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Results: 1 to 20 of 204

1.

Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo.

Altmeppen HC, Prox J, Puig B, Kluth MA, Bernreuther C, Thurm D, Jorissen E, Petrowitz B, Bartsch U, De Strooper B, Saftig P, Glatzel M.

Mol Neurodegener. 2011 May 27;6:36. doi: 10.1186/1750-1326-6-36.

PMID:
21619641
[PubMed]
Free PMC Article
2.

Biology and pathophysiology of the amyloid precursor protein.

Zheng H, Koo EH.

Mol Neurodegener. 2011 Apr 28;6(1):27. doi: 10.1186/1750-1326-6-27.

PMID:
21527012
[PubMed]
Free PMC Article
3.

Reciprocal relationship between APP positioning relative to the membrane and PS1 conformation.

Uemura K, Farner KC, Nasser-Ghodsi N, Jones P, Berezovska O.

Mol Neurodegener. 2011 Feb 10;6(1):15. doi: 10.1186/1750-1326-6-15.

PMID:
21310068
[PubMed]
Free PMC Article
4.

Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit.

Gersbacher MT, Kim DY, Bhattacharyya R, Kovacs DM.

Mol Neurodegener. 2010 Dec 23;5:61. doi: 10.1186/1750-1326-5-61.

PMID:
21182789
[PubMed]
Free PMC Article
5.

Activation and intrinsic gamma-secretase activity of presenilin 1.

Ahn K, Shelton CC, Tian Y, Zhang X, Gilchrist ML, Sisodia SS, Li YM.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21435-40. doi: 10.1073/pnas.1013246107. Epub 2010 Nov 29.

PMID:
21115843
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ß production.

Bordji K, Becerril-Ortega J, Nicole O, Buisson A.

J Neurosci. 2010 Nov 24;30(47):15927-42. doi: 10.1523/JNEUROSCI.3021-10.2010.

PMID:
21106831
[PubMed - indexed for MEDLINE]
Free Article
7.

Identification of NEEP21 as a ß-amyloid precursor protein-interacting protein in vivo that modulates amyloidogenic processing in vitro.

Norstrom EM, Zhang C, Tanzi R, Sisodia SS.

J Neurosci. 2010 Nov 17;30(46):15677-85. doi: 10.1523/JNEUROSCI.4464-10.2010.

PMID:
21084623
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

BACE1 gene variants do not influence BACE1 activity, levels of APP or Aβ isoforms in CSF in Alzheimer's disease.

Sjölander A, Zetterberg H, Andreasson U, Minthon L, Blennow K.

Mol Neurodegener. 2010 Sep 17;5:37. doi: 10.1186/1750-1326-5-37.

PMID:
20849576
[PubMed]
Free PMC Article
9.

BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization.

Hitt BD, Jaramillo TC, Chetkovich DM, Vassar R.

Mol Neurodegener. 2010 Aug 23;5:31. doi: 10.1186/1750-1326-5-31.

PMID:
20731874
[PubMed]
Free PMC Article
10.

ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons.

Kuhn PH, Wang H, Dislich B, Colombo A, Zeitschel U, Ellwart JW, Kremmer E, Rossner S, Lichtenthaler SF.

EMBO J. 2010 Sep 1;29(17):3020-32. doi: 10.1038/emboj.2010.167. Epub 2010 Jul 30.

PMID:
20676056
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Transgenic expression of the amyloid-beta precursor protein-intracellular domain does not induce Alzheimer's Disease-like traits in vivo.

Giliberto L, d'Abramo C, Acker CM, Davies P, D'Adamio L.

PLoS One. 2010 Jul 16;5(7):e11609. doi: 10.1371/journal.pone.0011609.

PMID:
20661273
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein.

Dahms SO, Hoefgen S, Roeser D, Schlott B, Gührs KH, Than ME.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5381-6. doi: 10.1073/pnas.0911326107. Epub 2010 Mar 8. Erratum in: Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2629.

PMID:
20212142
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Substrate check of gamma-secretase.

Zhang YW, Xu H.

Nat Struct Mol Biol. 2010 Feb;17(2):140-1. doi: 10.1038/nsmb0210-140. No abstract available.

PMID:
20130572
[PubMed - indexed for MEDLINE]
14.

An APP inhibitory domain containing the Flemish mutation residue modulates gamma-secretase activity for Abeta production.

Tian Y, Bassit B, Chau D, Li YM.

Nat Struct Mol Biol. 2010 Feb;17(2):151-8. doi: 10.1038/nsmb.1743. Epub 2010 Jan 10.

PMID:
20062056
[PubMed - indexed for MEDLINE]
15.

Neurons generated from APP/APLP1/APLP2 triple knockout embryonic stem cells behave normally in vitro and in vivo: lack of evidence for a cell autonomous role of the amyloid precursor protein in neuronal differentiation.

Bergmans BA, Shariati SA, Habets RL, Verstreken P, Schoonjans L, Müller U, Dotti CG, De Strooper B.

Stem Cells. 2010 Mar 31;28(3):399-406. doi: 10.1002/stem.296.

PMID:
20049903
[PubMed - indexed for MEDLINE]
Free Article
16.

Alzheimer's disease: synaptic dysfunction and Abeta.

Shankar GM, Walsh DM.

Mol Neurodegener. 2009 Nov 23;4:48. doi: 10.1186/1750-1326-4-48.

PMID:
19930651
[PubMed]
Free PMC Article
17.

Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain.

Ghosal K, Vogt DL, Liang M, Shen Y, Lamb BT, Pimplikar SW.

Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18367-72. doi: 10.1073/pnas.0907652106. Epub 2009 Oct 16.

PMID:
19837693
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

A physiological role for amyloid-beta protein:enhancement of learning and memory.

Morley JE, Farr SA, Banks WA, Johnson SN, Yamada KA, Xu L.

J Alzheimers Dis. 2010;19(2):441-9. doi: 10.3233/JAD-2009-1230.

PMID:
19749407
[PubMed - indexed for MEDLINE]
19.

Maturation of BRI2 generates a specific inhibitor that reduces APP processing at the plasma membrane and in endocytic vesicles.

Matsuda S, Matsuda Y, Snapp EL, D'Adamio L.

Neurobiol Aging. 2011 Aug;32(8):1400-8. doi: 10.1016/j.neurobiolaging.2009.08.005. Epub 2009 Sep 12.

PMID:
19748705
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Statin's excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events, likely via rho-ROCK signaling.

Ma T, Zhao Y, Kwak YD, Yang Z, Thompson R, Luo Z, Xu H, Liao FF.

J Neurosci. 2009 Sep 9;29(36):11226-36. doi: 10.1523/JNEUROSCI.6150-08.2009.

PMID:
19741129
[PubMed - indexed for MEDLINE]
Free PMC Article

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