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Resolving controversies on the path to Alzheimer's therapeutics.

Selkoe DJ.

Nat Med. 2011 Sep 7;17(9):1060-5. doi: 10.1038/nm.2460. Erratum in: Nat Med. 2011 Nov;17(11):1521. Nat Med. 2011 Dec;17(12):1693.


Structure, mechanism and inhibition of gamma-secretase and presenilin-like proteases.

Wolfe MS.

Biol Chem. 2010 Aug;391(8):839-47. doi: 10.1515/BC.2010.086. Review.


Aberrant amyloid precursor protein (APP) processing in hereditary forms of Alzheimer disease caused by APP familial Alzheimer disease mutations can be rescued by mutations in the APP GxxxG motif.

Munter LM, Botev A, Richter L, Hildebrand PW, Althoff V, Weise C, Kaden D, Multhaup G.

J Biol Chem. 2010 Jul 9;285(28):21636-43. doi: 10.1074/jbc.M109.088005. Epub 2010 May 7.


Update 1 of: Proteases universally recognize beta strands in their active sites.

Madala PK, Tyndall JD, Nall T, Fairlie DP.

Chem Rev. 2010 Jun 9;110(6):PR1-31. doi: 10.1021/cr900368a. Epub 2010 Apr 8. Review. No abstract available.


Sequence-specific intramembrane proteolysis: identification of a recognition motif in rhomboid substrates.

Strisovsky K, Sharpe HJ, Freeman M.

Mol Cell. 2009 Dec 25;36(6):1048-59. doi: 10.1016/j.molcel.2009.11.006.


Induced dimerization of the amyloid precursor protein leads to decreased amyloid-beta protein production.

Eggert S, Midthune B, Cottrell B, Koo EH.

J Biol Chem. 2009 Oct 16;284(42):28943-52. doi: 10.1074/jbc.M109.038646. Epub 2009 Jul 13.


Intramembrane-cleaving proteases.

Wolfe MS.

J Biol Chem. 2009 May 22;284(21):13969-73. doi: 10.1074/jbc.R800039200. Epub 2009 Feb 3. Review. No abstract available.


Intramembrane proteolysis by signal peptide peptidases: a comparative discussion of GXGD-type aspartyl proteases.

Fluhrer R, Steiner H, Haass C.

J Biol Chem. 2009 May 22;284(21):13975-9. doi: 10.1074/jbc.R800040200. Epub 2009 Feb 3. Review.


Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis.

Martin L, Fluhrer R, Haass C.

J Biol Chem. 2009 Feb 27;284(9):5662-70. doi: 10.1074/jbc.M807485200. Epub 2008 Dec 29.


Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements.

Hemming ML, Elias JE, Gygi SP, Selkoe DJ.

PLoS Biol. 2008 Oct 21;6(10):e257. doi: 10.1371/journal.pbio.0060257.


Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation.

Fluhrer R, Fukumori A, Martin L, Grammer G, Haug-Kröper M, Klier B, Winkler E, Kremmer E, Condron MM, Teplow DB, Steiner H, Haass C.

J Biol Chem. 2008 Oct 31;283(44):30121-8. doi: 10.1074/jbc.M806092200. Epub 2008 Sep 3.


Intramembrane proteolysis by gamma-secretase.

Steiner H, Fluhrer R, Haass C.

J Biol Chem. 2008 Oct 31;283(44):29627-31. doi: 10.1074/jbc.R800010200. Epub 2008 Jul 23. Review.


The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase.

Sato C, Takagi S, Tomita T, Iwatsubo T.

J Neurosci. 2008 Jun 11;28(24):6264-71. doi: 10.1523/JNEUROSCI.1163-08.2008.


Transmembrane domain 9 of presenilin determines the dynamic conformation of the catalytic site of gamma-secretase.

Tolia A, Horré K, De Strooper B.

J Biol Chem. 2008 Jul 11;283(28):19793-803. doi: 10.1074/jbc.M802461200. Epub 2008 May 15.


Homophilic interactions of the amyloid precursor protein (APP) ectodomain are regulated by the loop region and affect beta-secretase cleavage of APP.

Kaden D, Munter LM, Joshi M, Treiber C, Weise C, Bethge T, Voigt P, Schaefer M, Beyermann M, Reif B, Multhaup G.

J Biol Chem. 2008 Mar 14;283(11):7271-9. doi: 10.1074/jbc.M708046200. Epub 2008 Jan 8.


Cutting proteins within lipid bilayers: rhomboid structure and mechanism.

Lemberg MK, Freeman M.

Mol Cell. 2007 Dec 28;28(6):930-40. Review.


Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b.

Martin L, Fluhrer R, Reiss K, Kremmer E, Saftig P, Haass C.

J Biol Chem. 2008 Jan 18;283(3):1644-52. Epub 2007 Oct 25.


Amyloid beta-protein precursor juxtamembrane domain regulates specificity of gamma-secretase-dependent cleavages.

Ren Z, Schenk D, Basi GS, Shapiro IP.

J Biol Chem. 2007 Nov 30;282(48):35350-60. Epub 2007 Sep 21.


GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.

Munter LM, Voigt P, Harmeier A, Kaden D, Gottschalk KE, Weise C, Pipkorn R, Schaefer M, Langosch D, Multhaup G.

EMBO J. 2007 Mar 21;26(6):1702-12. Epub 2007 Mar 1.

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