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Results: 1 to 20 of 65

1.

Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.

Gerlinger M, Rowan AJ, Horswell S, Larkin J, Endesfelder D, Gronroos E, Martinez P, Matthews N, Stewart A, Tarpey P, Varela I, Phillimore B, Begum S, McDonald NQ, Butler A, Jones D, Raine K, Latimer C, Santos CR, Nohadani M, Eklund AC, Spencer-Dene B, Clark G, Pickering L, Stamp G, Gore M, Szallasi Z, Downward J, Futreal PA, Swanton C.

N Engl J Med. 2012 Mar 8;366(10):883-92. doi: 10.1056/NEJMoa1113205. Erratum in: N Engl J Med. 2012 Sep 6;367(10):976.

PMID:
22397650
[PubMed - indexed for MEDLINE]
Free Article
2.

Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor.

Xu X, Hou Y, Yin X, Bao L, Tang A, Song L, Li F, Tsang S, Wu K, Wu H, He W, Zeng L, Xing M, Wu R, Jiang H, Liu X, Cao D, Guo G, Hu X, Gui Y, Li Z, Xie W, Sun X, Shi M, Cai Z, Wang B, Zhong M, Li J, Lu Z, Gu N, Zhang X, Goodman L, Bolund L, Wang J, Yang H, Kristiansen K, Dean M, Li Y, Wang J.

Cell. 2012 Mar 2;148(5):886-95. doi: 10.1016/j.cell.2012.02.025.

PMID:
22385958
[PubMed - indexed for MEDLINE]
Free Article
3.

Integrative genomic analyses of sporadic clear cell renal cell carcinoma define disease subtypes and potential new therapeutic targets.

Dondeti VR, Wubbenhorst B, Lal P, Gordan JD, D'Andrea K, Attiyeh EF, Simon MC, Nathanson KL.

Cancer Res. 2012 Jan 1;72(1):112-21. doi: 10.1158/0008-5472.CAN-11-1698. Epub 2011 Nov 17.

PMID:
22094876
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial.

Rini BI, Escudier B, Tomczak P, Kaprin A, Szczylik C, Hutson TE, Michaelson MD, Gorbunova VA, Gore ME, Rusakov IG, Negrier S, Ou YC, Castellano D, Lim HY, Uemura H, Tarazi J, Cella D, Chen C, Rosbrook B, Kim S, Motzer RJ.

Lancet. 2011 Dec 3;378(9807):1931-9. doi: 10.1016/S0140-6736(11)61613-9. Epub 2011 Nov 4. Erratum in: Lancet. 2012 Nov 24;380(9856):1818.

PMID:
22056247
[PubMed - indexed for MEDLINE]
5.

A blueprint for advancing genetics-based cancer therapy.

Sellers WR.

Cell. 2011 Sep 30;147(1):26-31. doi: 10.1016/j.cell.2011.09.016.

PMID:
21962504
[PubMed - indexed for MEDLINE]
Free Article
6.

Regulation of TFEB and V-ATPases by mTORC1.

Peña-Llopis S, Vega-Rubin-de-Celis S, Schwartz JC, Wolff NC, Tran TA, Zou L, Xie XJ, Corey DR, Brugarolas J.

EMBO J. 2011 Jul 29;30(16):3242-58. doi: 10.1038/emboj.2011.257.

PMID:
21804531
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinoma.

Kucejova B, Peña-Llopis S, Yamasaki T, Sivanand S, Tran TA, Alexander S, Wolff NC, Lotan Y, Xie XJ, Kabbani W, Kapur P, Brugarolas J.

Mol Cancer Res. 2011 Sep;9(9):1255-65. doi: 10.1158/1541-7786.MCR-11-0302. Epub 2011 Jul 28.

PMID:
21798997
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Orthotopic xenografts of RCC retain histological, immunophenotypic and genetic features of tumours in patients.

Grisanzio C, Seeley A, Chang M, Collins M, Di Napoli A, Cheng SC, Percy A, Beroukhim R, Signoretti S.

J Pathol. 2011 Oct;225(2):212-21. doi: 10.1002/path.2929. Epub 2011 Jun 27.

PMID:
21710693
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Inhibition of angiogenic and non-angiogenic targets by sorafenib in renal cell carcinoma (RCC) in a RCC xenograft model.

Yuen JS, Sim MY, Siml HG, Chong TW, Lau WK, Cheng CW, Huynh H.

Br J Cancer. 2011 Mar 15;104(6):941-7. doi: 10.1038/bjc.2011.55.

PMID:
21407223
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Exploring a glycolytic inhibitor for the treatment of an FH-deficient type-2 papillary RCC.

Yamasaki T, Tran TA, Oz OK, Raj GV, Schwarz RE, Deberardinis RJ, Zhang X, Brugarolas J.

Nat Rev Urol. 2011 Mar;8(3):165-71. doi: 10.1038/nrurol.2010.234. Epub 2011 Feb 8.

PMID:
21304509
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic death.

Kucejova B, Sunny NE, Nguyen AD, Hallac R, Fu X, Peña-Llopis S, Mason RP, Deberardinis RJ, Xie XJ, Debose-Boyd R, Kodibagkar VD, Burgess SC, Brugarolas J.

Oncogene. 2011 May 5;30(18):2147-60. doi: 10.1038/onc.2010.587. Epub 2011 Jan 10.

