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Results: 1 to 20 of 32

1.

PARP inhibitors stumble in breast cancer.

Guha M.

Nat Biotechnol. 2011 May;29(5):373-4. doi: 10.1038/nbt0511-373. No abstract available.

PMID:
21552220
[PubMed - indexed for MEDLINE]
2.

Pathways of mammalian replication fork restart.

Petermann E, Helleday T.

Nat Rev Mol Cell Biol. 2010 Oct;11(10):683-7. doi: 10.1038/nrm2974. Epub 2010 Sep 15. Review.

PMID:
20842177
[PubMed - indexed for MEDLINE]
3.

Small molecule inhibitors of DNA repair nuclease activities of APE1.

Wilson DM 3rd, Simeonov A.

Cell Mol Life Sci. 2010 Nov;67(21):3621-31. doi: 10.1007/s00018-010-0488-2. Epub 2010 Aug 31. Review.

PMID:
20809131
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells.

Bapat A, Glass LS, Luo M, Fishel ML, Long EC, Georgiadis MM, Kelley MR.

J Pharmacol Exp Ther. 2010 Sep 1;334(3):988-98. doi: 10.1124/jpet.110.169128. Epub 2010 May 26.

PMID:
20504914
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

PARP inhibition: PARP1 and beyond.

Rouleau M, Patel A, Hendzel MJ, Kaufmann SH, Poirier GG.

Nat Rev Cancer. 2010 Apr;10(4):293-301. doi: 10.1038/nrc2812. Epub 2010 Mar 4. Review.

PMID:
20200537
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Human AP endonuclease 1 (APE1): from mechanistic insights to druggable target in cancer.

Abbotts R, Madhusudan S.

Cancer Treat Rev. 2010 Aug;36(5):425-35. doi: 10.1016/j.ctrv.2009.12.006. Epub 2010 Jan 6. Review.

PMID:
20056333
[PubMed - indexed for MEDLINE]
7.

Redox regulation of DNA repair: implications for human health and cancer therapeutic development.

Luo M, He H, Kelley MR, Georgiadis MM.

Antioxid Redox Signal. 2010 Jun 1;12(11):1247-69. doi: 10.1089/ars.2009.2698. Review.

PMID:
19764832
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1.

Simeonov A, Kulkarni A, Dorjsuren D, Jadhav A, Shen M, McNeill DR, Austin CP, Wilson DM 3rd.

PLoS One. 2009 Jun 1;4(6):e5740. doi: 10.1371/journal.pone.0005740.

PMID:
19484131
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

DNA repair in mammalian cells: Base excision repair: the long and short of it.

Robertson AB, Klungland A, Rognes T, Leiros I.

Cell Mol Life Sci. 2009 Mar;66(6):981-93. doi: 10.1007/s00018-009-8736-z. Review.

PMID:
19153658
[PubMed - indexed for MEDLINE]
10.

Pharmacophore guided discovery of small-molecule human apurinic/apyrimidinic endonuclease 1 inhibitors.

Zawahir Z, Dayam R, Deng J, Pereira C, Neamati N.

J Med Chem. 2009 Jan 8;52(1):20-32. doi: 10.1021/jm800739m.

PMID:
19072053
[PubMed - indexed for MEDLINE]
11.

The many functions of APE1/Ref-1: not only a DNA repair enzyme.

Tell G, Quadrifoglio F, Tiribelli C, Kelley MR.

Antioxid Redox Signal. 2009 Mar;11(3):601-20. doi: 10.1089/ars.2008.2194. Review.

PMID:
18976116
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Transcriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein.

Bhakat KK, Mantha AK, Mitra S.

Antioxid Redox Signal. 2009 Mar;11(3):621-38. doi: 10.1089/ARS.2008.2198. Review.

PMID:
18715144
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Going ape as an approach to cancer therapeutics.

Bapat A, Fishel ML, Kelley MR.

Antioxid Redox Signal. 2009 Mar;11(3):651-68. doi: 10.1089/ARS.2008.2218. Review.

PMID:
18715143
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Potent inhibition of human apurinic/apyrimidinic endonuclease 1 by arylstibonic acids.

Seiple LA, Cardellina JH 2nd, Akee R, Stivers JT.

Mol Pharmacol. 2008 Mar;73(3):669-77. Epub 2007 Nov 27.

PMID:
18042731
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Processing of nonconventional DNA strand break ends.

Wilson DM 3rd.

Environ Mol Mutagen. 2007 Dec;48(9):772-82. Review.

PMID:
17948279
[PubMed - indexed for MEDLINE]
16.

The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target.

Fishel ML, Kelley MR.

Mol Aspects Med. 2007 Jun-Aug;28(3-4):375-95. Epub 2007 May 3. Review.

PMID:
17560642
[PubMed - indexed for MEDLINE]
17.

Manipulation of base excision repair to sensitize ovarian cancer cells to alkylating agent temozolomide.

Fishel ML, He Y, Smith ML, Kelley MR.

Clin Cancer Res. 2007 Jan 1;13(1):260-7.

PMID:
17200364
[PubMed - indexed for MEDLINE]
Free Article
18.

Temozolomide: a milestone in neuro-oncology and beyond?

Mutter N, Stupp R.

Expert Rev Anticancer Ther. 2006 Aug;6(8):1187-204. Review.

PMID:
16925485
[PubMed - indexed for MEDLINE]
19.

Molecular and biological roles of Ape1 protein in mammalian base excision repair.

Demple B, Sung JS.

DNA Repair (Amst). 2005 Dec 8;4(12):1442-9. Epub 2005 Sep 30. Review.

PMID:
16199212
[PubMed - indexed for MEDLINE]
20.

Isolation of a small molecule inhibitor of DNA base excision repair.

Madhusudan S, Smart F, Shrimpton P, Parsons JL, Gardiner L, Houlbrook S, Talbot DC, Hammonds T, Freemont PA, Sternberg MJ, Dianov GL, Hickson ID.

Nucleic Acids Res. 2005 Aug 19;33(15):4711-24. Print 2005.

PMID:
16113242
[PubMed - indexed for MEDLINE]
Free PMC Article

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