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Results: 1 to 20 of 44

1.

Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development.

Ueda T, Sasaki M, Elia AJ, Chio II, Hamada K, Fukunaga R, Mak TW.

Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):13984-90. doi: 10.1073/pnas.1008136107. Epub 2010 Aug 2.

PMID:
20679220
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression.

Furic L, Rong L, Larsson O, Koumakpayi IH, Yoshida K, Brueschke A, Petroulakis E, Robichaud N, Pollak M, Gaboury LA, Pandolfi PP, Saad F, Sonenberg N.

Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14134-9. doi: 10.1073/pnas.1005320107. Epub 2010 Aug 2.

PMID:
20679199
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs.

Dowling RJ, Topisirovic I, Alain T, Bidinosti M, Fonseca BD, Petroulakis E, Wang X, Larsson O, Selvaraj A, Liu Y, Kozma SC, Thomas G, Sonenberg N.

Science. 2010 May 28;328(5982):1172-6. doi: 10.1126/science.1187532.

PMID:
20508131
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

A comparison between Skp2 and FOXO1 for their cytoplasmic localization by Akt1.

Wang H, Cui J, Bauzon F, Zhu L.

Cell Cycle. 2010 Mar 1;9(5):1021-2. Epub 2010 Mar 9. No abstract available.

PMID:
20160512
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Phosphorylation of Ser72 does not regulate the ubiquitin ligase activity and subcellular localization of Skp2.

Boutonnet C, Tanguay PL, Julien C, Rodier G, Coulombe P, Meloche S.

Cell Cycle. 2010 Mar 1;9(5):975-9. Epub 2010 Mar 9.

PMID:
20160482
[PubMed - indexed for MEDLINE]
Free Article
6.

Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization.

Bashir T, Pagan JK, Busino L, Pagano M.

Cell Cycle. 2010 Mar 1;9(5):971-4. Epub 2010 Mar 9.

PMID:
20160477
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

p53-dependent translational control of senescence and transformation via 4E-BPs.

Petroulakis E, Parsyan A, Dowling RJ, LeBacquer O, Martineau Y, Bidinosti M, Larsson O, Alain T, Rong L, Mamane Y, Paquet M, Furic L, Topisirovic I, Shahbazian D, Livingstone M, Costa-Mattioli M, Teodoro JG, Sonenberg N.

Cancer Cell. 2009 Nov 6;16(5):439-46. doi: 10.1016/j.ccr.2009.09.025.

PMID:
19878875
[PubMed - indexed for MEDLINE]
Free Article
8.

mTOR signaling at a glance.

Laplante M, Sabatini DM.

J Cell Sci. 2009 Oct 15;122(Pt 20):3589-94. doi: 10.1242/jcs.051011. Review. No abstract available.

PMID:
19812304
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

mTORC1 hyperactivity inhibits serum deprivation-induced apoptosis via increased hexokinase II and GLUT1 expression, sustained Mcl-1 expression, and glycogen synthase kinase 3beta inhibition.

Bhaskar PT, Nogueira V, Patra KC, Jeon SM, Park Y, Robey RB, Hay N.

Mol Cell Biol. 2009 Sep;29(18):5136-47. doi: 10.1128/MCB.01946-08. Epub 2009 Jul 20.

PMID:
19620286
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway.

Zhang HH, Huang J, Düvel K, Boback B, Wu S, Squillace RM, Wu CL, Manning BD.

PLoS One. 2009 Jul 10;4(7):e6189. doi: 10.1371/journal.pone.0006189.

PMID:
19593385
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction.

Gao D, Inuzuka H, Tseng A, Chin RY, Toker A, Wei W.

Nat Cell Biol. 2009 Apr;11(4):397-408. doi: 10.1038/ncb1847. Epub 2009 Mar 8.

PMID:
19270695
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB.

Lin HK, Wang G, Chen Z, Teruya-Feldstein J, Liu Y, Chan CH, Yang WL, Erdjument-Bromage H, Nakayama KI, Nimer S, Tempst P, Pandolfi PP.

Nat Cell Biol. 2009 Apr;11(4):420-32. doi: 10.1038/ncb1849. Epub 2009 Mar 8.

PMID:
19270694
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis.

Robey RB, Hay N.

Semin Cancer Biol. 2009 Feb;19(1):25-31. doi: 10.1016/j.semcancer.2008.11.010. Epub 2008 Dec 14. Review.

PMID:
19130886
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis.

Nogueira V, Park Y, Chen CC, Xu PZ, Chen ML, Tonic I, Unterman T, Hay N.

Cancer Cell. 2008 Dec 9;14(6):458-70. doi: 10.1016/j.ccr.2008.11.003.

PMID:
19061837
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer.

Frescas D, Pagano M.

Nat Rev Cancer. 2008 Jun;8(6):438-49. doi: 10.1038/nrc2396. Review.

PMID:
18500245
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy.

Ramírez-Valle F, Braunstein S, Zavadil J, Formenti SC, Schneider RJ.

J Cell Biol. 2008 Apr 21;181(2):293-307. doi: 10.1083/jcb.200710215.

PMID:
18426977
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

The F box protein S phase kinase-associated protein 2 regulates adipose mass and adipocyte number in vivo.

Cooke PS, Holsberger DR, Cimafranca MA, Meling DD, Beals CM, Nakayama K, Nakayama KI, Kiyokawa H.

Obesity (Silver Spring). 2007 Jun;15(6):1400-8.

PMID:
17557977
[PubMed - indexed for MEDLINE]
18.

The two TORCs and Akt.

Bhaskar PT, Hay N.

Dev Cell. 2007 Apr;12(4):487-502. Review.

PMID:
17419990
[PubMed - indexed for MEDLINE]
Free Article
19.

Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2.

Le Bacquer O, Petroulakis E, Paglialunga S, Poulin F, Richard D, Cianflone K, Sonenberg N.

J Clin Invest. 2007 Feb;117(2):387-96.

PMID:
17273556
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Adipocyte differentiation from the inside out.

Rosen ED, MacDougald OA.

Nat Rev Mol Cell Biol. 2006 Dec;7(12):885-96. Review.

PMID:
17139329
[PubMed - indexed for MEDLINE]
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