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Items: 1 to 20 of 34


Surgical stress resistance induced by single amino acid deprivation requires Gcn2 in mice.

Peng W, Robertson L, Gallinetti J, Mejia P, Vose S, Charlip A, Chu T, Mitchell JR.

Sci Transl Med. 2012 Jan 25;4(118):118ra11. doi: 10.1126/scitranslmed.3002629.


Amino acid signaling in TOR activation.

Kim J, Guan KL.

Annu Rev Biochem. 2011;80:1001-32. doi: 10.1146/annurev-biochem-062209-094414. Review.


Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients.

Lee C, Longo VD.

Oncogene. 2011 Jul 28;30(30):3305-16. doi: 10.1038/onc.2011.91. Epub 2011 Apr 25. Review.


Hallmarks of cancer: the next generation.

Hanahan D, Weinberg RA.

Cell. 2011 Mar 4;144(5):646-74. doi: 10.1016/j.cell.2011.02.013. Review.


Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation.

Fabrizio P, Hoon S, Shamalnasab M, Galbani A, Wei M, Giaever G, Nislow C, Longo VD.

PLoS Genet. 2010 Jul 15;6(7):e1001024. doi: 10.1371/journal.pgen.1001024.


Extending healthy life span--from yeast to humans.

Fontana L, Partridge L, Longo VD.

Science. 2010 Apr 16;328(5976):321-6. doi: 10.1126/science.1172539. Review.


Fasting and cancer treatment in humans: A case series report.

Safdie FM, Dorff T, Quinn D, Fontana L, Wei M, Lee C, Cohen P, Longo VD.

Aging (Albany NY). 2009 Dec 31;1(12):988-1007.


Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index.

Lee C, Safdie FM, Raffaghello L, Wei M, Madia F, Parrella E, Hwang D, Cohen P, Bianchi G, Longo VD.

Cancer Res. 2010 Feb 15;70(4):1564-72. doi: 10.1158/0008-5472.CAN-09-3228. Epub 2010 Feb 9.


Calorie restriction and cancer prevention: metabolic and molecular mechanisms.

Longo VD, Fontana L.

Trends Pharmacol Sci. 2010 Feb;31(2):89-98. doi: 10.1016/ Epub 2010 Jan 25. Review.


Short-term dietary restriction and fasting precondition against ischemia reperfusion injury in mice.

Mitchell JR, Verweij M, Brand K, van de Ven M, Goemaere N, van den Engel S, Chu T, Forrer F, Müller C, de Jong M, van IJcken W, IJzermans JN, Hoeijmakers JH, de Bruin RW.

Aging Cell. 2010 Feb;9(1):40-53. doi: 10.1111/j.1474-9726.2009.00532.x. Epub 2009 Oct 30.


Tumours with PI3K activation are resistant to dietary restriction.

Kalaany NY, Sabatini DM.

Nature. 2009 Apr 9;458(7239):725-31. doi: 10.1038/nature07782. Epub 2009 Mar 11.


Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis.

Nogueira V, Park Y, Chen CC, Xu PZ, Chen ML, Tonic I, Unterman T, Hay N.

Cancer Cell. 2008 Dec 9;14(6):458-70. doi: 10.1016/j.ccr.2008.11.003.


Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans.

Fontana L, Weiss EP, Villareal DT, Klein S, Holloszy JO.

Aging Cell. 2008 Oct;7(5):681-7.


SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons.

Li Y, Xu W, McBurney MW, Longo VD.

Cell Metab. 2008 Jul;8(1):38-48. doi: 10.1016/j.cmet.2008.05.004.


Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy.

Raffaghello L, Lee C, Safdie FM, Wei M, Madia F, Bianchi G, Longo VD.

Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8215-20. doi: 10.1073/pnas.0708100105. Epub 2008 Mar 31.


Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular aging.

Ungvari Z, Parrado-Fernandez C, Csiszar A, de Cabo R.

Circ Res. 2008 Mar 14;102(5):519-28. doi: 10.1161/CIRCRESAHA.107.168369. Review.


Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9.

Wei M, Fabrizio P, Hu J, Ge H, Cheng C, Li L, Longo VD.

PLoS Genet. 2008 Jan;4(1):e13. doi: 10.1371/journal.pgen.0040013. Epub 2007 Dec 13.


Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP.

Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50. Epub 2005 Sep 30.


PAGE: parametric analysis of gene set enrichment.

Kim SY, Volsky DJ.

BMC Bioinformatics. 2005 Jun 8;6:144.


Toward a unified theory of caloric restriction and longevity regulation.

Sinclair DA.

Mech Ageing Dev. 2005 Sep;126(9):987-1002. Review.

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