PMID:
21217781
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Development and characterization of clinically relevant tumor models from patients with renal cell carcinoma.

Karam JA, Zhang XY, Tamboli P, Margulis V, Wang H, Abel EJ, Culp SH, Wood CG.

Eur Urol. 2011 Apr;59(4):619-28. doi: 10.1016/j.eururo.2010.11.043. Epub 2010 Dec 8.

PMID:
21167632
[PubMed - indexed for MEDLINE]
13.

Preclinical development of molecular-targeted agents for cancer.

Ocana A, Pandiella A, Siu LL, Tannock IF.

Nat Rev Clin Oncol. 2010 Dec 7;8(4):200-9. doi: 10.1038/nrclinonc.2010.194. Review.

PMID:
21135887
[PubMed - indexed for MEDLINE]
14.

Hypoxia-inducible factors and the response to hypoxic stress.

Majmundar AJ, Wong WJ, Simon MC.

Mol Cell. 2010 Oct 22;40(2):294-309. doi: 10.1016/j.molcel.2010.09.022. Review.

PMID:
20965423
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

The mammalian target of rapamycin pathway is widely activated without PTEN deletion in renal cell carcinoma metastases.

Abou Youssif T, Fahmy MA, Koumakpayi IH, Ayala F, Al Marzooqi S, Chen G, Tamboli P, Squire J, Tanguay S, Sircar K.

Cancer. 2011 Jan 15;117(2):290-300. doi: 10.1002/cncr.25402. Epub 2010 Sep 9.

PMID:
20830770
[PubMed - indexed for MEDLINE]
Free Article
16.

Genome remodelling in a basal-like breast cancer metastasis and xenograft.

Ding L, Ellis MJ, Li S, Larson DE, Chen K, Wallis JW, Harris CC, McLellan MD, Fulton RS, Fulton LL, Abbott RM, Hoog J, Dooling DJ, Koboldt DC, Schmidt H, Kalicki J, Zhang Q, Chen L, Lin L, Wendl MC, McMichael JF, Magrini VJ, Cook L, McGrath SD, Vickery TL, Appelbaum E, Deschryver K, Davies S, Guintoli T, Lin L, Crowder R, Tao Y, Snider JE, Smith SM, Dukes AF, Sanderson GE, Pohl CS, Delehaunty KD, Fronick CC, Pape KA, Reed JS, Robinson JS, Hodges JS, Schierding W, Dees ND, Shen D, Locke DP, Wiechert ME, Eldred JM, Peck JB, Oberkfell BJ, Lolofie JT, Du F, Hawkins AE, O'Laughlin MD, Bernard KE, Cunningham M, Elliott G, Mason MD, Thompson DM Jr, Ivanovich JL, Goodfellow PJ, Perou CM, Weinstock GM, Aft R, Watson M, Ley TJ, Wilson RK, Mardis ER.

Nature. 2010 Apr 15;464(7291):999-1005. doi: 10.1038/nature08989.

PMID:
20393555
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Anticancer drug development: the grand challenges.

Hait WN.

Nat Rev Drug Discov. 2010 Apr;9(4):253-4. doi: 10.1038/nrd3144.

PMID:
20369394
[PubMed - indexed for MEDLINE]
18.

Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: final results of CALGB 90206.

Rini BI, Halabi S, Rosenberg JE, Stadler WM, Vaena DA, Archer L, Atkins JN, Picus J, Czaykowski P, Dutcher J, Small EJ.

J Clin Oncol. 2010 May 1;28(13):2137-43. doi: 10.1200/JCO.2009.26.5561. Epub 2010 Apr 5.

PMID:
20368558
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): final analysis of overall survival.

Escudier B, Bellmunt J, Négrier S, Bajetta E, Melichar B, Bracarda S, Ravaud A, Golding S, Jethwa S, Sneller V.

J Clin Oncol. 2010 May 1;28(13):2144-50. doi: 10.1200/JCO.2009.26.7849. Epub 2010 Apr 5.

PMID:
20368553
[PubMed - indexed for MEDLINE]
20.

The landscape of somatic copy-number alteration across human cancers.

Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, Donovan J, Barretina J, Boehm JS, Dobson J, Urashima M, Mc Henry KT, Pinchback RM, Ligon AH, Cho YJ, Haery L, Greulich H, Reich M, Winckler W, Lawrence MS, Weir BA, Tanaka KE, Chiang DY, Bass AJ, Loo A, Hoffman C, Prensner J, Liefeld T, Gao Q, Yecies D, Signoretti S, Maher E, Kaye FJ, Sasaki H, Tepper JE, Fletcher JA, Tabernero J, Baselga J, Tsao MS, Demichelis F, Rubin MA, Janne PA, Daly MJ, Nucera C, Levine RL, Ebert BL, Gabriel S, Rustgi AK, Antonescu CR, Ladanyi M, Letai A, Garraway LA, Loda M, Beer DG, True LD, Okamoto A, Pomeroy SL, Singer S, Golub TR, Lander ES, Getz G, Sellers WR, Meyerson M.

Nature. 2010 Feb 18;463(7283):899-905. doi: 10.1038/nature08822.

PMID:
20164920
[PubMed - indexed for MEDLINE]
Free PMC Article

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