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Results: 1 to 20 of 52

1.

The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter.

Shan J, Javitch JA, Shi L, Weinstein H.

PLoS One. 2011 Jan 27;6(1):e16350. doi: 10.1371/journal.pone.0016350.

PMID:
21298009
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Neurotransmitter/sodium symporter orthologue LeuT has a single high-affinity substrate site.

Piscitelli CL, Krishnamurthy H, Gouaux E.

Nature. 2010 Dec 23;468(7327):1129-32. doi: 10.1038/nature09581.

PMID:
21179170
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Top leads for swine influenza A/H1N1 virus revealed by steered molecular dynamics approach.

Mai BK, Viet MH, Li MS.

J Chem Inf Model. 2010 Dec 27;50(12):2236-47. doi: 10.1021/ci100346s. Epub 2010 Nov 23.

PMID:
21090736
[PubMed - indexed for MEDLINE]
4.

Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters.

Claxton DP, Quick M, Shi L, de Carvalho FD, Weinstein H, Javitch JA, McHaourab HS.

Nat Struct Mol Biol. 2010 Jul;17(7):822-9. doi: 10.1038/nsmb.1854. Epub 2010 Jun 20.

PMID:
20562855
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Homology modelling of the GABA transporter and analysis of tiagabine binding.

Skovstrup S, Taboureau O, Bräuner-Osborne H, Jørgensen FS.

ChemMedChem. 2010 Jul 5;5(7):986-1000. doi: 10.1002/cmdc.201000100.

PMID:
20491137
[PubMed - indexed for MEDLINE]
6.

Single-molecule dynamics of gating in a neurotransmitter transporter homologue.

Zhao Y, Terry D, Shi L, Weinstein H, Blanchard SC, Javitch JA.

Nature. 2010 May 13;465(7295):188-93. doi: 10.1038/nature09057.

PMID:
20463731
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Neuronal and non-neuronal GABA transporters as targets for antiepileptic drugs.

Madsen KK, White HS, Schousboe A.

Pharmacol Ther. 2010 Mar;125(3):394-401. doi: 10.1016/j.pharmthera.2009.11.007. Epub 2009 Dec 22. Review.

PMID:
20026354
[PubMed - indexed for MEDLINE]
8.

GABA transporter lysine 448: a key residue for tricyclic antidepressants interaction.

Cherubino F, Miszner A, Renna MD, Sangaletti R, Giovannardi S, Bossi E.

Cell Mol Life Sci. 2009 Dec;66(23):3797-808. doi: 10.1007/s00018-009-0153-9.

PMID:
19756379
[PubMed - indexed for MEDLINE]
9.

Mechanical signaling on the single protein level studied using steered molecular dynamics.

Genchev GZ, Källberg M, Gürsoy G, Mittal A, Dubey L, Perisic O, Feng G, Langlois R, Lu H.

Cell Biochem Biophys. 2009;55(3):141-52. doi: 10.1007/s12013-009-9064-5. Epub 2009 Aug 11. Review.

PMID:
19669741
[PubMed - indexed for MEDLINE]
10.

Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.

Zhou Z, Zhen J, Karpowich NK, Law CJ, Reith ME, Wang DN.

Nat Struct Mol Biol. 2009 Jun;16(6):652-7. doi: 10.1038/nsmb.1602. Epub 2009 May 10.

PMID:
19430461
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Synaptic and extrasynaptic GABA transporters as targets for anti-epileptic drugs.

Madsen KK, Clausen RP, Larsson OM, Krogsgaard-Larsen P, Schousboe A, White HS.

J Neurochem. 2009 May;109 Suppl 1:139-44. doi: 10.1111/j.1471-4159.2009.05982.x.

PMID:
19393020
[PubMed - indexed for MEDLINE]
12.

Elucidating conformational changes in the gamma-aminobutyric acid transporter-1.

Meinild AK, Loo DD, Skovstrup S, Gether U, MacAulay N.

J Biol Chem. 2009 Jun 12;284(24):16226-35. doi: 10.1074/jbc.M109.003137. Epub 2009 Apr 10.

PMID:
19363027
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation.

Quick M, Winther AM, Shi L, Nissen P, Weinstein H, Javitch JA.

Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5563-8. doi: 10.1073/pnas.0811322106. Epub 2009 Mar 23.

PMID:
19307590
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Location of the antidepressant binding site in the serotonin transporter: importance of Ser-438 in recognition of citalopram and tricyclic antidepressants.

Andersen J, Taboureau O, Hansen KB, Olsen L, Egebjerg J, Strømgaard K, Kristensen AS.

J Biol Chem. 2009 Apr 10;284(15):10276-84. doi: 10.1074/jbc.M806907200. Epub 2009 Feb 12.

PMID:
19213730
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

A competitive inhibitor traps LeuT in an open-to-out conformation.

Singh SK, Piscitelli CL, Yamashita A, Gouaux E.

Science. 2008 Dec 12;322(5908):1655-61. doi: 10.1126/science.1166777.

PMID:
19074341
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Mechanism for alternating access in neurotransmitter transporters.

Forrest LR, Zhang YW, Jacobs MT, Gesmonde J, Xie L, Honig BH, Rudnick G.

Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10338-43. doi: 10.1073/pnas.0804659105. Epub 2008 Jul 22.

PMID:
18647834
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding site.

Shi L, Quick M, Zhao Y, Weinstein H, Javitch JA.

Mol Cell. 2008 Jun 20;30(6):667-77. doi: 10.1016/j.molcel.2008.05.008.

PMID:
18570870
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Sodium-coupled neurotransmitter transporters.

Kanner BI, Zomot E.

Chem Rev. 2008 May;108(5):1654-68. doi: 10.1021/cr078246a. Epub 2008 Apr 5. Review. No abstract available.

PMID:
18393466
[PubMed - indexed for MEDLINE]
19.

The substrates of the gamma-aminobutyric acid transporter GAT-1 induce structural rearrangements around the interface of transmembrane domains 1 and 6.

Rosenberg A, Kanner BI.

J Biol Chem. 2008 May 23;283(21):14376-83. doi: 10.1074/jbc.M801093200. Epub 2008 Apr 1.

PMID:
18381286
[PubMed - indexed for MEDLINE]
Free Article
20.

Substrate binding and formation of an occluded state in the leucine transporter.

Celik L, Schiøtt B, Tajkhorshid E.

Biophys J. 2008 Mar 1;94(5):1600-12. Epub 2007 Nov 16.

PMID:
18024499
[PubMed - indexed for MEDLINE]
Free PMC Article

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