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Results: 1 to 20 of 35

1.

Emerging mechanisms of disrupted cellular signaling in brain ischemia.

Tymianski M.

Nat Neurosci. 2011 Oct 26;14(11):1369-73. doi: 10.1038/nn.2951.

PMID:
22030547
[PubMed - indexed for MEDLINE]
2.

Perturbing PSD-95 interactions with NR2B-subtype receptors attenuates spinal nociceptive plasticity and neuropathic pain.

D'Mello R, Marchand F, Pezet S, McMahon SB, Dickenson AH.

Mol Ther. 2011 Oct;19(10):1780-92. doi: 10.1038/mt.2011.42. Epub 2011 Mar 22.

PMID:
21427709
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Cell-permeable and plasma-stable peptidomimetic inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction.

Bach A, Eildal JN, Stuhr-Hansen N, Deeskamp R, Gottschalk M, Pedersen SW, Kristensen AS, Strømgaard K.

J Med Chem. 2011 Mar 10;54(5):1333-46. doi: 10.1021/jm1013924. Epub 2011 Feb 15.

PMID:
21322614
[PubMed - indexed for MEDLINE]
4.

Biomimetic divalent ligands for the acute disruption of synaptic AMPAR stabilization.

Sainlos M, Tigaret C, Poujol C, Olivier NB, Bard L, Breillat C, Thiolon K, Choquet D, Imperiali B.

Nat Chem Biol. 2011 Feb;7(2):81-91. doi: 10.1038/nchembio.498. Epub 2010 Dec 26.

PMID:
21186349
[PubMed - indexed for MEDLINE]
5.

Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models.

Ittner LM, Ke YD, Delerue F, Bi M, Gladbach A, van Eersel J, Wölfing H, Chieng BC, Christie MJ, Napier IA, Eckert A, Staufenbiel M, Hardeman E, Götz J.

Cell. 2010 Aug 6;142(3):387-97. doi: 10.1016/j.cell.2010.06.036. Epub 2010 Jul 22.

PMID:
20655099
[PubMed - indexed for MEDLINE]
Free Article
6.

Deciphering the kinetic binding mechanism of dimeric ligands using a potent plasma-stable dimeric inhibitor of postsynaptic density protein-95 as an example.

Chi CN, Bach A, Gottschalk M, Kristensen AS, Strømgaard K, Jemth P.

J Biol Chem. 2010 Sep 3;285(36):28252-60. doi: 10.1074/jbc.M110.124040. Epub 2010 Jun 24.

PMID:
20576616
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

A cyclic peptide targeted against PSD-95 blocks central sensitization and attenuates thermal hyperalgesia.

LeBlanc BW, Iwata M, Mallon AP, Rupasinghe CN, Goebel DJ, Marshall J, Spaller MR, Saab CY.

Neuroscience. 2010 May 5;167(2):490-500. doi: 10.1016/j.neuroscience.2010.02.031. Epub 2010 Feb 16.

PMID:
20167266
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95-NMDA receptor interaction.

Bach A, Chi CN, Pang GF, Olsen L, Kristensen AS, Jemth P, Strømgaard K.

Angew Chem Int Ed Engl. 2009;48(51):9685-9. doi: 10.1002/anie.200904741. No abstract available.

PMID:
19937879
[PubMed - indexed for MEDLINE]
9.

Microglia protect neurons against ischemia by synthesis of tumor necrosis factor.

Lambertsen KL, Clausen BH, Babcock AA, Gregersen R, Fenger C, Nielsen HH, Haugaard LS, Wirenfeldt M, Nielsen M, Dagnaes-Hansen F, Bluethmann H, Faergeman NJ, Meldgaard M, Deierborg T, Finsen B.

J Neurosci. 2009 Feb 4;29(5):1319-30. doi: 10.1523/JNEUROSCI.5505-08.2009.

PMID:
19193879
[PubMed - indexed for MEDLINE]
Free Article
10.

Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density.

Feng W, Zhang M.

Nat Rev Neurosci. 2009 Feb;10(2):87-99. doi: 10.1038/nrn2540. Review.

PMID:
19153575
[PubMed - indexed for MEDLINE]
11.

Creating conformational entropy by increasing interdomain mobility in ligand binding regulation: a revisit to N-terminal tandem PDZ domains of PSD-95.

Wang W, Weng J, Zhang X, Liu M, Zhang M.

J Am Chem Soc. 2009 Jan 21;131(2):787-96. doi: 10.1021/ja8076022.

PMID:
19072119
[PubMed - indexed for MEDLINE]
12.

Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand.

Soriano FX, Martel MA, Papadia S, Vaslin A, Baxter P, Rickman C, Forder J, Tymianski M, Duncan R, Aarts M, Clarke P, Wyllie DJ, Hardingham GE.

J Neurosci. 2008 Oct 15;28(42):10696-710. doi: 10.1523/JNEUROSCI.1207-08.2008.

PMID:
18923045
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction.

Bach A, Chi CN, Olsen TB, Pedersen SW, Røder MU, Pang GF, Clausen RP, Jemth P, Strømgaard K.

J Med Chem. 2008 Oct 23;51(20):6450-9. doi: 10.1021/jm800836w. Epub 2008 Sep 24.

PMID:
18811137
[PubMed - indexed for MEDLINE]
14.

Small molecule protein-protein interaction inhibitors as CNS therapeutic agents: current progress and future hurdles.

Blazer LL, Neubig RR.

Neuropsychopharmacology. 2009 Jan;34(1):126-41. doi: 10.1038/npp.2008.151. Epub 2008 Sep 17. Review.

PMID:
18800065
[PubMed - indexed for MEDLINE]
Free Article
15.

Cell-permeable peptide Tat-PSD-95 PDZ2 inhibits chronic inflammatory pain behaviors in mice.

Tao F, Su Q, Johns RA.

Mol Ther. 2008 Nov;16(11):1776-82. doi: 10.1038/mt.2008.192. Epub 2008 Sep 9.

PMID:
18781143
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Effectiveness of PSD95 inhibitors in permanent and transient focal ischemia in the rat.

Sun HS, Doucette TA, Liu Y, Fang Y, Teves L, Aarts M, Ryan CL, Bernard PB, Lau A, Forder JP, Salter MW, Wang YT, Tasker RA, Tymianski M.

Stroke. 2008 Sep;39(9):2544-53. doi: 10.1161/STROKEAHA.107.506048. Epub 2008 Jul 10.

PMID:
18617669
[PubMed - indexed for MEDLINE]
Free Article
17.

MAGUK proteins: new targets for pharmacological intervention in the glutamatergic synapse.

Gardoni F.

Eur J Pharmacol. 2008 May 6;585(1):147-52. doi: 10.1016/j.ejphar.2008.01.048. Epub 2008 Feb 26. Review.

PMID:
18367167
[PubMed - indexed for MEDLINE]
18.

Neuroprotection for ischemic stroke: past, present and future.

Ginsberg MD.

Neuropharmacology. 2008 Sep;55(3):363-89. doi: 10.1016/j.neuropharm.2007.12.007. Epub 2008 Mar 4. Review.

PMID:
18308347
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Unbiased cell quantification reveals a continued increase in the number of neocortical neurones during early post-natal development in mice.

Lyck L, Krøigård T, Finsen B.

Eur J Neurosci. 2007 Oct;26(7):1749-64.

PMID:
17897392
[PubMed - indexed for MEDLINE]
20.

Bivalent peptides as models for multimeric targets of PDZ domains.

Paduch M, Biernat M, Stefanowicz P, Derewenda ZS, Szewczuk Z, Otlewski J.

Chembiochem. 2007 Mar 5;8(4):443-52.

PMID:
17279591
[PubMed - indexed for MEDLINE]

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