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Results: 1 to 20 of 60

References for PMC Articles for PubMed (Select 22267986)

1.

Synthesis and Structure-Activity Relationships of Benzothienothiazepinone Inhibitors of Protein Kinase D.

Bravo-Altamirano K, George KM, Frantz MC, Lavalle CR, Tandon M, Leimgruber S, Sharlow ER, Lazo JS, Wang QJ, Wipf P.

ACS Med Chem Lett. 2011 Feb 14;2(2):154-159.

2.

3,5-diarylazoles as novel and selective inhibitors of protein kinase D.

Gamber GG, Meredith E, Zhu Q, Yan W, Rao C, Capparelli M, Burgis R, Enyedy I, Zhang JH, Soldermann N, Beattie K, Rozhitskaya O, Koch KA, Pagratis N, Hosagrahara V, Vega RB, McKinsey TA, Monovich L.

Bioorg Med Chem Lett. 2011 Mar 1;21(5):1447-51. doi: 10.1016/j.bmcl.2011.01.014. Epub 2011 Jan 11.

PMID:
21300545
3.

Identification of potent and selective amidobipyridyl inhibitors of protein kinase D.

Meredith EL, Beattie K, Burgis R, Capparelli M, Chapo J, Dipietro L, Gamber G, Enyedy I, Hood DB, Hosagrahara V, Jewell C, Koch KA, Lee W, Lemon DD, McKinsey TA, Miranda K, Pagratis N, Phan D, Plato C, Rao C, Rozhitskaya O, Soldermann N, Springer C, van Eis M, Vega RB, Yan W, Zhu Q, Monovich LG.

J Med Chem. 2010 Aug 12;53(15):5422-38. doi: 10.1021/jm100076w.

PMID:
20684592
4.

Identification of orally available naphthyridine protein kinase D inhibitors.

Meredith EL, Ardayfio O, Beattie K, Dobler MR, Enyedy I, Gaul C, Hosagrahara V, Jewell C, Koch K, Lee W, Lehmann H, McKinsey TA, Miranda K, Pagratis N, Pancost M, Patnaik A, Phan D, Plato C, Qian M, Rajaraman V, Rao C, Rozhitskaya O, Ruppen T, Shi J, Siska SJ, Springer C, van Eis M, Vega RB, von Matt A, Yang L, Yoon T, Zhang JH, Zhu N, Monovich LG.

J Med Chem. 2010 Aug 12;53(15):5400-21. doi: 10.1021/jm100075z.

PMID:
20684591
5.

Protein kinase D as a potential new target for cancer therapy.

LaValle CR, George KM, Sharlow ER, Lazo JS, Wipf P, Wang QJ.

Biochim Biophys Acta. 2010 Dec;1806(2):183-92. doi: 10.1016/j.bbcan.2010.05.003. Epub 2010 May 24. Review.

6.

Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility.

Lavalle CR, Bravo-Altamirano K, Giridhar KV, Chen J, Sharlow E, Lazo JS, Wipf P, Wang QJ.

BMC Chem Biol. 2010 May 5;10:5. doi: 10.1186/1472-6769-10-5.

7.

A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo.

Harikumar KB, Kunnumakkara AB, Ochi N, Tong Z, Deorukhkar A, Sung B, Kelland L, Jamieson S, Sutherland R, Raynham T, Charles M, Bagherzadeh A, Foxton C, Boakes A, Farooq M, Maru D, Diagaradjane P, Matsuo Y, Sinnett-Smith J, Gelovani J, Krishnan S, Aggarwal BB, Rozengurt E, Ireson CR, Guha S.

Mol Cancer Ther. 2010 May;9(5):1136-46. doi: 10.1158/1535-7163.MCT-09-1145. Epub 2010 May 4. Erratum in: Mol Cancer Ther. 2010 Jul;9(7):2153. Bagherazadeh, Azadeh [corrected to Bagherzadeh, Azadeh].

8.

A novel kinase inhibitor establishes a predominant role for protein kinase D as a cardiac class IIa histone deacetylase kinase.

Monovich L, Vega RB, Meredith E, Miranda K, Rao C, Capparelli M, Lemon DD, Phan D, Koch KA, Chapo JA, Hood DB, McKinsey TA.

