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Results: 1 to 20 of 44

1.

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health.

Chappell WH, Steelman LS, Long JM, Kempf RC, Abrams SL, Franklin RA, Bäsecke J, Stivala F, Donia M, Fagone P, Malaponte G, Mazzarino MC, Nicoletti F, Libra M, Maksimovic-Ivanic D, Mijatovic S, Montalto G, Cervello M, Laidler P, Milella M, Tafuri A, Bonati A, Evangelisti C, Cocco L, Martelli AM, McCubrey JA.

Oncotarget. 2011 Mar;2(3):135-64. Review.

PMID:
21411864
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Dual inhibition of PI3K and mTORC1/2 signaling by NVP-BEZ235 as a new therapeutic strategy for acute myeloid leukemia.

Chapuis N, Tamburini J, Green AS, Vignon C, Bardet V, Neyret A, Pannetier M, Willems L, Park S, Macone A, Maira SM, Ifrah N, Dreyfus F, Herault O, Lacombe C, Mayeux P, Bouscary D.

Clin Cancer Res. 2010 Nov 15;16(22):5424-35. doi: 10.1158/1078-0432.CCR-10-1102. Epub 2010 Sep 30.

PMID:
20884625
[PubMed - indexed for MEDLINE]
Free Article
3.

Angiosarcoma: clinical and molecular insights.

Lahat G, Dhuka AR, Hallevi H, Xiao L, Zou C, Smith KD, Phung TL, Pollock RE, Benjamin R, Hunt KK, Lazar AJ, Lev D.

Ann Surg. 2010 Jun;251(6):1098-106. doi: 10.1097/SLA.0b013e3181dbb75a.

PMID:
20485141
[PubMed - indexed for MEDLINE]
4.

Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy.

Sparks CA, Guertin DA.

Oncogene. 2010 Jul 1;29(26):3733-44. doi: 10.1038/onc.2010.139. Epub 2010 Apr 26. Review.

PMID:
20418915
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Autocrine IGF-1/IGF-1R signaling is responsible for constitutive PI3K/Akt activation in acute myeloid leukemia: therapeutic value of neutralizing anti-IGF-1R antibody.

Chapuis N, Tamburini J, Cornillet-Lefebvre P, Gillot L, Bardet V, Willems L, Park S, Green AS, Ifrah N, Dreyfus F, Mayeux P, Lacombe C, Bouscary D.

Haematologica. 2010 Mar;95(3):415-23. doi: 10.3324/haematol.2009.010785. Epub 2009 Dec 8.

PMID:
20007139
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Establishment of canine hemangiosarcoma xenograft models expressing endothelial growth factors, their receptors, and angiogenesis-associated homeobox genes.

Kodama A, Sakai H, Matsuura S, Murakami M, Murai A, Mori T, Maruo K, Kimura T, Masegi T, Yanai T.

BMC Cancer. 2009 Oct 14;9:363. doi: 10.1186/1471-2407-9-363.

PMID:
19825192
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia.

Tamburini J, Green AS, Bardet V, Chapuis N, Park S, Willems L, Uzunov M, Ifrah N, Dreyfus F, Lacombe C, Mayeux P, Bouscary D.

Blood. 2009 Aug 20;114(8):1618-27. doi: 10.1182/blood-2008-10-184515. Epub 2009 May 20.

PMID:
19458359
[PubMed - indexed for MEDLINE]
Free Article
8.

Distinct functional significance of Akt and mTOR constitutive activation in mantle cell lymphoma.

Dal Col J, Zancai P, Terrin L, Guidoboni M, Ponzoni M, Pavan A, Spina M, Bergamin S, Rizzo S, Tirelli U, De Rossi A, Doglioni C, Dolcetti R.

Blood. 2008 May 15;111(10):5142-51. doi: 10.1182/blood-2007-07-103481. Epub 2008 Mar 13.

PMID:
18339899
[PubMed - indexed for MEDLINE]
Free Article
9.

Roles for deregulated receptor tyrosine kinases and their downstream signaling molecules in hematologic malignancies.

