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Results: 1 to 20 of 46

1.

A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis.

Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, Schmitt EM, Skinner SO, Xu Q, Li MZ, Hartman ZC, Rao M, Yu P, Dominguez-Vidana R, Liang AC, Solimini NL, Bernardi RJ, Yu B, Hsu T, Golding I, Luo J, Osborne CK, Creighton CJ, Hilsenbeck SG, Schiff R, Shaw CA, Elledge SJ, Westbrook TF.

Science. 2012 Jan 20;335(6066):348-53. doi: 10.1126/science.1212728. Epub 2011 Dec 8.

PMID:
22157079
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Targeting MYC dependence in cancer by inhibiting BET bromodomains.

Mertz JA, Conery AR, Bryant BM, Sandy P, Balasubramanian S, Mele DA, Bergeron L, Sims RJ 3rd.

Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16669-74. doi: 10.1073/pnas.1108190108. Epub 2011 Sep 26.

PMID:
21949397
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis.

Ilic N, Utermark T, Widlund HR, Roberts TM.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):E699-708. doi: 10.1073/pnas.1108237108. Epub 2011 Aug 29.

PMID:
21876152
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia.

Zuber J, Shi J, Wang E, Rappaport AR, Herrmann H, Sison EA, Magoon D, Qi J, Blatt K, Wunderlich M, Taylor MJ, Johns C, Chicas A, Mulloy JC, Kogan SC, Brown P, Valent P, Bradner JE, Lowe SW, Vakoc CR.

Nature. 2011 Aug 3;478(7370):524-8. doi: 10.1038/nature10334.

PMID:
21814200
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Characterization of silvestrol pharmacokinetics in mice using liquid chromatography-tandem mass spectrometry.

Saradhi UV, Gupta SV, Chiu M, Wang J, Ling Y, Liu Z, Newman DJ, Covey JM, Kinghorn AD, Marcucci G, Lucas DM, Grever MR, Phelps MA, Chan KK.

AAPS J. 2011 Sep;13(3):347-56. doi: 10.1208/s12248-011-9273-x. Epub 2011 Apr 16.

PMID:
21499689
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Reversible suppression of an essential gene in adult mice using transgenic RNA interference.

McJunkin K, Mazurek A, Premsrirut PK, Zuber J, Dow LE, Simon J, Stillman B, Lowe SW.

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7113-8. doi: 10.1073/pnas.1104097108. Epub 2011 Apr 11.

PMID:
21482754
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

A rapid and scalable system for studying gene function in mice using conditional RNA interference.

Premsrirut PK, Dow LE, Kim SY, Camiolo M, Malone CD, Miething C, Scuoppo C, Zuber J, Dickins RA, Kogan SC, Shroyer KR, Sordella R, Hannon GJ, Lowe SW.

Cell. 2011 Apr 1;145(1):145-58. doi: 10.1016/j.cell.2011.03.012.

PMID:
21458673
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Effects of hippuristanol, an inhibitor of eIF4A, on adult T-cell leukemia.

Tsumuraya T, Ishikawa C, Machijima Y, Nakachi S, Senba M, Tanaka J, Mori N.

Biochem Pharmacol. 2011 Mar 15;81(6):713-22. doi: 10.1016/j.bcp.2010.12.025. Epub 2011 Jan 8.

PMID:
21219881
[PubMed - indexed for MEDLINE]
9.

MYC as a regulator of ribosome biogenesis and protein synthesis.

van Riggelen J, Yetil A, Felsher DW.

Nat Rev Cancer. 2010 Apr;10(4):301-9. doi: 10.1038/nrc2819. Review.

PMID:
20332779
[PubMed - indexed for MEDLINE]
10.

The landscape of somatic copy-number alteration across human cancers.

Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, Donovan J, Barretina J, Boehm JS, Dobson J, Urashima M, Mc Henry KT, Pinchback RM, Ligon AH, Cho YJ, Haery L, Greulich H, Reich M, Winckler W, Lawrence MS, Weir BA, Tanaka KE, Chiang DY, Bass AJ, Loo A, Hoffman C, Prensner J, Liefeld T, Gao Q, Yecies D, Signoretti S, Maher E, Kaye FJ, Sasaki H, Tepper JE, Fletcher JA, Tabernero J, Baselga J, Tsao MS, Demichelis F, Rubin MA, Janne PA, Daly MJ, Nucera C, Levine RL, Ebert BL, Gabriel S, Rustgi AK, Antonescu CR, Ladanyi M, Letai A, Garraway LA, Loda M, Beer DG, True LD, Okamoto A, Pomeroy SL, Singer S, Golub TR, Lander ES, Getz G, Sellers WR, Meyerson M.

