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Items: 1 to 20 of 78


Switching Cdk2 on or off with small molecules to reveal requirements in human cell proliferation.

Merrick KA, Wohlbold L, Zhang C, Allen JJ, Horiuchi D, Huskey NE, Goga A, Shokat KM, Fisher RP.

Mol Cell. 2011 Jun 10;42(5):624-36. doi: 10.1016/j.molcel.2011.03.031.


The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2.

Zeng X, Shaikh FY, Harrison MK, Adon AM, Trimboli AJ, Carroll KA, Sharma N, Timmers C, Chodosh LA, Leone G, Saavedra HI.

Oncogene. 2010 Sep 9;29(36):5103-12. doi: 10.1038/onc.2010.253. Epub 2010 Jun 28.


Mitotic chromosomal instability and cancer: mouse modelling of the human disease.

Schvartzman JM, Sotillo R, Benezra R.

Nat Rev Cancer. 2010 Feb;10(2):102-15. doi: 10.1038/nrc2781. Review.


Simple, realistic models of complex biological processes: positive feedback and bistability in a cell fate switch and a cell cycle oscillator.

Ferrell JE Jr, Pomerening JR, Kim SY, Trunnell NB, Xiong W, Huang CY, Machleder EM.

FEBS Lett. 2009 Dec 17;583(24):3999-4005. doi: 10.1016/j.febslet.2009.10.068. Epub . Review.


Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells.

Kalaszczynska I, Geng Y, Iino T, Mizuno S, Choi Y, Kondratiuk I, Silver DP, Wolgemuth DJ, Akashi K, Sicinski P.

Cell. 2009 Jul 23;138(2):352-65. doi: 10.1016/j.cell.2009.04.062. Epub 2009 Jul 9.


Response of small intestinal epithelial cells to acute disruption of cell division through CDC25 deletion.

Lee G, White LS, Hurov KE, Stappenbeck TS, Piwnica-Worms H.

Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4701-6. doi: 10.1073/pnas.0900751106. Epub 2009 Mar 9.


Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2.

Reinhardt HC, Yaffe MB.

Curr Opin Cell Biol. 2009 Apr;21(2):245-55. doi: 10.1016/ Epub 2009 Feb 21. Review.


In vivo roles of CDC25 phosphatases: biological insight into the anti-cancer therapeutic targets.

Kiyokawa H, Ray D.

Anticancer Agents Med Chem. 2008 Dec;8(8):832-6. Review.


Dual regulation of Cdc25A by Chk1 and p53-ATF3 in DNA replication checkpoint control.

Demidova AR, Aau MY, Zhuang L, Yu Q.

J Biol Chem. 2009 Feb 13;284(7):4132-9. doi: 10.1074/jbc.M808118200. Epub 2008 Dec 7.


Cdc25A serine 123 phosphorylation couples centrosome duplication with DNA replication and regulates tumorigenesis.

Shreeram S, Hee WK, Bulavin DV.

Mol Cell Biol. 2008 Dec;28(24):7442-50. doi: 10.1128/MCB.00138-08. Epub 2008 Oct 20.


Control of the reversibility of cellular quiescence by the transcriptional repressor HES1.

Sang L, Coller HA, Roberts JM.

Science. 2008 Aug 22;321(5892):1095-100. doi: 10.1126/science.1155998.


Oncogenes and tumour suppressors take on centrosomes.

Fukasawa K.

Nat Rev Cancer. 2007 Dec;7(12):911-24. Review.


Cdk1 is sufficient to drive the mammalian cell cycle.

Santamaría D, Barrière C, Cerqueira A, Hunt S, Tardy C, Newton K, Cáceres JF, Dubus P, Malumbres M, Barbacid M.

Nature. 2007 Aug 16;448(7155):811-5.


CDC25 phosphatases in cancer cells: key players? Good targets?

Boutros R, Lobjois V, Ducommun B.

Nat Rev Cancer. 2007 Jul;7(7):495-507. Review.


Deregulated CDC25A expression promotes mammary tumorigenesis with genomic instability.

Ray D, Terao Y, Fuhrken PG, Ma ZQ, DeMayo FJ, Christov K, Heerema NA, Franks R, Tsai SY, Papoutsakis ET, Kiyokawa H.

Cancer Res. 2007 Feb 1;67(3):984-91.


p53 downregulates expression of the G1/S cell cycle phosphatase Cdc25A.

Rother K, Kirschner R, Sänger K, Böhlig L, Mössner J, Engeland K.

Oncogene. 2007 Mar 22;26(13):1949-53. Epub 2006 Sep 25.


A new description of cellular quiescence.

Coller HA, Sang L, Roberts JM.

PLoS Biol. 2006 Mar;4(3):e83. Epub 2006 Mar 7.


The when and wheres of CDC25 phosphatases.

Boutros R, Dozier C, Ducommun B.

Curr Opin Cell Biol. 2006 Apr;18(2):185-91. Epub 2006 Feb 17. Review.


A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression.

Besson A, Gurian-West M, Chen X, Kelly-Spratt KS, Kemp CJ, Roberts JM.

Genes Dev. 2006 Jan 1;20(1):47-64.


Cdc25B cooperates with Cdc25A to induce mitosis but has a unique role in activating cyclin B1-Cdk1 at the centrosome.

Lindqvist A, Källström H, Lundgren A, Barsoum E, Rosenthal CK.

J Cell Biol. 2005 Oct 10;171(1):35-45.

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