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Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymes.

Patton GC, Stenmark P, Gollapalli DR, Sevastik R, Kursula P, Flodin S, Schuler H, Swales CT, Eklund H, Himo F, Nordlund P, Hedstrom L.

Nat Chem Biol. 2011 Oct 30;7(12):950-8. doi: 10.1038/nchembio.693.


The antibiotic potential of prokaryotic IMP dehydrogenase inhibitors.

Hedstrom L, Liechti G, Goldberg JB, Gollapalli DR.

Curr Med Chem. 2011;18(13):1909-18. Review.


Adenosine deaminase from Streptomyces coelicolor: recombinant expression, purification and characterization.

Pornbanlualap S, Chalopagorn P.

Protein Expr Purif. 2011 Aug;78(2):167-73. doi: 10.1016/j.pep.2011.04.003. Epub 2011 Apr 12.


New implications on genomic adaptation derived from the Helicobacter pylori genome comparison.

Lara-Ramírez EE, Segura-Cabrera A, Guo X, Yu G, García-Pérez CA, Rodríguez-Pérez MA.

PLoS One. 2011 Feb 28;6(2):e17300. doi: 10.1371/journal.pone.0017300. Erratum in: PLoS One. 2011;6(3). doi: 10.1371/annotation/d8fae120-5f86-4df7-8e53-46afa9c01be0. PLoS One. 2011;6(3). doi: 10.1371/annotation/2f2953da-1918-4068-a730-46660d43e6b5.


Helicobacter pylori genome evolution during human infection.

Kennemann L, Didelot X, Aebischer T, Kuhn S, Drescher B, Droege M, Reinhardt R, Correa P, Meyer TF, Josenhans C, Falush D, Suerbaum S.

Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5033-8. doi: 10.1073/pnas.1018444108. Epub 2011 Mar 7.


Recombinant Escherichia coli GMP reductase: kinetic, catalytic and chemical mechanisms, and thermodynamics of enzyme-ligand binary complex formation.

Martinelli LK, Ducati RG, Rosado LA, Breda A, Selbach BP, Santos DS, Basso LA.

Mol Biosyst. 2011 Apr;7(4):1289-305. doi: 10.1039/c0mb00245c. Epub 2011 Feb 7.


Role of purine biosynthesis in Bacillus anthracis pathogenesis and virulence.

Jenkins A, Cote C, Twenhafel N, Merkel T, Bozue J, Welkos S.

Infect Immun. 2011 Jan;79(1):153-66. doi: 10.1128/IAI.00925-10. Epub 2010 Nov 1.


Structural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases.

Gollapalli DR, Macpherson IS, Liechti G, Gorla SK, Goldberg JB, Hedstrom L.

Chem Biol. 2010 Oct 29;17(10):1084-91. doi: 10.1016/j.chembiol.2010.07.014.


Functional and structural aspects of Helicobacter pylori acidic stress response factors.

Zanotti G, Cendron L.

IUBMB Life. 2010 Oct;62(10):715-23. doi: 10.1002/iub.382. Review.


Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis.

Chekeni FB, Elliott MR, Sandilos JK, Walk SF, Kinchen JM, Lazarowski ER, Armstrong AJ, Penuela S, Laird DW, Salvesen GS, Isakson BE, Bayliss DA, Ravichandran KS.

Nature. 2010 Oct 14;467(7317):863-7. doi: 10.1038/nature09413.


Crystal structures of glycinamide ribonucleotide synthetase, PurD, from thermophilic eubacteria.

Sampei G, Baba S, Kanagawa M, Yanai H, Ishii T, Kawai H, Fukai Y, Ebihara A, Nakagawa N, Kawai G.

J Biochem. 2010 Oct;148(4):429-38. doi: 10.1093/jb/mvq088. Epub 2010 Aug 16.


Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: a target for anti-malarial chemotherapy.

Keough DT, Hocková D, Krecmerová M, Cesnek M, Holý A, Naesens L, Brereton IM, Winzor DJ, de Jersey J, Guddat LW.

Mol Biochem Parasitol. 2010 Oct;173(2):165-9. doi: 10.1016/j.molbiopara.2010.05.018. Epub 2010 Jun 1.


The primary transcriptome of the major human pathogen Helicobacter pylori.

Sharma CM, Hoffmann S, Darfeuille F, Reignier J, Findeiss S, Sittka A, Chabas S, Reiche K, Hackermüller J, Reinhardt R, Stadler PF, Vogel J.

Nature. 2010 Mar 11;464(7286):250-5. doi: 10.1038/nature08756. Epub 2010 Feb 17.


A Yersinia pestis guaBA mutant is attenuated in virulence and provides protection against plague in a mouse model of infection.

Oyston PC, Mellado-Sanchez G, Pasetti MF, Nataro JP, Titball RW, Atkins HS.

Microb Pathog. 2010 May;48(5):191-5. doi: 10.1016/j.micpath.2010.01.005. Epub 2010 Jan 22.


Helicobacter pylori typing as a tool for tracking human migration.

Yamaoka Y.

Clin Microbiol Infect. 2009 Sep;15(9):829-34. doi: 10.1111/j.1469-0691.2009.02967.x. Review.


GuaA and GuaB are essential for Borrelia burgdorferi survival in the tick-mouse infection cycle.

Jewett MW, Lawrence KA, Bestor A, Byram R, Gherardini F, Rosa PA.

J Bacteriol. 2009 Oct;191(20):6231-41. doi: 10.1128/JB.00450-09. Epub 2009 Aug 7.


Downregulation of the Escherichia coli guaB promoter by upstream-bound cyclic AMP receptor protein.

Husnain SI, Busby SJ, Thomas MS.

J Bacteriol. 2009 Oct;191(19):6094-104. doi: 10.1128/JB.00672-09. Epub 2009 Jul 24.


Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics.

Keough DT, Hocková D, Holý A, Naesens LM, Skinner-Adams TS, Jersey Jd, Guddat LW.

J Med Chem. 2009 Jul 23;52(14):4391-9. doi: 10.1021/jm900267n.


IMP dehydrogenase: structure, mechanism, and inhibition.

Hedstrom L.

Chem Rev. 2009 Jul;109(7):2903-28. doi: 10.1021/cr900021w. Review. No abstract available.


Borrelia burgdorferi bb0426 encodes a 2'-deoxyribosyltransferase that plays a central role in purine salvage.

Lawrence KA, Jewett MW, Rosa PA, Gherardini FC.

Mol Microbiol. 2009 Jun;72(6):1517-29. doi: 10.1111/j.1365-2958.2009.06740.x. Epub 2009 May 15.

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