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Items: 1 to 20 of 83

1.

Homogeneous insulin and C-Peptide sensors for rapid assessment of insulin and C-peptide secretion by the islets.

Heyduk E, Moxley MM, Salvatori A, Corbett JA, Heyduk T.

Diabetes. 2010 Oct;59(10):2360-5. doi: 10.2337/db10-0088. Epub 2010 Jul 9.

2.

Glucolipotoxicity alters lipid partitioning and causes mitochondrial dysfunction, cholesterol, and ceramide deposition and reactive oxygen species production in INS832/13 ss-cells.

El-Assaad W, Joly E, Barbeau A, Sladek R, Buteau J, Maestre I, Pepin E, Zhao S, Iglesias J, Roche E, Prentki M.

Endocrinology. 2010 Jul;151(7):3061-73. doi: 10.1210/en.2009-1238. Epub 2010 May 5.

PMID:
20444946
3.

The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins.

Rocks O, Gerauer M, Vartak N, Koch S, Huang ZP, Pechlivanis M, Kuhlmann J, Brunsveld L, Chandra A, Ellinger B, Waldmann H, Bastiaens PI.

Cell. 2010 Apr 30;141(3):458-71. doi: 10.1016/j.cell.2010.04.007. Epub 2010 Apr 22.

4.

Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes.

Igoillo-Esteve M, Marselli L, Cunha DA, Ladrière L, Ortis F, Grieco FA, Dotta F, Weir GC, Marchetti P, Eizirik DL, Cnop M.

Diabetologia. 2010 Jul;53(7):1395-405. doi: 10.1007/s00125-010-1707-y. Epub 2010 Apr 6. Erratum in: Diabetologia. 2012 Mar;55(3):863.

PMID:
20369226
5.

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease.

Hotamisligil GS.

Cell. 2010 Mar 19;140(6):900-17. doi: 10.1016/j.cell.2010.02.034. Review.

6.

Global estimates of the prevalence of diabetes for 2010 and 2030.

Shaw JE, Sicree RA, Zimmet PZ.

Diabetes Res Clin Pract. 2010 Jan;87(1):4-14. doi: 10.1016/j.diabres.2009.10.007. Epub 2009 Nov 6.

PMID:
19896746
7.

Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I.

Böni-Schnetzler M, Boller S, Debray S, Bouzakri K, Meier DT, Prazak R, Kerr-Conte J, Pattou F, Ehses JA, Schuit FC, Donath MY.

Endocrinology. 2009 Dec;150(12):5218-29. doi: 10.1210/en.2009-0543. Epub 2009 Oct 9.

PMID:
19819943
8.

Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload.

Preston AM, Gurisik E, Bartley C, Laybutt DR, Biden TJ.

Diabetologia. 2009 Nov;52(11):2369-73. doi: 10.1007/s00125-009-1506-5. Epub 2009 Aug 29.

PMID:
19727664
9.

Glucolipotoxicity of the pancreatic beta cell.

Poitout V, Amyot J, Semache M, Zarrouki B, Hagman D, Fontés G.

Biochim Biophys Acta. 2010 Mar;1801(3):289-98. doi: 10.1016/j.bbalip.2009.08.006. Epub 2009 Aug 26. Review.

10.

Analysis of DHHC acyltransferases implies overlapping substrate specificity and a two-step reaction mechanism.

Hou H, John Peter AT, Meiringer C, Subramanian K, Ungermann C.

Traffic. 2009 Aug;10(8):1061-73. doi: 10.1111/j.1600-0854.2009.00925.x. Epub 2009 May 12.

PMID:
19453970
11.

Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1.

Bachar E, Ariav Y, Ketzinel-Gilad M, Cerasi E, Kaiser N, Leibowitz G.

PLoS One. 2009;4(3):e4954. doi: 10.1371/journal.pone.0004954. Epub 2009 Mar 23.

12.

The fat controller: roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review).

Greaves J, Prescott GR, Gorleku OA, Chamberlain LH.

Mol Membr Biol. 2009 Jan;26(1):67-79. doi: 10.1080/09687680802620351. Epub 2008 Dec 29. Review.

PMID:
19115144
13.

Differential regulation of the ER stress response by long-chain fatty acids in the pancreatic beta-cell.

Diakogiannaki E, Morgan NG.

Biochem Soc Trans. 2008 Oct;36(Pt 5):959-62. doi: 10.1042/BST0360959. Review.

PMID:
18793169
14.

Neutral red uptake assay for the estimation of cell viability/cytotoxicity.

Repetto G, del Peso A, Zurita JL.

Nat Protoc. 2008;3(7):1125-31. doi: 10.1038/nprot.2008.75.

PMID:
18600217
15.

Initiation and execution of lipotoxic ER stress in pancreatic beta-cells.

Cunha DA, Hekerman P, Ladrière L, Bazarra-Castro A, Ortis F, Wakeham MC, Moore F, Rasschaert J, Cardozo AK, Bellomo E, Overbergh L, Mathieu C, Lupi R, Hai T, Herchuelz A, Marchetti P, Rutter GA, Eizirik DL, Cnop M.

J Cell Sci. 2008 Jul 15;121(Pt 14):2308-18. doi: 10.1242/jcs.026062. Epub 2008 Jun 17.

16.
17.

Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis.

Martinez SC, Tanabe K, Cras-Méneur C, Abumrad NA, Bernal-Mizrachi E, Permutt MA.

Diabetes. 2008 Apr;57(4):846-59. doi: 10.2337/db07-0595. Epub 2008 Jan 3.

18.

Glucolipotoxicity: fuel excess and beta-cell dysfunction.

Poitout V, Robertson RP.

Endocr Rev. 2008 May;29(3):351-66. Epub 2007 Nov 29. Review.

19.

Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?

Malhotra JD, Kaufman RJ.

Antioxid Redox Signal. 2007 Dec;9(12):2277-93. Review.

PMID:
17979528
20.

Peroxisome proliferator-activated receptor alpha-retinoid X receptor agonists induce beta-cell protection against palmitate toxicity.

Hellemans K, Kerckhofs K, Hannaert JC, Martens G, Van Veldhoven P, Pipeleers D.

FEBS J. 2007 Dec;274(23):6094-105. Epub 2007 Oct 26.

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