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Results: 1 to 20 of 67

1.

Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations.

Quintero-Monzon O, Martin MM, Fernandez MA, Cappello CA, Krzysiak AJ, Osenkowski P, Wolfe MS.

Biochemistry. 2011 Oct 25;50(42):9023-35. doi: 10.1021/bi2007146. Epub 2011 Sep 30.

PMID:
21919498
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Potent amyloidogenicity and pathogenicity of Aβ43.

Saito T, Suemoto T, Brouwers N, Sleegers K, Funamoto S, Mihira N, Matsuba Y, Yamada K, Nilsson P, Takano J, Nishimura M, Iwata N, Van Broeckhoven C, Ihara Y, Saido TC.

Nat Neurosci. 2011 Jul 3;14(8):1023-32. doi: 10.1038/nn.2858.

PMID:
21725313
[PubMed - indexed for MEDLINE]
3.

Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation.

Zhou L, Brouwers N, Benilova I, Vandersteen A, Mercken M, Van Laere K, Van Damme P, Demedts D, Van Leuven F, Sleegers K, Broersen K, Van Broeckhoven C, Vandenberghe R, De Strooper B.

EMBO Mol Med. 2011 May;3(5):291-302. doi: 10.1002/emmm.201100138. Epub 2011 Apr 15.

PMID:
21500352
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

PSENEN and NCSTN mutations in familial hidradenitis suppurativa (Acne Inversa).

Pink AE, Simpson MA, Brice GW, Smith CH, Desai N, Mortimer PS, Barker JN, Trembath RC.

J Invest Dermatol. 2011 Jul;131(7):1568-70. doi: 10.1038/jid.2011.42. Epub 2011 Mar 17. No abstract available.

PMID:
21412258
[PubMed - indexed for MEDLINE]
Free Article
5.

γ-Secretase modulators as potential disease modifying anti-Alzheimer's drugs.

Oehlrich D, Berthelot DJ, Gijsen HJ.

J Med Chem. 2011 Feb 10;54(3):669-98. doi: 10.1021/jm101168r. Epub 2010 Dec 9. Review. No abstract available.

PMID:
21141968
[PubMed - indexed for MEDLINE]
6.

Genetics. Gamma-secretase and human disease.

Kelleher RJ 3rd, Shen J.

Science. 2010 Nov 19;330(6007):1055-6. doi: 10.1126/science.1198668. No abstract available.

PMID:
21097925
[PubMed - indexed for MEDLINE]
7.

Gamma-secretase gene mutations in familial acne inversa.

Wang B, Yang W, Wen W, Sun J, Su B, Liu B, Ma D, Lv D, Wen Y, Qu T, Chen M, Sun M, Shen Y, Zhang X.

Science. 2010 Nov 19;330(6007):1065. doi: 10.1126/science.1196284. Epub 2010 Oct 7.

PMID:
20929727
[PubMed - indexed for MEDLINE]
Free Article
8.

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio.

Kuperstein I, Broersen K, Benilova I, Rozenski J, Jonckheere W, Debulpaep M, Vandersteen A, Segers-Nolten I, Van Der Werf K, Subramaniam V, Braeken D, Callewaert G, Bartic C, D'Hooge R, Martins IC, Rousseau F, Schymkowitz J, De Strooper B.

EMBO J. 2010 Oct 6;29(19):3408-20. doi: 10.1038/emboj.2010.211. Epub 2010 Sep 3.

PMID:
20818335
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Novel research horizons for presenilins and γ-secretases in cell biology and disease.

De Strooper B, Annaert W.

Annu Rev Cell Dev Biol. 2010;26:235-60. doi: 10.1146/annurev-cellbio-100109-104117. Review.

PMID:
20604710
[PubMed - indexed for MEDLINE]
10.

Role of presenilins in neuronal calcium homeostasis.

Zhang H, Sun S, Herreman A, De Strooper B, Bezprozvanny I.

J Neurosci. 2010 Jun 23;30(25):8566-80. doi: 10.1523/JNEUROSCI.1554-10.2010.

PMID:
20573903
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations.

