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Results: 1 to 20 of 58

1.

Dictyostelium huntingtin controls chemotaxis and cytokinesis through the regulation of myosin II phosphorylation.

Wang Y, Steimle PA, Ren Y, Ross CA, Robinson DN, Egelhoff TT, Sesaki H, Iijima M.

Mol Biol Cell. 2011 Jul 1;22(13):2270-81. doi: 10.1091/mbc.E10-11-0926. Epub 2011 May 11.

PMID:
21562226
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Deficiency of huntingtin has pleiotropic effects in the social amoeba Dictyostelium discoideum.

Myre MA, Lumsden AL, Thompson MN, Wasco W, MacDonald ME, Gusella JF.

PLoS Genet. 2011 Apr;7(4):e1002052. doi: 10.1371/journal.pgen.1002052. Epub 2011 Apr 28.

PMID:
21552328
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a γ-secretase-independent manner.

Neely KM, Green KN, LaFerla FM.

J Neurosci. 2011 Feb 23;31(8):2781-91. doi: 10.1523/JNEUROSCI.5156-10.2010.

PMID:
21414900
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease.

Munsie L, Caron N, Atwal RS, Marsden I, Wild EJ, Bamburg JR, Tabrizi SJ, Truant R.

Hum Mol Genet. 2011 May 15;20(10):1937-51. doi: 10.1093/hmg/ddr075. Epub 2011 Feb 25.

PMID:
21355047
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

APP processing in Alzheimer's disease.

Zhang YW, Thompson R, Zhang H, Xu H.

Mol Brain. 2011 Jan 7;4:3. doi: 10.1186/1756-6606-4-3. Review.

PMID:
21214928
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Presenilin mouse and zebrafish models for dementia: focus on neurogenesis.

van Tijn P, Kamphuis W, Marlatt MW, Hol EM, Lucassen PJ.

Prog Neurobiol. 2011 Feb;93(2):149-64. doi: 10.1016/j.pneurobio.2010.10.008. Epub 2010 Nov 5. Review.

PMID:
21056616
[PubMed - indexed for MEDLINE]
Free Article
7.

The dynamic cytoskeleton: backbone of dendritic spine plasticity.

Dent EW, Merriam EB, Hu X.

Curr Opin Neurobiol. 2011 Feb;21(1):175-81. doi: 10.1016/j.conb.2010.08.013. Epub 2010 Sep 9. Review.

PMID:
20832290
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Dictyostelium possesses highly diverged presenilin/gamma-secretase that regulates growth and cell-fate specification and can accurately process human APP: a system for functional studies of the presenilin/gamma-secretase complex.

McMains VC, Myre M, Kreppel L, Kimmel AR.

Dis Model Mech. 2010 Sep-Oct;3(9-10):581-94. doi: 10.1242/dmm.004457. Epub 2010 Aug 10.

PMID:
20699477
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Molecular mechanisms and potential therapeutical targets in Huntington's disease.

Zuccato C, Valenza M, Cattaneo E.

Physiol Rev. 2010 Jul;90(3):905-81. doi: 10.1152/physrev.00041.2009. Review.

PMID:
20664076
[PubMed - indexed for MEDLINE]
Free Article
10.

Conserved developmental transcriptomes in evolutionarily divergent species.

Parikh A, Miranda ER, Katoh-Kurasawa M, Fuller D, Rot G, Zagar L, Curk T, Sucgang R, Chen R, Zupan B, Loomis WF, Kuspa A, Shaulsky G.

Genome Biol. 2010;11(3):R35. doi: 10.1186/gb-2010-11-3-r35. Epub 2010 Mar 17.

PMID:
20236529
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

F-actin binding regions on the androgen receptor and huntingtin increase aggregation and alter aggregate characteristics.

Angeli S, Shao J, Diamond MI.

PLoS One. 2010 Feb 4;5(2):e9053. doi: 10.1371/journal.pone.0009053.

PMID:
20140226
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Selective neuronal requirement for huntingtin in the developing zebrafish.

Henshall TL, Tucker B, Lumsden AL, Nornes S, Lardelli MT, Richards RI.

Hum Mol Genet. 2009 Dec 15;18(24):4830-42. doi: 10.1093/hmg/ddp455. Epub 2009 Sep 29.

PMID:
19797250
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Presenilin-dependent regulated intramembrane proteolysis and gamma-secretase activity.

McCarthy JV, Twomey C, Wujek P.

Cell Mol Life Sci. 2009 May;66(9):1534-55. doi: 10.1007/s00018-009-8435-9. Review.

PMID:
19189053
[PubMed - indexed for MEDLINE]
14.

Spatiotemporal regulation of Ras activity provides directional sensing.

Zhang S, Charest PG, Firtel RA.

Curr Biol. 2008 Oct 28;18(20):1587-93. doi: 10.1016/j.cub.2008.08.069.

PMID:
18948008
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Sequence analyses of presenilin mutations linked to familial Alzheimer's disease.

Kim SD, Kim J.

Cell Stress Chaperones. 2008 Dec;13(4):401-12. doi: 10.1007/s12192-008-0046-0. Epub 2008 May 20. Review.

PMID:
18491041
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Huntington's disease: from pathology and genetics to potential therapies.

Imarisio S, Carmichael J, Korolchuk V, Chen CW, Saiki S, Rose C, Krishna G, Davies JE, Ttofi E, Underwood BR, Rubinsztein DC.

Biochem J. 2008 Jun 1;412(2):191-209. doi: 10.1042/BJ20071619. Review.

PMID:
18466116
[PubMed - indexed for MEDLINE]
17.

Inositol 1,4,5-tripshosphate receptor, calcium signalling and Huntington's disease.

Bezprozvanny I.

Subcell Biochem. 2007;45:323-35. Review.

PMID:
18193642
[PubMed - indexed for MEDLINE]
18.

A cell culture model for investigation of Hirano bodies.

Davis RC, Furukawa R, Fechheimer M.

Acta Neuropathol. 2008 Feb;115(2):205-17. Epub 2007 Nov 3.

PMID:
17978823
[PubMed - indexed for MEDLINE]
19.

Huntingtin-deficient zebrafish exhibit defects in iron utilization and development.

Lumsden AL, Henshall TL, Dayan S, Lardelli MT, Richards RI.

Hum Mol Genet. 2007 Aug 15;16(16):1905-20. Epub 2007 Jun 13.

PMID:
17567778
[PubMed - indexed for MEDLINE]
Free Article
20.

Loss of huntingtin function complemented by small molecules acting as repressor element 1/neuron restrictive silencer element silencer modulators.

Rigamonti D, Bolognini D, Mutti C, Zuccato C, Tartari M, Sola F, Valenza M, Kazantsev AG, Cattaneo E.

J Biol Chem. 2007 Aug 24;282(34):24554-62. Epub 2007 Jun 12.

PMID:
17565993
[PubMed - indexed for MEDLINE]
Free Article

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