Nature. 2010 Feb 18;463(7283):899-905. doi: 10.1038/nature08822.

PMID:
20164920
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol.

Cencic R, Carrier M, Galicia-Vázquez G, Bordeleau ME, Sukarieh R, Bourdeau A, Brem B, Teodoro JG, Greger H, Tremblay ML, Porco JA Jr, Pelletier J.

PLoS One. 2009;4(4):e5223. doi: 10.1371/journal.pone.0005223. Epub 2009 Apr 29.

PMID:
19401772
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo.

Lucas DM, Edwards RB, Lozanski G, West DA, Shin JD, Vargo MA, Davis ME, Rozewski DM, Johnson AJ, Su BN, Goettl VM, Heerema NA, Lin TS, Lehman A, Zhang X, Jarjoura D, Newman DJ, Byrd JC, Kinghorn AD, Grever MR.

Blood. 2009 May 7;113(19):4656-66. doi: 10.1182/blood-2008-09-175430. Epub 2009 Feb 3.

PMID:
19190247
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Modelling Myc inhibition as a cancer therapy.

Soucek L, Whitfield J, Martins CP, Finch AJ, Murphy DJ, Sodir NM, Karnezis AN, Swigart LB, Nasi S, Evan GI.

Nature. 2008 Oct 2;455(7213):679-83. doi: 10.1038/nature07260. Epub 2008 Aug 17.

PMID:
18716624
[PubMed - indexed for MEDLINE]
14.

mTORC1 promotes survival through translational control of Mcl-1.

Mills JR, Hippo Y, Robert F, Chen SM, Malina A, Lin CJ, Trojahn U, Wendel HG, Charest A, Bronson RT, Kogan SC, Nadon R, Housman DE, Lowe SW, Pelletier J.

Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10853-8. doi: 10.1073/pnas.0804821105. Epub 2008 Jul 29.

PMID:
18664580
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

c-Myc and eIF4F are components of a feedforward loop that links transcription and translation.

Lin CJ, Cencic R, Mills JR, Robert F, Pelletier J.

Cancer Res. 2008 Jul 1;68(13):5326-34. doi: 10.1158/0008-5472.CAN-07-5876. Erratum in: Cancer Res. 2008 Sep 1;68(17):7246.

PMID:
18593934
[PubMed - indexed for MEDLINE]
Free Article
16.

Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model.

Bordeleau ME, Robert F, Gerard B, Lindqvist L, Chen SM, Wendel HG, Brem B, Greger H, Lowe SW, Porco JA Jr, Pelletier J.

J Clin Invest. 2008 Jul;118(7):2651-60. doi: 10.1172/JCI34753.

PMID:
18551192
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras.

Podsypanina K, Politi K, Beverly LJ, Varmus HE.

Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5242-7. doi: 10.1073/pnas.0801197105. Epub 2008 Mar 20.

PMID:
18356293
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Dissecting eIF4E action in tumorigenesis.

Wendel HG, Silva RL, Malina A, Mills JR, Zhu H, Ueda T, Watanabe-Fukunaga R, Fukunaga R, Teruya-Feldstein J, Pelletier J, Lowe SW.

Genes Dev. 2007 Dec 15;21(24):3232-7. Epub 2007 Nov 30.

PMID:
18055695
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity.

Graff JR, Konicek BW, Vincent TM, Lynch RL, Monteith D, Weir SN, Schwier P, Capen A, Goode RL, Dowless MS, Chen Y, Zhang H, Sissons S, Cox K, McNulty AM, Parsons SH, Wang T, Sams L, Geeganage S, Douglass LE, Neubauer BL, Dean NM, Blanchard K, Shou J, Stancato LF, Carter JH, Marcusson EG.

J Clin Invest. 2007 Sep;117(9):2638-48.

PMID:
17786246
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Eukaryotic translation initiation factor 4E induced progression of primary human mammary epithelial cells along the cancer pathway is associated with targeted translational deregulation of oncogenic drivers and inhibitors.

Larsson O, Li S, Issaenko OA, Avdulov S, Peterson M, Smith K, Bitterman PB, Polunovsky VA.

Cancer Res. 2007 Jul 15;67(14):6814-24.

PMID:
17638893
[PubMed - indexed for MEDLINE]
Free Article
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