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Items: 1 to 20 of 37


The oligomeric state of the truncated mechanosensitive channel of large conductance shows no variance in vivo.

Iscla I, Wray R, Blount P.

Protein Sci. 2011 Sep;20(9):1638-42. doi: 10.1002/pro.686. Epub 2011 Jul 19.


S. aureus MscL is a pentamer in vivo but of variable stoichiometries in vitro: implications for detergent-solubilized membrane proteins.

Dorwart MR, Wray R, Brautigam CA, Jiang Y, Blount P.

PLoS Biol. 2010 Dec 7;8(12):e1000555. doi: 10.1371/journal.pbio.1000555.


Manipulating the permeation of charged compounds through the MscL nanovalve.

Yang LM, Blount P.

FASEB J. 2011 Jan;25(1):428-34. doi: 10.1096/fj.10-170076. Epub 2010 Oct 7.


Structure of a tetrameric MscL in an expanded intermediate state.

Liu Z, Gandhi CS, Rees DC.

Nature. 2009 Sep 3;461(7260):120-4. doi: 10.1038/nature08277. Epub 2009 Aug 23.


An open-pore structure of the mechanosensitive channel MscL derived by determining transmembrane domain interactions upon gating.

Li Y, Wray R, Eaton C, Blount P.

FASEB J. 2009 Jul;23(7):2197-204. doi: 10.1096/fj.09-129296. Epub 2009 Mar 4.


On the structure of the N-terminal domain of the MscL channel: helical bundle or membrane interface.

Iscla I, Wray R, Blount P.

Biophys J. 2008 Sep;95(5):2283-91. doi: 10.1529/biophysj.107.127423. Epub 2008 May 30.


Gating-associated conformational changes in the mechanosensitive channel MscL.

Yoshimura K, Usukura J, Sokabe M.

Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):4033-8. doi: 10.1073/pnas.0709436105. Epub 2008 Feb 29.


Voltage-induced gating of the mechanosensitive MscL ion channel reconstituted in a tethered lipid bilayer membrane.

Andersson M, Okeyo G, Wilson D, Keizer H, Moe P, Blount P, Fine D, Dodabalapur A, Duran RS.

Biosens Bioelectron. 2008 Jan 18;23(6):919-23. Epub 2007 Oct 3.


Formation of tethered bilayer lipid membranes on gold surfaces: QCM-Z and AFM study.

Dorvel BR, Keizer HM, Fine D, Vuorinen J, Dodabalapur A, Duran RS.

Langmuir. 2007 Jun 19;23(13):7344-55. Epub 2007 May 16.


Mechanosensitive channel gating transitions resolved by functional changes upon pore modification.

Bartlett JL, Li Y, Blount P.

Biophys J. 2006 Nov 15;91(10):3684-91. Epub 2006 Aug 25.


Rationally designed chemical modulators convert a bacterial channel protein into a pH-sensory valve.

Koçer A, Walko M, Bulten E, Halza E, Feringa BL, Meijberg W.

Angew Chem Int Ed Engl. 2006 May 5;45(19):3126-30. No abstract available.


A light-actuated nanovalve derived from a channel protein.

Koçer A, Walko M, Meijberg W, Feringa BL.

Science. 2005 Jul 29;309(5735):755-8.


Cell-free synthesis of a functional ion channel in the absence of a membrane and in the presence of detergent.

Berrier C, Park KH, Abes S, Bibonne A, Betton JM, Ghazi A.

Biochemistry. 2004 Oct 5;43(39):12585-91.


Defining the physical gate of a mechanosensitive channel, MscL, by engineering metal-binding sites.

Iscla I, Levin G, Wray R, Reynolds R, Blount P.

Biophys J. 2004 Nov;87(5):3172-80. Epub 2004 Aug 31.


An in vivo assay identifies changes in residue accessibility on mechanosensitive channel gating.

Bartlett JL, Levin G, Blount P.

Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10161-5. Epub 2004 Jun 28.


Total chemical synthesis and electrophysiological characterization of mechanosensitive channels from Escherichia coli and Mycobacterium tuberculosis.

Clayton D, Shapovalov G, Maurer JA, Dougherty DA, Lester HA, Kochendoerfer GG.

Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4764-9. Epub 2004 Mar 23.


On the conformation of the COOH-terminal domain of the large mechanosensitive channel MscL.

Anishkin A, Gendel V, Sharifi NA, Chiang CS, Shirinian L, Guy HR, Sukharev S.

J Gen Physiol. 2003 Mar;121(3):227-44.


Open channel structure of MscL and the gating mechanism of mechanosensitive channels.

Perozo E, Cortes DM, Sompornpisut P, Kloda A, Martinac B.

Nature. 2002 Aug 29;418(6901):942-8.

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