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Items: 1 to 20 of 56

1.

Complex-disease networks of trait-associated single-nucleotide polymorphisms (SNPs) unveiled by information theory.

Li H, Lee Y, Chen JL, Rebman E, Li J, Lussier YA.

J Am Med Inform Assoc. 2012 Mar-Apr;19(2):295-305. doi: 10.1136/amiajnl-2011-000482. Epub 2012 Jan 25.

2.

A vector space model approach to identify genetically related diseases.

Sarkar IN.

J Am Med Inform Assoc. 2012 Mar-Apr;19(2):249-54. doi: 10.1136/amiajnl-2011-000480. Epub 2012 Jan 6.

3.

Discovery and preclinical validation of drug indications using compendia of public gene expression data.

Sirota M, Dudley JT, Kim J, Chiang AP, Morgan AA, Sweet-Cordero A, Sage J, Butte AJ.

Sci Transl Med. 2011 Aug 17;3(96):96ra77. doi: 10.1126/scitranslmed.3001318. Erratum in: Sci Transl Med. 2011 Sep 28;3(102):102er7.

4.

The emergence of genome-based drug repositioning.

Lussier YA, Chen JL.

Sci Transl Med. 2011 Aug 17;3(96):96ps35. doi: 10.1126/scitranslmed.3001512.

5.

Protein-network modeling of prostate cancer gene signatures reveals essential pathways in disease recurrence.

Chen JL, Li J, Stadler WM, Lussier YA.

J Am Med Inform Assoc. 2011 Jul-Aug;18(4):392-402. doi: 10.1136/amiajnl-2011-000178.

6.

PREDICT: a method for inferring novel drug indications with application to personalized medicine.

Gottlieb A, Stein GY, Ruppin E, Sharan R.

Mol Syst Biol. 2011 Jun 7;7:496. doi: 10.1038/msb.2011.26.

7.

Integrated genome-scale prediction of detrimental mutations in transcription networks.

Francesconi M, Jelier R, Lehner B.

PLoS Genet. 2011 May;7(5):e1002077. doi: 10.1371/journal.pgen.1002077. Epub 2011 May 26.

8.

SVA: software for annotating and visualizing sequenced human genomes.

Ge D, Ruzzo EK, Shianna KV, He M, Pelak K, Heinzen EL, Need AC, Cirulli ET, Maia JM, Dickson SP, Zhu M, Singh A, Allen AS, Goldstein DB.

Bioinformatics. 2011 Jul 15;27(14):1998-2000. doi: 10.1093/bioinformatics/btr317. Epub 2011 May 29.

9.

Alzheimer's disease: the challenge of the second century.

Holtzman DM, Morris JC, Goate AM.

Sci Transl Med. 2011 Apr 6;3(77):77sr1. doi: 10.1126/scitranslmed.3002369. Review.

10.

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, Evans D, Schneider JA, Carrasquillo MM, Ertekin-Taner N, Younkin SG, Cruchaga C, Kauwe JS, Nowotny P, Kramer P, Hardy J, Huentelman MJ, Myers AJ, Barmada MM, Demirci FY, Baldwin CT, Green RC, Rogaeva E, St George-Hyslop P, Arnold SE, Barber R, Beach T, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Cummings JL, DeCarli C, DeKosky ST, Diaz-Arrastia R, Dick M, Dickson DW, Ellis WG, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Johnson N, Karlawish J, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Lah JJ, Levey AI, Lieberman AP, Lopez OL, Mack WJ, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Parisi JE, Perl DP, Peskind E, Petersen RC, Poon WW, Quinn JF, Rajbhandary RA, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosenberg RN, Sano M, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Cantwell LB, Dombroski BA, Beekly D, Lunetta KL, Martin ER, Kamboh MI, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD.

Nat Genet. 2011 May;43(5):436-41. doi: 10.1038/ng.801. Epub 2011 Apr 3.

11.

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.

Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, Abraham R, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Jones N, Stretton A, Thomas C, Richards A, Ivanov D, Widdowson C, Chapman J, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Beaumont H, Warden D, Wilcock G, Love S, Kehoe PG, Hooper NM, Vardy ER, Hardy J, Mead S, Fox NC, Rossor M, Collinge J, Maier W, Jessen F, Rüther E, Schürmann B, Heun R, Kölsch H, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Gallacher J, Hüll M, Rujescu D, Giegling I, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn PP, Van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Pankratz VS, Sando SB, Aasly JO, Barcikowska M, Wszolek ZK, Dickson DW, Graff-Radford NR, Petersen RC; Alzheimer's Disease Neuroimaging Initiative, van Duijn CM, Breteler MM, Ikram MA, DeStefano AL, Fitzpatrick AL, Lopez O, Launer LJ, Seshadri S; CHARGE consortium, Berr C, Campion D, Epelbaum J, Dartigues JF, Tzourio C, Alpérovitch A, Lathrop M; EADI1 consortium, Feulner TM, Friedrich P, Riehle C, Krawczak M, Schreiber S, Mayhaus M, Nicolhaus S, Wagenpfeil S, Steinberg S, Stefansson H, Stefansson K, Snaedal J, Björnsson S, Jonsson PV, Chouraki V, Genier-Boley B, Hiltunen M, Soininen H, Combarros O, Zelenika D, Delepine M, Bullido MJ, Pasquier F, Mateo I, Frank-Garcia A, Porcellini E, Hanon O, Coto E, Alvarez V, Bosco P, Siciliano G, Mancuso M, Panza F, Solfrizzi V, Nacmias B, Sorbi S, Bossù P, Piccardi P, Arosio B, Annoni G, Seripa D, Pilotto A, Scarpini E, Galimberti D, Brice A, Hannequin D, Licastro F, Jones L, Holmans PA, Jonsson T, Riemenschneider M, Morgan K, Younkin SG, Owen MJ, O'Donovan M, Amouyel P, Williams J.

Nat Genet. 2011 May;43(5):429-35. doi: 10.1038/ng.803. Epub 2011 Apr 3.

12.

GO-Module: functional synthesis and improved interpretation of Gene Ontology patterns.

Yang X, Li J, Lee Y, Lussier YA.

Bioinformatics. 2011 May 15;27(10):1444-6. doi: 10.1093/bioinformatics/btr142. Epub 2011 Mar 17.

13.

Biomolecular Systems of Disease Buried Across Multiple GWAS Unveiled by Information Theory and Ontology.

Lee Y, Li J, Gamazon E, Chen JL, Tikhomirov A, Cox NJ, Lussier YA.

AMIA Jt Summits Transl Sci Proc. 2010 Mar 1;2010:31-5.

14.

Mining gold dust under the genome wide significance level: a two-stage approach to analysis of GWAS.

Shi G, Boerwinkle E, Morrison AC, Gu CC, Chakravarti A, Rao DC.

Genet Epidemiol. 2011 Feb;35(2):111-8. doi: 10.1002/gepi.20556. Epub 2010 Dec 31.

15.

Network medicine: a network-based approach to human disease.

Barabási AL, Gulbahce N, Loscalzo J.

Nat Rev Genet. 2011 Jan;12(1):56-68. doi: 10.1038/nrg2918. Review.

16.

Towards integrative gene prioritization in Alzheimer's disease.

Lee JH, Gonzalez GH.

Pac Symp Biocomput. 2011:4-13.

17.

DMDM: domain mapping of disease mutations.

Peterson TA, Adadey A, Santana-Cruz I, Sun Y, Winder A, Kann MG.

Bioinformatics. 2010 Oct 1;26(19):2458-9. doi: 10.1093/bioinformatics/btq447. Epub 2010 Aug 4.

18.

Clinical assessment incorporating a personal genome.

Ashley EA, Butte AJ, Wheeler MT, Chen R, Klein TE, Dewey FE, Dudley JT, Ormond KE, Pavlovic A, Morgan AA, Pushkarev D, Neff NF, Hudgins L, Gong L, Hodges LM, Berlin DS, Thorn CF, Sangkuhl K, Hebert JM, Woon M, Sagreiya H, Whaley R, Knowles JW, Chou MF, Thakuria JV, Rosenbaum AM, Zaranek AW, Church GM, Greely HT, Quake SR, Altman RB.

Lancet. 2010 May 1;375(9725):1525-35. doi: 10.1016/S0140-6736(10)60452-7.

19.

Network modeling identifies molecular functions targeted by miR-204 to suppress head and neck tumor metastasis.

Lee Y, Yang X, Huang Y, Fan H, Zhang Q, Wu Y, Li J, Hasina R, Cheng C, Lingen MW, Gerstein MB, Weichselbaum RR, Xing HR, Lussier YA.

PLoS Comput Biol. 2010 Apr 1;6(4):e1000730. doi: 10.1371/journal.pcbi.1000730.

20.

Protein interaction network underpins concordant prognosis among heterogeneous breast cancer signatures.

Chen J, Sam L, Huang Y, Lee Y, Li J, Liu Y, Xing HR, Lussier YA.

J Biomed Inform. 2010 Jun;43(3):385-96. doi: 10.1016/j.jbi.2010.03.009. Epub 2010 Mar 27.

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