FEBS Lett. 2010 Feb 5;584(3):631-7. doi: 10.1016/j.febslet.2009.12.014. Epub 2009 Dec 14.

9.

CID755673 enhances mitogenic signaling by phorbol esters, bombesin and EGF through a protein kinase D-independent pathway.

Torres-Marquez E, Sinnett-Smith J, Guha S, Kui R, Waldron RT, Rey O, Rozengurt E.

Biochem Biophys Res Commun. 2010 Jan 1;391(1):63-8. doi: 10.1016/j.bbrc.2009.11.002. Epub 2009 Nov 5.

10.

Protein kinase D1, a new molecular player in VEGF signaling and angiogenesis.

Ha CH, Jin ZG.

Mol Cells. 2009 Jul 31;28(1):1-5. doi: 10.1007/s10059-009-0109-9. Epub 2009 Jul 20. Review.

11.

Protein kinase D mediates mitogenic signaling by Gq-coupled receptors through protein kinase C-independent regulation of activation loop Ser744 and Ser748 phosphorylation.

Sinnett-Smith J, Jacamo R, Kui R, Wang YM, Young SH, Rey O, Waldron RT, Rozengurt E.

J Biol Chem. 2009 May 15;284(20):13434-45. doi: 10.1074/jbc.M806554200. Epub 2009 Mar 16.

12.

Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion.

Eiseler T, Döppler H, Yan IK, Goodison S, Storz P.

Breast Cancer Res. 2009;11(1):R13. doi: 10.1186/bcr2232. Epub 2009 Feb 25.

13.

p38delta and PKD1: kinase switches for insulin secretion.

Cuenda A, Nebreda AR.

Cell. 2009 Jan 23;136(2):209-10. doi: 10.1016/j.cell.2009.01.005.

14.

Regio- and chemoselective synthesis of fully substituted thiophenes.

Piller FM, Knochel P.

Org Lett. 2009 Jan 15;11(2):445-8. doi: 10.1021/ol802513q.

PMID:
19099513
15.

Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinolone.

Sharlow ER, Giridhar KV, LaValle CR, Chen J, Leimgruber S, Barrett R, Bravo-Altamirano K, Wipf P, Lazo JS, Wang QJ.

J Biol Chem. 2008 Nov 28;283(48):33516-26. doi: 10.1074/jbc.M805358200. Epub 2008 Sep 30.

16.

A new kid on the block: PKD1: a promising target for antiangiogenic therapy?

Altschmied J, Haendeler J.

Arterioscler Thromb Vasc Biol. 2008 Oct;28(10):1689-90. doi: 10.1161/ATVBAHA.108.174250. No abstract available.

17.

VEGF stimulates HDAC7 phosphorylation and cytoplasmic accumulation modulating matrix metalloproteinase expression and angiogenesis.

Ha CH, Jhun BS, Kao HY, Jin ZG.

Arterioscler Thromb Vasc Biol. 2008 Oct;28(10):1782-8. doi: 10.1161/ATVBAHA.108.172528. Epub 2008 Jul 10.

18.

Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7.

Wang S, Li X, Parra M, Verdin E, Bassel-Duby R, Olson EN.

Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7738-43. doi: 10.1073/pnas.0802857105. Epub 2008 May 28.

19.

Protein kinase D3 (PKD3) contributes to prostate cancer cell growth and survival through a PKCepsilon/PKD3 pathway downstream of Akt and ERK 1/2.

Chen J, Deng F, Singh SV, Wang QJ.

Cancer Res. 2008 May 15;68(10):3844-53. doi: 10.1158/0008-5472.CAN-07-5156.

20.

Sequential protein kinase C (PKC)-dependent and PKC-independent protein kinase D catalytic activation via Gq-coupled receptors: differential regulation of activation loop Ser(744) and Ser(748) phosphorylation.

Jacamo R, Sinnett-Smith J, Rey O, Waldron RT, Rozengurt E.

J Biol Chem. 2008 May 9;283(19):12877-87. doi: 10.1074/jbc.M800442200. Epub 2008 Mar 12.

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