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Accelerating the development of 21st-century toxicology: outcome of a Human Toxicology Project Consortium workshop.

Stephens ML, Barrow C, Andersen ME, Boekelheide K, Carmichael PL, Holsapple MP, Lafranconi M.

Toxicol Sci. 2012 Feb;125(2):327-34. doi: 10.1093/toxsci/kfr248. Epub 2011 Sep 26.


Current and future use of genomics data in toxicology: opportunities and challenges for regulatory applications.

Goetz AK, Singh BP, Battalora M, Breier JM, Bailey JP, Chukwudebe AC, Janus ER.

Regul Toxicol Pharmacol. 2011 Nov;61(2):141-53. doi: 10.1016/j.yrtph.2011.07.012. Epub 2011 Aug 5.


EU framework 6 project: predictive toxicology (PredTox)--overview and outcome.

Suter L, Schroeder S, Meyer K, Gautier JC, Amberg A, Wendt M, Gmuender H, Mally A, Boitier E, Ellinger-Ziegelbauer H, Matheis K, Pfannkuch F.

Toxicol Appl Pharmacol. 2011 Apr 15;252(2):73-84. doi: 10.1016/j.taap.2010.10.008. Epub 2010 Oct 16.


A framework for assessing causality and adverse effects in humans with a case study of sulfur dioxide.

Goodman JE, Dodge DG, Bailey LA.

Regul Toxicol Pharmacol. 2010 Nov;58(2):308-22. doi: 10.1016/j.yrtph.2010.07.002. Epub 2010 Jul 11.


The vision of toxicity testing in the 21st century: moving from discussion to action.

Andersen ME, Krewski D.

Toxicol Sci. 2010 Sep;117(1):17-24. doi: 10.1093/toxsci/kfq188. Epub 2010 Jun 23. Review.


What role for biologically based dose-response models in estimating low-dose risk?

Crump KS, Chen C, Chiu WA, Louis TA, Portier CJ, Subramaniam RP, White PD.

Environ Health Perspect. 2010 May;118(5):585-8. doi: 10.1289/ehp.0901249. Epub 2010 Jan 4. Review.


Toxicity testing in the 21st century: using the new toxicity testing paradigm to create a taxonomy of adverse effects.

Boekelheide K, Campion SN.

Toxicol Sci. 2010 Mar;114(1):20-4. doi: 10.1093/toxsci/kfp307. Epub 2009 Dec 21.


Acetaminophen dosing of humans results in blood transcriptome and metabolome changes consistent with impaired oxidative phosphorylation.

Fannin RD, Russo M, O'Connell TM, Gerrish K, Winnike JH, Macdonald J, Newton J, Malik S, Sieber SO, Parker J, Shah R, Zhou T, Watkins PB, Paules RS.

Hepatology. 2010 Jan;51(1):227-36. doi: 10.1002/hep.23330.


Toxicity testing in the 21st century: a view from the chemical industry.

Bus JS, Becker RA.

Toxicol Sci. 2009 Dec;112(2):297-302. doi: 10.1093/toxsci/kfp234. Epub 2009 Oct 4. No abstract available.


Endless possibilities: stem cells and the vision for toxicology testing in the 21st century.

Chapin RE, Stedman DB.

Toxicol Sci. 2009 Nov;112(1):17-22. doi: 10.1093/toxsci/kfp202. Epub 2009 Aug 24.


TOX 21: new dimensions of toxicity testing.

Schmidt CW.

Environ Health Perspect. 2009 Aug;117(8):A348-53. No abstract available.


Biologically relevant exposure science for 21st century toxicity testing.

Hubal EA.

Toxicol Sci. 2009 Oct;111(2):226-32. doi: 10.1093/toxsci/kfp159. Epub 2009 Jul 14.


Cellular stress response pathway system as a sentinel ensemble in toxicological screening.

Simmons SO, Fan CY, Ramabhadran R.

Toxicol Sci. 2009 Oct;111(2):202-25. doi: 10.1093/toxsci/kfp140. Epub 2009 Jun 30. Review.


A 21st century paradigm for evaluating the health hazards of nanoscale materials?

Walker NJ, Bucher JR.

Toxicol Sci. 2009 Aug;110(2):251-4. doi: 10.1093/toxsci/kfp106. Epub 2009 May 25.


Toxicity testing in the 21st century: a view from the pharmaceutical industry.

MacDonald JS, Robertson RT.

Toxicol Sci. 2009 Jul;110(1):40-6. doi: 10.1093/toxsci/kfp088. Epub 2009 May 12. No abstract available.


A toxicology for the 21st century--mapping the road ahead.

Hartung T.

Toxicol Sci. 2009 May;109(1):18-23. doi: 10.1093/toxsci/kfp059. Epub 2009 Apr 8.


Pragmatic challenges for the vision of toxicity testing in the 21st century in a regulatory context: another Ames test? ...or a new edition of "the Red Book"?

Meek B, Doull J.

Toxicol Sci. 2009 Mar;108(1):19-21. doi: 10.1093/toxsci/kfp008. Epub 2009 Jan 23. No abstract available.


Toxicity testing in the 21st century: bringing the vision to life.

Andersen ME, Krewski D.

Toxicol Sci. 2009 Feb;107(2):324-30. doi: 10.1093/toxsci/kfn255. Epub 2008 Dec 12. Review.


Blood gene expression signatures predict exposure levels.

Bushel PR, Heinloth AN, Li J, Huang L, Chou JW, Boorman GA, Malarkey DE, Houle CD, Ward SM, Wilson RE, Fannin RD, Russo MW, Watkins PB, Tennant RW, Paules RS.

Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18211-6. Epub 2007 Nov 2.

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