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Items: 1 to 20 of 46

1.

Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver.

Li Y, Xu S, Giles A, Nakamura K, Lee JW, Hou X, Donmez G, Li J, Luo Z, Walsh K, Guarente L, Zang M.

FASEB J. 2011 May;25(5):1664-79. doi: 10.1096/fj.10-173492. Epub 2011 Feb 14.

2.

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.

Herranz D, Muñoz-Martin M, Cañamero M, Mulero F, Martinez-Pastor B, Fernandez-Capetillo O, Serrano M.

Nat Commun. 2010 Apr 12;1:3. doi: 10.1038/ncomms1001.

3.

SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator.

Dai H, Kustigian L, Carney D, Case A, Considine T, Hubbard BP, Perni RB, Riera TV, Szczepankiewicz B, Vlasuk GP, Stein RL.

J Biol Chem. 2010 Oct 22;285(43):32695-703. doi: 10.1074/jbc.M110.133892. Epub 2010 Aug 11.

4.

Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.

Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM.

Genes Dev. 2010 Jul 1;24(13):1403-17. doi: 10.1101/gad.1901210.

5.

A high-throughput respirometric assay for mitochondrial biogenesis and toxicity.

Beeson CC, Beeson GC, Schnellmann RG.

Anal Biochem. 2010 Sep 1;404(1):75-81. doi: 10.1016/j.ab.2010.04.040. Epub 2010 May 11.

6.

Sirt1 activation protects the mouse renal medulla from oxidative injury.

He W, Wang Y, Zhang MZ, You L, Davis LS, Fan H, Yang HC, Fogo AB, Zent R, Harris RC, Breyer MD, Hao CM.

J Clin Invest. 2010 Apr;120(4):1056-68. doi: 10.1172/JCI41563. Epub 2010 Mar 24.

7.

SRT1720 induces mitochondrial biogenesis and rescues mitochondrial function after oxidant injury in renal proximal tubule cells.

Funk JA, Odejinmi S, Schnellmann RG.

J Pharmacol Exp Ther. 2010 May;333(2):593-601. doi: 10.1124/jpet.109.161992. Epub 2010 Jan 26.

8.

Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice.

Escande C, Chini CC, Nin V, Dykhouse KM, Novak CM, Levine J, van Deursen J, Gores GJ, Chen J, Lou Z, Chini EN.

J Clin Invest. 2010 Feb;120(2):545-58. doi: 10.1172/JCI39319. Epub 2010 Jan 11.

9.

SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1.

Pacholec M, Bleasdale JE, Chrunyk B, Cunningham D, Flynn D, Garofalo RS, Griffith D, Griffor M, Loulakis P, Pabst B, Qiu X, Stockman B, Thanabal V, Varghese A, Ward J, Withka J, Ahn K.

J Biol Chem. 2010 Mar 12;285(11):8340-51. doi: 10.1074/jbc.M109.088682. Epub 2010 Jan 8.

10.

SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity.

Yoshizaki T, Schenk S, Imamura T, Babendure JL, Sonoda N, Bae EJ, Oh DY, Lu M, Milne JC, Westphal C, Bandyopadhyay G, Olefsky JM.

Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E419-28. doi: 10.1152/ajpendo.00417.2009. Epub 2009 Dec 8.

11.

Resveratrol is not a direct activator of SIRT1 enzyme activity.

Beher D, Wu J, Cumine S, Kim KW, Lu SC, Atangan L, Wang M.

Chem Biol Drug Des. 2009 Dec;74(6):619-24. doi: 10.1111/j.1747-0285.2009.00901.x. Epub 2009 Oct 20.

PMID:
19843076
12.

Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice.

Yamazaki Y, Usui I, Kanatani Y, Matsuya Y, Tsuneyama K, Fujisaka S, Bukhari A, Suzuki H, Senda S, Imanishi S, Hirata K, Ishiki M, Hayashi R, Urakaze M, Nemoto H, Kobayashi M, Tobe K.

Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E1179-86. doi: 10.1152/ajpendo.90997.2008. Epub 2009 Sep 1.

13.

Gene expression profiling of aging in multiple mouse strains: identification of aging biomarkers and impact of dietary antioxidants.

Park SK, Kim K, Page GP, Allison DB, Weindruch R, Prolla TA.

Aging Cell. 2009 Aug;8(4):484-95. doi: 10.1111/j.1474-9726.2009.00496.x. Epub 2009 Jun 25.

14.

PGC-1{alpha} and PGC-1{beta} regulate mitochondrial density in neurons.

Wareski P, Vaarmann A, Choubey V, Safiulina D, Liiv J, Kuum M, Kaasik A.

J Biol Chem. 2009 Aug 7;284(32):21379-85. doi: 10.1074/jbc.M109.018911. Epub 2009 Jun 19.

15.

Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo.

Smith JJ, Kenney RD, Gagne DJ, Frushour BP, Ladd W, Galonek HL, Israelian K, Song J, Razvadauskaite G, Lynch AV, Carney DP, Johnson RJ, Lavu S, Iffland A, Elliott PJ, Lambert PD, Elliston KO, Jirousek MR, Milne JC, Boss O.

BMC Syst Biol. 2009 Mar 10;3:31. doi: 10.1186/1752-0509-3-31.

16.

SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes.

Yoshizaki T, Milne JC, Imamura T, Schenk S, Sonoda N, Babendure JL, Lu JC, Smith JJ, Jirousek MR, Olefsky JM.

Mol Cell Biol. 2009 Mar;29(5):1363-74. doi: 10.1128/MCB.00705-08. Epub 2008 Dec 22.

17.

Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation.

Feige JN, Lagouge M, Canto C, Strehle A, Houten SM, Milne JC, Lambert PD, Mataki C, Elliott PJ, Auwerx J.

Cell Metab. 2008 Nov;8(5):347-58. doi: 10.1016/j.cmet.2008.08.017. Erratum in: Cell Metab. 2009 Feb;9(2):210.

18.

The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha}.

Coste A, Louet JF, Lagouge M, Lerin C, Antal MC, Meziane H, Schoonjans K, Puigserver P, O'Malley BW, Auwerx J.

Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17187-92. doi: 10.1073/pnas.0808207105. Epub 2008 Oct 28.

19.

A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange.

Liu Y, Dentin R, Chen D, Hedrick S, Ravnskjaer K, Schenk S, Milne J, Meyers DJ, Cole P, Yates J 3rd, Olefsky J, Guarente L, Montminy M.

Nature. 2008 Nov 13;456(7219):269-73. doi: 10.1038/nature07349. Epub 2008 Oct 5.

20.

SirT1 gain of function increases energy efficiency and prevents diabetes in mice.

Banks AS, Kon N, Knight C, Matsumoto M, Gutiérrez-Juárez R, Rossetti L, Gu W, Accili D.

Cell Metab. 2008 Oct;8(4):333-41. doi: 10.1016/j.cmet.2008.08.014.

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