Lee JH, Yu WH, Kumar A, Lee S, Mohan PS, Peterhoff CM, Wolfe DM, Martinez-Vicente M, Massey AC, Sovak G, Uchiyama Y, Westaway D, Cuervo AM, Nixon RA.

Cell. 2010 Jun 25;141(7):1146-58. doi: 10.1016/j.cell.2010.05.008. Epub 2010 Jun 10.

PMID:
20541250
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.

Fukumori A, Fluhrer R, Steiner H, Haass C.

J Neurosci. 2010 Jun 9;30(23):7853-62. doi: 10.1523/JNEUROSCI.1443-10.2010.

PMID:
20534834
[PubMed - indexed for MEDLINE]
Free Article
13.

A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity.

Heilig EA, Xia W, Shen J, Kelleher RJ 3rd.

J Biol Chem. 2010 Jul 16;285(29):22350-9. doi: 10.1074/jbc.M110.116962. Epub 2010 May 11.

PMID:
20460383
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase.

Watanabe N, Image Image II, Takagi S, Image Image II, Tominaga A, Image Image I, Tomita T, Image Image II, Iwatsubo T, Image Image I.

J Biol Chem. 2010 Jun 25;285(26):19738-46. doi: 10.1074/jbc.M110.101287. Epub 2010 Apr 23.

PMID:
20418378
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Distinct cerebrospinal fluid amyloid beta peptide signatures in sporadic and PSEN1 A431E-associated familial Alzheimer's disease.

Portelius E, Andreasson U, Ringman JM, Buerger K, Daborg J, Buchhave P, Hansson O, Harmsen A, Gustavsson MK, Hanse E, Galasko D, Hampel H, Blennow K, Zetterberg H.

Mol Neurodegener. 2010 Jan 14;5:2. doi: 10.1186/1750-1326-5-2.

PMID:
20145736
[PubMed]
Free PMC Article
16.

The secretases: enzymes with therapeutic potential in Alzheimer disease.

De Strooper B, Vassar R, Golde T.

Nat Rev Neurol. 2010 Feb;6(2):99-107. doi: 10.1038/nrneurol.2009.218. Review.

PMID:
20139999
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

gamma-secretases: from cell biology to therapeutic strategies.

Bergmans BA, De Strooper B.

Lancet Neurol. 2010 Feb;9(2):215-26. doi: 10.1016/S1474-4422(09)70332-1. Review.

PMID:
20129170
[PubMed - indexed for MEDLINE]
18.

gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment.

Takami M, Nagashima Y, Sano Y, Ishihara S, Morishima-Kawashima M, Funamoto S, Ihara Y.

J Neurosci. 2009 Oct 14;29(41):13042-52. doi: 10.1523/JNEUROSCI.2362-09.2009.

PMID:
19828817
[PubMed - indexed for MEDLINE]
Free Article
19.

Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.

Martone RL, Zhou H, Atchison K, Comery T, Xu JZ, Huang X, Gong X, Jin M, Kreft A, Harrison B, Mayer SC, Aschmies S, Gonzales C, Zaleska MM, Riddell DR, Wagner E, Lu P, Sun SC, Sonnenberg-Reines J, Oganesian A, Adkins K, Leach MW, Clarke DW, Huryn D, Abou-Gharbia M, Magolda R, Bard J, Frick G, Raje S, Forlow SB, Balliet C, Burczynski ME, Reinhart PH, Wan HI, Pangalos MN, Jacobsen JS.

J Pharmacol Exp Ther. 2009 Nov;331(2):598-608. doi: 10.1124/jpet.109.152975. Epub 2009 Aug 11.

PMID:
19671883
[PubMed - indexed for MEDLINE]
Free Article
20.

Abeta43 is more frequent than Abeta40 in amyloid plaque cores from Alzheimer disease brains.

Welander H, Frånberg J, Graff C, Sundström E, Winblad B, Tjernberg LO.

J Neurochem. 2009 Jul;110(2):697-706. doi: 10.1111/j.1471-4159.2009.06170.x. Epub 2009 May 15.

PMID:
19457079
[PubMed - indexed for MEDLINE]

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