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Results: 1 to 20 of 31

1.

Synthesis and study of 2-amino-7-bromofluorenes modified with nitroxides and their precursors as dual anti-amyloid and antioxidant active compounds.

Kálai T, Petrlova J, Balog M, Aung HH, Voss JC, Hideg K.

Eur J Med Chem. 2011 Apr;46(4):1348-55. doi: 10.1016/j.ejmech.2011.01.059. Epub 2011 Feb 3.

PMID:
21333407
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Alzheimer's disease drug candidates stabilize A-β protein native structure by interacting with the hydrophobic core.

Li J, Liu R, Lam KS, Jin LW, Duan Y.

Biophys J. 2011 Feb 16;100(4):1076-82. doi: 10.1016/j.bpj.2010.12.3741.

PMID:
21320453
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

A differential association of Apolipoprotein E isoforms with the amyloid-β oligomer in solution.

Petrlova J, Hong HS, Bricarello DA, Harishchandra G, Lorigan GA, Jin LW, Voss JC.

Proteins. 2011 Feb;79(2):402-16. doi: 10.1002/prot.22891.

PMID:
21069870
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Fibrillar oligomers nucleate the oligomerization of monomeric amyloid beta but do not seed fibril formation.

Wu JW, Breydo L, Isas JM, Lee J, Kuznetsov YG, Langen R, Glabe C.

J Biol Chem. 2010 Feb 26;285(9):6071-9. doi: 10.1074/jbc.M109.069542. Epub 2009 Dec 15.

PMID:
20018889
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Inhibition of Alzheimer's amyloid toxicity with a tricyclic pyrone molecule in vitro and in vivo.

Hong HS, Rana S, Barrigan L, Shi A, Zhang Y, Zhou F, Jin LW, Hua DH.

J Neurochem. 2009 Feb;108(4):1097-1108. doi: 10.1111/j.1471-4159.2008.05866.x.

PMID:
19141069
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Candidate anti-A beta fluorene compounds selected from analogs of amyloid imaging agents.

Hong HS, Maezawa I, Budamagunta M, Rana S, Shi A, Vassar R, Liu R, Lam KS, Cheng RH, Hua DH, Voss JC, Jin LW.

Neurobiol Aging. 2010 Oct;31(10):1690-9. doi: 10.1016/j.neurobiolaging.2008.09.019. Epub 2008 Nov 20.

PMID:
19022536
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Nitric oxide and nitroxides can act as efficient scavengers of protein-derived free radicals.

Lam MA, Pattison DI, Bottle SE, Keddie DJ, Davies MJ.

Chem Res Toxicol. 2008 Nov;21(11):2111-9. doi: 10.1021/tx800183t.

PMID:
18834151
[PubMed - indexed for MEDLINE]
8.

Congo red and thioflavin-T analogs detect Abeta oligomers.

Maezawa I, Hong HS, Liu R, Wu CY, Cheng RH, Kung MP, Kung HF, Lam KS, Oddo S, Laferla FM, Jin LW.

J Neurochem. 2008 Jan;104(2):457-68. Epub 2007 Oct 22.

PMID:
17953662
[PubMed - indexed for MEDLINE]
9.

Novel antioxidants in anthracycline cardiotoxicity.

Hideg K, Kálai T.

Cardiovasc Toxicol. 2007;7(2):160-4. Review.

PMID:
17652823
[PubMed - indexed for MEDLINE]
10.

N-hydroxy-pyrroline modification of verapamil exhibits antioxidant protection of the heart against ischemia/reperfusion-induced cardiac dysfunction without compromising its calcium antagonistic activity.

Mandal R, Kutala VK, Khan M, Mohan IK, Varadharaj S, Sridhar A, Carnes CA, Kálai T, Hideg K, Kuppusamy P.

J Pharmacol Exp Ther. 2007 Oct;323(1):119-27. Epub 2007 Jul 23.

PMID:
17646427
[PubMed - indexed for MEDLINE]
Free Article
11.

Intracellular amyloid-beta in Alzheimer's disease.

LaFerla FM, Green KN, Oddo S.

Nat Rev Neurosci. 2007 Jul;8(7):499-509. Review.

PMID:
17551515
[PubMed - indexed for MEDLINE]
12.

The correlation between neurotoxicity, aggregative ability and secondary structure studied by sequence truncated Abeta peptides.

Liao MQ, Tzeng YJ, Chang LY, Huang HB, Lin TH, Chyan CL, Chen YC.

FEBS Lett. 2007 Mar 20;581(6):1161-5. Epub 2007 Feb 20.

PMID:
17328898
[PubMed - indexed for MEDLINE]
Free Article
13.

Radioligand development for PET imaging of beta-amyloid (Abeta)--current status.

Cai L, Innis RB, Pike VW.

Curr Med Chem. 2007;14(1):19-52. Erratum in: Curr Med Chem. 2007;14(15):1701.

PMID:
17266566
[PubMed - indexed for MEDLINE]
14.

Blood-brain barrier delivery.

Pardridge WM.

Drug Discov Today. 2007 Jan;12(1-2):54-61. Epub 2006 Nov 13. Review.

PMID:
17198973
[PubMed - indexed for MEDLINE]
15.

Combining the rapid MTT formazan exocytosis assay and the MC65 protection assay led to the discovery of carbazole analogs as small molecule inhibitors of Abeta oligomer-induced cytotoxicity.

Hong HS, Maezawa I, Yao N, Xu B, Diaz-Avalos R, Rana S, Hua DH, Cheng RH, Lam KS, Jin LW.

Brain Res. 2007 Jan 26;1130(1):223-34. Epub 2006 Dec 8.

PMID:
17157826
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases.

Lin MT, Beal MF.

Nature. 2006 Oct 19;443(7113):787-95. Review.

PMID:
17051205
[PubMed - indexed for MEDLINE]
17.

A novel tricyclic pyrone compound ameliorates cell death associated with intracellular amyloid-beta oligomeric complexes.

Maezawa I, Hong HS, Wu HC, Battina SK, Rana S, Iwamoto T, Radke GA, Pettersson E, Martin GM, Hua DH, Jin LW.

J Neurochem. 2006 Jul;98(1):57-67.

PMID:
16805796
[PubMed - indexed for MEDLINE]
18.

A specific amyloid-beta protein assembly in the brain impairs memory.

Lesné S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, Gallagher M, Ashe KH.

Nature. 2006 Mar 16;440(7082):352-7.

PMID:
16541076
[PubMed - indexed for MEDLINE]
19.

Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond.

Lipton SA.

Nat Rev Drug Discov. 2006 Feb;5(2):160-70. Review.

PMID:
16424917
[PubMed - indexed for MEDLINE]
20.

How to study proteins by circular dichroism.

Kelly SM, Jess TJ, Price NC.

Biochim Biophys Acta. 2005 Aug 10;1751(2):119-39. Review.

PMID:
16027053
[PubMed - indexed for MEDLINE]
Free Article

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