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Results: 1 to 20 of 22

1.

Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry.

Chen J, Young SM, Allen C, Seeber A, Péli-Gulli MP, Panchaud N, Waller A, Ursu O, Yao T, Golden JE, Strouse JJ, Carter MB, Kang H, Bologa CG, Foutz TD, Edwards BS, Peterson BR, Aubé J, Werner-Washburne M, Loewith RJ, De Virgilio C, Sklar LA.

ACS Chem Biol. 2012 Apr 20;7(4):715-22. doi: 10.1021/cb200452r. Epub 2012 Feb 1.

PMID:
22260433
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Design, synthesis, and characterization of a highly effective Hog1 inhibitor: a powerful tool for analyzing MAP kinase signaling in yeast.

Dinér P, Veide Vilg J, Kjellén J, Migdal I, Andersson T, Gebbia M, Giaever G, Nislow C, Hohmann S, Wysocki R, Tamás MJ, Grøtli M.

PLoS One. 2011;6(5):e20012. doi: 10.1371/journal.pone.0020012. Epub 2011 May 31.

PMID:
21655328
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer.

Liu Q, Chang JW, Wang J, Kang SA, Thoreen CC, Markhard A, Hur W, Zhang J, Sim T, Sabatini DM, Gray NS.

J Med Chem. 2010 Oct 14;53(19):7146-55. doi: 10.1021/jm101144f.

PMID:
20860370
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity.

Chresta CM, Davies BR, Hickson I, Harding T, Cosulich S, Critchlow SE, Vincent JP, Ellston R, Jones D, Sini P, James D, Howard Z, Dudley P, Hughes G, Smith L, Maguire S, Hummersone M, Malagu K, Menear K, Jenkins R, Jacobsen M, Smith GC, Guichard S, Pass M.

Cancer Res. 2010 Jan 1;70(1):288-98. doi: 10.1158/0008-5472.CAN-09-1751. Epub 2009 Dec 22.

PMID:
20028854
[PubMed - indexed for MEDLINE]
Free Article
5.

Invasive fungal infections in the paediatric and neonatal population: diagnostics and management issues.

Arendrup MC, Fisher BT, Zaoutis TE.

Clin Microbiol Infect. 2009 Jul;15(7):613-24. doi: 10.1111/j.1469-0691.2009.02909.x. Review.

PMID:
19673972
[PubMed - indexed for MEDLINE]
6.

Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin.

Yu K, Toral-Barza L, Shi C, Zhang WG, Lucas J, Shor B, Kim J, Verheijen J, Curran K, Malwitz DJ, Cole DC, Ellingboe J, Ayral-Kaloustian S, Mansour TS, Gibbons JJ, Abraham RT, Nowak P, Zask A.

Cancer Res. 2009 Aug 1;69(15):6232-40. doi: 10.1158/0008-5472.CAN-09-0299. Epub 2009 Jul 7.

PMID:
19584280
[PubMed - indexed for MEDLINE]
Free Article
7.

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR).

García-Martínez JM, Moran J, Clarke RG, Gray A, Cosulich SC, Chresta CM, Alessi DR.

Biochem J. 2009 Jun 12;421(1):29-42. doi: 10.1042/BJ20090489.

PMID:
19402821
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.

Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, Ruggero D, Shokat KM.

PLoS Biol. 2009 Feb 10;7(2):e38. doi: 10.1371/journal.pbio.1000038.

PMID:
19209957
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.

Thoreen CC, Kang SA, Chang JW, Liu Q, Zhang J, Gao Y, Reichling LJ, Sim T, Sabatini DM, Gray NS.

J Biol Chem. 2009 Mar 20;284(12):8023-32. doi: 10.1074/jbc.M900301200. Epub 2009 Jan 15.

PMID:
19150980
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Probing the membrane environment of the TOR kinases reveals functional interactions between TORC1, actin, and membrane trafficking in Saccharomyces cerevisiae.

Aronova S, Wedaman K, Anderson S, Yates J 3rd, Powers T.

Mol Biol Cell. 2007 Aug;18(8):2779-94. Epub 2007 May 16.

PMID:
17507646
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Mutual antagonism of target of rapamycin and calcineurin signaling.

Mulet JM, Martin DE, Loewith R, Hall MN.

J Biol Chem. 2006 Nov 3;281(44):33000-7. Epub 2006 Sep 7.

PMID:
16959779
[PubMed - indexed for MEDLINE]
Free Article
12.

TOR signaling in growth and metabolism.

Wullschleger S, Loewith R, Hall MN.

Cell. 2006 Feb 10;124(3):471-84. Review.

PMID:
16469695
[PubMed - indexed for MEDLINE]
Free Article
13.

Global analysis of protein phosphorylation in yeast.

Ptacek J, Devgan G, Michaud G, Zhu H, Zhu X, Fasolo J, Guo H, Jona G, Breitkreutz A, Sopko R, McCartney RR, Schmidt MC, Rachidi N, Lee SJ, Mah AS, Meng L, Stark MJ, Stern DF, De Virgilio C, Tyers M, Andrews B, Gerstein M, Schweitzer B, Predki PF, Snyder M.

Nature. 2005 Dec 1;438(7068):679-84.

PMID:
16319894
[PubMed - indexed for MEDLINE]
14.

DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1.

Ira G, Pellicioli A, Balijja A, Wang X, Fiorani S, Carotenuto W, Liberi G, Bressan D, Wan L, Hollingsworth NM, Haber JE, Foiani M.

Nature. 2004 Oct 21;431(7011):1011-7.

PMID:
15496928
[PubMed - indexed for MEDLINE]
15.

Discovery of cercosporamide, a known antifungal natural product, as a selective Pkc1 kinase inhibitor through high-throughput screening.

Sussman A, Huss K, Chio LC, Heidler S, Shaw M, Ma D, Zhu G, Campbell RM, Park TS, Kulanthaivel P, Scott JE, Carpenter JW, Strege MA, Belvo MD, Swartling JR, Fischl A, Yeh WK, Shih C, Ye XS.

Eukaryot Cell. 2004 Aug;3(4):932-43.

PMID:
15302826
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.

Loewith R, Jacinto E, Wullschleger S, Lorberg A, Crespo JL, Bonenfant D, Oppliger W, Jenoe P, Hall MN.

Mol Cell. 2002 Sep;10(3):457-68.

PMID:
12408816
[PubMed - indexed for MEDLINE]
Free Article
17.

The effects of transcription regulating genes PDR1, pdr1-3 and PDR3 in pleiotropic drug resistance.

Nawrocki A, Fey SJ, Goffeau A, Roepstorff P, Larsen PM.

Proteomics. 2001 Aug;1(8):1022-32. Erratum in: Proteomics 2001 Oct;1(10):1340-1.

PMID:
11683503
[PubMed - indexed for MEDLINE]
18.

Mechanism of metabolic control. Target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors.

Komeili A, Wedaman KP, O'Shea EK, Powers T.

J Cell Biol. 2000 Nov 13;151(4):863-78.

PMID:
11076970
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression.

Kunz J, Henriquez R, Schneider U, Deuter-Reinhard M, Movva NR, Hall MN.

Cell. 1993 May 7;73(3):585-96.

PMID:
8387896
[PubMed - indexed for MEDLINE]
20.

TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast.

Helliwell SB, Wagner P, Kunz J, Deuter-Reinhard M, Henriquez R, Hall MN.

Mol Biol Cell. 1994 Jan;5(1):105-18.

PMID:
8186460
[PubMed - indexed for MEDLINE]
Free PMC Article

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