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Results: 19

1.

A continuum model for tumour suppression.

Berger AH, Knudson AG, Pandolfi PP.

Nature. 2011 Aug 10;476(7359):163-9. doi: 10.1038/nature10275. Review.

PMID:
21833082
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034.

van den Bent MJ, Brandes AA, Rampling R, Kouwenhoven MC, Kros JM, Carpentier AF, Clement PM, Frenay M, Campone M, Baurain JF, Armand JP, Taphoorn MJ, Tosoni A, Kletzl H, Klughammer B, Lacombe D, Gorlia T.

J Clin Oncol. 2009 Mar 10;27(8):1268-74. doi: 10.1200/JCO.2008.17.5984. Epub 2009 Feb 9.

PMID:
19204207
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177.

Brown PD, Krishnan S, Sarkaria JN, Wu W, Jaeckle KA, Uhm JH, Geoffroy FJ, Arusell R, Kitange G, Jenkins RB, Kugler JW, Morton RF, Rowland KM Jr, Mischel P, Yong WH, Scheithauer BW, Schiff D, Giannini C, Buckner JC; North Central Cancer Treatment Group Study N0177.

J Clin Oncol. 2008 Dec 1;26(34):5603-9. doi: 10.1200/JCO.2008.18.0612. Epub 2008 Oct 27.

PMID:
18955445
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

EGFR antagonists in cancer treatment.

Ciardiello F, Tortora G.

N Engl J Med. 2008 Mar 13;358(11):1160-74. doi: 10.1056/NEJMra0707704. Review. No abstract available. Erratum in: N Engl J Med. 2009 Apr 9;360(15):1579.

PMID:
18337605
[PubMed - indexed for MEDLINE]
5.

Mechanisms for oncogenic activation of the epidermal growth factor receptor.

Zandi R, Larsen AB, Andersen P, Stockhausen MT, Poulsen HS.

Cell Signal. 2007 Oct;19(10):2013-23. Epub 2007 Jul 4. Review.

PMID:
17681753
[PubMed - indexed for MEDLINE]
6.

Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity.

Yun CH, Boggon TJ, Li Y, Woo MS, Greulich H, Meyerson M, Eck MJ.

Cancer Cell. 2007 Mar;11(3):217-27.

PMID:
17349580
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Structure-guided development of affinity probes for tyrosine kinases using chemical genetics.

Blair JA, Rauh D, Kung C, Yun CH, Fan QW, Rode H, Zhang C, Eck MJ, Weiss WA, Shokat KM.

Nat Chem Biol. 2007 Apr;3(4):229-38. Epub 2007 Mar 4.

PMID:
17334377
[PubMed - indexed for MEDLINE]
8.

Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors.

Ji H, Zhao X, Yuza Y, Shimamura T, Li D, Protopopov A, Jung BL, McNamara K, Xia H, Glatt KA, Thomas RK, Sasaki H, Horner JW, Eck M, Mitchell A, Sun Y, Al-Hashem R, Bronson RT, Rabindran SK, Discafani CM, Maher E, Shapiro GI, Meyerson M, Wong KK.

Proc Natl Acad Sci U S A. 2006 May 16;103(20):7817-22. Epub 2006 May 3.

PMID:
16672372
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

Mellinghoff IK, Wang MY, Vivanco I, Haas-Kogan DA, Zhu S, Dia EQ, Lu KV, Yoshimoto K, Huang JH, Chute DJ, Riggs BL, Horvath S, Liau LM, Cavenee WK, Rao PN, Beroukhim R, Peck TC, Lee JC, Sellers WR, Stokoe D, Prados M, Cloughesy TF, Sawyers CL, Mischel PS.

N Engl J Med. 2005 Nov 10;353(19):2012-24. Erratum in: N Engl J Med. 2006 Feb 23;354(8):884.

PMID:
16282176
[PubMed - indexed for MEDLINE]
Free Article
10.

Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain.

Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF, Kris MG, Varmus H.

PLoS Med. 2005 Mar;2(3):e73. Epub 2005 Feb 22.

PMID:
15737014
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

EGFR mutation and resistance of non-small-cell lung cancer to gefitinib.

Kobayashi S, Boggon TJ, Dayaram T, Jänne PA, Kocher O, Meyerson M, Johnson BE, Eck MJ, Tenen DG, Halmos B.

N Engl J Med. 2005 Feb 24;352(8):786-92.

PMID:
15728811
[PubMed - indexed for MEDLINE]
Free Article
12.

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.

Paez JG, Jänne PA, Lee JC, Tracy S, Greulich H, Gabriel S, Herman P, Kaye FJ, Lindeman N, Boggon TJ, Naoki K, Sasaki H, Fujii Y, Eck MJ, Sellers WR, Johnson BE, Meyerson M.

Science. 2004 Jun 4;304(5676):1497-500. Epub 2004 Apr 29.

PMID:
15118125
[PubMed - indexed for MEDLINE]
Free Article
13.

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.

Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, Harris PL, Haserlat SM, Supko JG, Haluska FG, Louis DN, Christiani DC, Settleman J, Haber DA.

N Engl J Med. 2004 May 20;350(21):2129-39. Epub 2004 Apr 29.

PMID:
15118073
[PubMed - indexed for MEDLINE]
Free Article
14.

ErbB-targeted therapeutic approaches in human cancer.

Arteaga CL.

Exp Cell Res. 2003 Mar 10;284(1):122-30. Review.

PMID:
12648471
[PubMed - indexed for MEDLINE]
15.

The ErbB receptors and their role in cancer progression.

Holbro T, Civenni G, Hynes NE.

Exp Cell Res. 2003 Mar 10;284(1):99-110. Review.

PMID:
12648469
[PubMed - indexed for MEDLINE]
16.

Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas.

Frederick L, Wang XY, Eley G, James CD.

Cancer Res. 2000 Mar 1;60(5):1383-7.

PMID:
10728703
[PubMed - indexed for MEDLINE]
Free Article
17.

Structure-based design of a potent, selective, and irreversible inhibitor of the catalytic domain of the erbB receptor subfamily of protein tyrosine kinases.

Singh J, Dobrusin EM, Fry DW, Haske T, Whitty A, McNamara DJ.

J Med Chem. 1997 Mar 28;40(7):1130-5.

PMID:
9089334
[PubMed - indexed for MEDLINE]
18.

The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling.

Huang HS, Nagane M, Klingbeil CK, Lin H, Nishikawa R, Ji XD, Huang CM, Gill GN, Wiley HS, Cavenee WK.

J Biol Chem. 1997 Jan 31;272(5):2927-35.

PMID:
9006938
[PubMed - indexed for MEDLINE]
Free Article
19.

Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas.

Sugawa N, Ekstrand AJ, James CD, Collins VP.

Proc Natl Acad Sci U S A. 1990 Nov;87(21):8602-6.

PMID:
2236070
[PubMed - indexed for MEDLINE]
Free PMC Article

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