Shisheva A.

J Biol Chem. 2011 Apr 15;286(15):13404-13. doi: 10.1074/jbc.M111.222364. Epub 2011 Feb 24.

10.

Mitochondrial and Cell Death Mechanisms in Neurodegenerative Diseases.

Martin LJ.

Pharmaceuticals (Basel). 2010;3(4):839-915.

11.

Loss-of-function and gain-of-function mutations in FAB1A/B impair endomembrane homeostasis, conferring pleiotropic developmental abnormalities in Arabidopsis.

Hirano T, Matsuzawa T, Takegawa K, Sato MH.

Plant Physiol. 2011 Feb;155(2):797-807. doi: 10.1104/pp.110.167981. Epub 2010 Dec 20.

12.

PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome.

Dong XP, Shen D, Wang X, Dawson T, Li X, Zhang Q, Cheng X, Zhang Y, Weisman LS, Delling M, Xu H.

Nat Commun. 2010 Jul 13;1:38. doi: 10.1038/ncomms1037.

13.

ArPIKfyve regulates Sac3 protein abundance and turnover: disruption of the mechanism by Sac3I41T mutation causing Charcot-Marie-Tooth 4J disorder.

Ikonomov OC, Sbrissa D, Fligger J, Delvecchio K, Shisheva A.

J Biol Chem. 2010 Aug 27;285(35):26760-4. doi: 10.1074/jbc.C110.154658. Epub 2010 Jul 14.

14.

The phosphoinositide 3-phosphatase MTMR2 interacts with PSD-95 and maintains excitatory synapses by modulating endosomal traffic.

Lee HW, Kim Y, Han K, Kim H, Kim E.

J Neurosci. 2010 Apr 21;30(16):5508-18. doi: 10.1523/JNEUROSCI.4283-09.2010.

15.

PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death.

Tsuruta F, Green EM, Rousset M, Dolmetsch RE.

J Cell Biol. 2009 Oct 19;187(2):279-94. doi: 10.1083/jcb.200903028.

16.

PIKfyve-ArPIKfyve-Sac3 core complex: contact sites and their consequence for Sac3 phosphatase activity and endocytic membrane homeostasis.

Ikonomov OC, Sbrissa D, Fenner H, Shisheva A.

J Biol Chem. 2009 Dec 18;284(51):35794-806. doi: 10.1074/jbc.M109.037515. Epub .

17.

Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2.

Ferguson CJ, Lenk GM, Meisler MH.

Hum Mol Genet. 2009 Dec 15;18(24):4868-78. doi: 10.1093/hmg/ddp460. Epub 2009 Sep 29.

18.

PIKfyve regulation of endosome-linked pathways.

de Lartigue J, Polson H, Feldman M, Shokat K, Tooze SA, Urbé S, Clague MJ.

Traffic. 2009 Jul;10(7):883-93.

19.

Molecular circuitry of endocytosis at nerve terminals.

Dittman J, Ryan TA.

Annu Rev Cell Dev Biol. 2009;25:133-60. doi: 10.1146/annurev.cellbio.042308.113302. Review.

PMID:
19575674
20.

Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca(2+) homeostasis.

Shen J, Yu WM, Brotto M, Scherman JA, Guo C, Stoddard C, Nosek TM, Valdivia HH, Qu CK.

Nat Cell Biol. 2009 Jun;11(6):769-76. doi: 10.1038/ncb1884. Epub 2009 May 24.

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