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Results: 1 to 20 of 73

1.

Atomic force microscopy and MD simulations reveal pore-like structures of all-D-enantiomer of Alzheimer's β-amyloid peptide: relevance to the ion channel mechanism of AD pathology.

Connelly L, Jang H, Arce FT, Capone R, Kotler SA, Ramachandran S, Kagan BL, Nussinov R, Lal R.

J Phys Chem B. 2012 Feb 9;116(5):1728-35. doi: 10.1021/jp2108126. Epub 2012 Jan 25.

PMID:
22217000
[PubMed - indexed for MEDLINE]
2.

Antimicrobial properties of amyloid peptides.

Kagan BL, Jang H, Capone R, Teran Arce F, Ramachandran S, Lal R, Nussinov R.

Mol Pharm. 2012 Apr 2;9(4):708-17. doi: 10.1021/mp200419b. Epub 2011 Nov 29. Review.

PMID:
22081976
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Single-channel Ca(2+) imaging implicates Aβ1-42 amyloid pores in Alzheimer's disease pathology.

Demuro A, Smith M, Parker I.

J Cell Biol. 2011 Oct 31;195(3):515-24. doi: 10.1083/jcb.201104133. Epub 2011 Oct 24.

PMID:
22024165
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Antimicrobial protegrin-1 forms amyloid-like fibrils with rapid kinetics suggesting a functional link.

Jang H, Arce FT, Mustata M, Ramachandran S, Capone R, Nussinov R, Lal R.

Biophys J. 2011 Apr 6;100(7):1775-83. doi: 10.1016/j.bpj.2011.01.072.

PMID:
21463591
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Alzheimer's disease.

Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, Jones E.

Lancet. 2011 Mar 19;377(9770):1019-31. doi: 10.1016/S0140-6736(10)61349-9. Epub 2011 Mar 1. Review.

PMID:
21371747
[PubMed - indexed for MEDLINE]
6.

Lipid matrix plays a role in Abeta fibril kinetics and morphology.

Sani MA, Gehman JD, Separovic F.

FEBS Lett. 2011 Mar 9;585(5):749-54. doi: 10.1016/j.febslet.2011.02.011. Epub 2011 Feb 12.

PMID:
21320494
[PubMed - indexed for MEDLINE]
Free Article
7.

Crystal structure of the amyloid-β p3 fragment provides a model for oligomer formation in Alzheimer's disease.

Streltsov VA, Varghese JN, Masters CL, Nuttall SD.

J Neurosci. 2011 Jan 26;31(4):1419-26. doi: 10.1523/JNEUROSCI.4259-10.2011.

PMID:
21273426
[PubMed - indexed for MEDLINE]
Free Article
8.

β-Barrel topology of Alzheimer's β-amyloid ion channels.

Jang H, Arce FT, Ramachandran S, Capone R, Lal R, Nussinov R.

J Mol Biol. 2010 Dec 17;404(5):917-34. doi: 10.1016/j.jmb.2010.10.025. Epub 2010 Oct 21.

PMID:
20970427
[PubMed - indexed for MEDLINE]
9.

Models of membrane-bound Alzheimer's Abeta peptide assemblies.

Shafrir Y, Durell S, Arispe N, Guy HR.

Proteins. 2010 Dec;78(16):3473-87. doi: 10.1002/prot.22853. Epub 2010 Oct 11.

PMID:
20939098
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

DHPC strongly affects the structure and oligomerization propensity of Alzheimer's Aβ(1-40) peptide.

Dahse K, Garvey M, Kovermann M, Vogel A, Balbach J, Fändrich M, Fahr A.

J Mol Biol. 2010 Nov 5;403(4):643-59. doi: 10.1016/j.jmb.2010.09.021. Epub 2010 Sep 17.

PMID:
20851128
[PubMed - indexed for MEDLINE]
11.

Amyloid peptide pores and the beta sheet conformation.

Kagan BL, Thundimadathil J.

Adv Exp Med Biol. 2010;677:150-67. Review.

PMID:
20687488
[PubMed - indexed for MEDLINE]
12.

Structural convergence among diverse, toxic beta-sheet ion channels.

Jang H, Teran Arce F, Ramachandran S, Capone R, Lal R, Nussinov R.

J Phys Chem B. 2010 Jul 29;114(29):9445-51. doi: 10.1021/jp104073k.

PMID:
20608696
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

A molecular dynamics study of the early stages of amyloid-beta(1-42) oligomerization: the role of lipid membranes.

Davis CH, Berkowitz ML.

Proteins. 2010 Aug 15;78(11):2533-45. doi: 10.1002/prot.22763.

PMID:
20602359
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Antimicrobial protegrin-1 forms ion channels: molecular dynamic simulation, atomic force microscopy, and electrical conductance studies.

Capone R, Mustata M, Jang H, Arce FT, Nussinov R, Lal R.

Biophys J. 2010 Jun 2;98(11):2644-52. doi: 10.1016/j.bpj.2010.02.024.

PMID:
20513409
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Truncated beta-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome.

Jang H, Arce FT, Ramachandran S, Capone R, Azimova R, Kagan BL, Nussinov R, Lal R.

Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6538-43. doi: 10.1073/pnas.0914251107. Epub 2010 Mar 22.

PMID:
20308552
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide.

Soscia SJ, Kirby JE, Washicosky KJ, Tucker SM, Ingelsson M, Hyman B, Burton MA, Goldstein LE, Duong S, Tanzi RE, Moir RD.

PLoS One. 2010 Mar 3;5(3):e9505. doi: 10.1371/journal.pone.0009505.

PMID:
20209079
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Misfolded amyloid ion channels present mobile beta-sheet subunits in contrast to conventional ion channels.

Jang H, Arce FT, Capone R, Ramachandran S, Lal R, Nussinov R.

Biophys J. 2009 Dec 2;97(11):3029-37. doi: 10.1016/j.bpj.2009.09.014.

PMID:
19948133
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

K3 fragment of amyloidogenic beta(2)-microglobulin forms ion channels: implication for dialysis related amyloidosis.

Mustata M, Capone R, Jang H, Arce FT, Ramachandran S, Lal R, Nussinov R.

J Am Chem Soc. 2009 Oct 21;131(41):14938-45. doi: 10.1021/ja9049299.

PMID:
19824733
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Hexokinase II detachment from the mitochondria potentiates cisplatin induced cytotoxicity through a caspase-2 dependent mechanism.

Shulga N, Wilson-Smith R, Pastorino JG.

Cell Cycle. 2009 Oct 15;8(20):3355-64. Epub 2009 Oct 19.

PMID:
19770592
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Amyloid-beta-induced ion flux in artificial lipid bilayers and neuronal cells: resolving a controversy.

Capone R, Quiroz FG, Prangkio P, Saluja I, Sauer AM, Bautista MR, Turner RS, Yang J, Mayer M.

Neurotox Res. 2009 Jul;16(1):1-13. doi: 10.1007/s12640-009-9033-1. Epub 2009 Mar 19.

PMID:
19526294
[PubMed - indexed for MEDLINE]
Free PMC Article

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