Matsumura I, Mizuki M, Kanakura Y.

Cancer Sci. 2008 Mar;99(3):479-85. doi: 10.1111/j.1349-7006.2007.00717.x. Epub 2008 Jan 2. Review.

PMID:
18177485
[PubMed - indexed for MEDLINE]
10.

Detection and characterization of vascular endothelial growth factors and their receptors in a series of angiosarcomas.

Itakura E, Yamamoto H, Oda Y, Tsuneyoshi M.

J Surg Oncol. 2008 Jan 1;97(1):74-81.

PMID:
18041747
[PubMed - indexed for MEDLINE]
11.

Mutation of the PTEN gene in a human hepatic angiosarcoma.

Tate G, Suzuki T, Mitsuya T.

Cancer Genet Cytogenet. 2007 Oct 15;178(2):160-2.

PMID:
17954274
[PubMed - indexed for MEDLINE]
12.

Significance of the expression of phosphorylated signal transducer and activator of transcription-3, -Akt, and -cyclin D1 in angiosarcoma.

Lin N, Uchi H, Moroi Y, Fukiwake N, Dainichi T, Takeuchi S, Takahara M, Tu Y, Furue M, Urabe K.

J Dermatol Sci. 2007 Oct;48(1):64-6. No abstract available.

PMID:
17720094
[PubMed - indexed for MEDLINE]
13.

Defining the role of mTOR in cancer.

Guertin DA, Sabatini DM.

Cancer Cell. 2007 Jul;12(1):9-22. Review.

PMID:
17613433
[PubMed - indexed for MEDLINE]
Free Article
14.

The significance of p53 and retinoblastoma pathways in canine hemangiosarcoma.

Yonemaru K, Sakai H, Murakami M, Kodama A, Mori T, Yanai T, Maruo K, Masegi T.

J Vet Med Sci. 2007 Mar;69(3):271-8.

PMID:
17409643
[PubMed - indexed for MEDLINE]
Free Article
15.

Hypoxia-induced endothelial proliferation requires both mTORC1 and mTORC2.

Li W, Petrimpol M, Molle KD, Hall MN, Battegay EJ, Humar R.

Circ Res. 2007 Jan 5;100(1):79-87. Epub 2006 Nov 16.

PMID:
17110594
[PubMed - indexed for MEDLINE]
Free Article
16.

Expression of vascular endothelial growth factor, basic fibroblast growth factor, and their receptors (flt-1, flk-1, and flg-1) in canine vascular tumors.

Yonemaru K, Sakai H, Murakami M, Yanai T, Masegi T.

Vet Pathol. 2006 Nov;43(6):971-80.

PMID:
17099154
[PubMed - indexed for MEDLINE]
Free Article
17.

Angiotensin IV enhances phosphorylation of 4EBP1 by multiple signaling events in lung endothelial cells.

Lu J, Zhang J, Block ER, Patel JM.

Mol Cell Biochem. 2005 Jul;275(1-2):181-8.

PMID:
16342424
[PubMed - indexed for MEDLINE]
18.

Biological and molecular characterization of a canine hemangiosarcoma-derived cell line.

Thamm DH, Dickerson EB, Akhtar N, Lewis R, Auerbach R, Helfand SC, MacEwen EG.

Res Vet Sci. 2006 Aug;81(1):76-86. Epub 2005 Oct 25.

PMID:
16256156
[PubMed - indexed for MEDLINE]
19.

Mutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma.

Dickerson EB, Thomas R, Fosmire SP, Lamerato-Kozicki AR, Bianco SR, Wojcieszyn JW, Breen M, Helfand SC, Modiano JF.

Vet Pathol. 2005 Sep;42(5):618-32.

PMID:
16145208
[PubMed - indexed for MEDLINE]
Free Article
20.

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.

Sarbassov DD, Guertin DA, Ali SM, Sabatini DM.

Science. 2005 Feb 18;307(5712):1098-101.

PMID:
15718470
[PubMed - indexed for MEDLINE]
Free Article

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