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Results: 1 to 20 of 39

1.

Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation.

Balagopalan L, Ashwell BA, Bernot KM, Akpan IO, Quasba N, Barr VA, Samelson LE.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2885-90. doi: 10.1073/pnas.1007098108. Epub 2011 Jan 31.

PMID:
21282648
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse.

Lasserre R, Charrin S, Cuche C, Danckaert A, Thoulouze MI, de Chaumont F, Duong T, Perrault N, Varin-Blank N, Olivo-Marin JC, Etienne-Manneville S, Arpin M, Di Bartolo V, Alcover A.

EMBO J. 2010 Jul 21;29(14):2301-14. doi: 10.1038/emboj.2010.127. Epub 2010 Jun 15.

PMID:
20551903
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Essential role of ubiquitin and TSG101 protein in formation and function of the central supramolecular activation cluster.

Vardhana S, Choudhuri K, Varma R, Dustin ML.

Immunity. 2010 Apr 23;32(4):531-40. doi: 10.1016/j.immuni.2010.04.005.

PMID:
20399684
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Bioinformatic and experimental survey of 14-3-3-binding sites.

Johnson C, Crowther S, Stafford MJ, Campbell DG, Toth R, MacKintosh C.

Biochem J. 2010 Mar 15;427(1):69-78. doi: 10.1042/BJ20091834.

PMID:
20141511
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Hematopoietic lineage cell-specific protein 1 is recruited to the immunological synapse by IL-2-inducible T cell kinase and regulates phospholipase Cgamma1 Microcluster dynamics during T cell spreading.

Carrizosa E, Gomez TS, Labno CM, Klos Dehring DA, Liu X, Freedman BD, Billadeau DD, Burkhardt JK.

J Immunol. 2009 Dec 1;183(11):7352-61. doi: 10.4049/jimmunol.0900973. Epub 2009 Nov 16.

PMID:
19917685
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Hematopoietic progenitor kinase 1 is a critical component of prostaglandin E2-mediated suppression of the anti-tumor immune response.

Alzabin S, Pyarajan S, Yee H, Kiefer F, Suzuki A, Burakoff S, Sawasdikosol S.

Cancer Immunol Immunother. 2010 Mar;59(3):419-29. doi: 10.1007/s00262-009-0761-0. Epub 2009 Sep 29.

PMID:
19787351
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activity.

Miletic AV, Graham DB, Sakata-Sogawa K, Hiroshima M, Hamann MJ, Cemerski S, Kloeppel T, Billadeau DD, Kanagawa O, Tokunaga M, Swat W.

PLoS One. 2009 Aug 12;4(8):e6599. doi: 10.1371/journal.pone.0006599.

PMID:
19672294
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility.

Wang H, Wei B, Bismuth G, Rudd CE.

Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12436-41. doi: 10.1073/pnas.0900510106. Epub 2009 Jul 15.

PMID:
19617540
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.

Brummer T, Larance M, Herrera Abreu MT, Lyons RJ, Timpson P, Emmerich CH, Fleuren ED, Lehrbach GM, Schramek D, Guilhaus M, James DE, Daly RJ.

EMBO J. 2008 Sep 3;27(17):2305-16.

PMID:
19172738
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Tailoring T-cell receptor signals by proximal negative feedback mechanisms.

Acuto O, Di Bartolo V, Michel F.

Nat Rev Immunol. 2008 Sep;8(9):699-712. doi: 10.1038/nri2397. Review.

PMID:
18728635
[PubMed - indexed for MEDLINE]
11.

T cell costimulation via the integrin VLA-4 inhibits the actin-dependent centralization of signaling microclusters containing the adaptor SLP-76.

Nguyen K, Sylvain NR, Bunnell SC.

Immunity. 2008 Jun;28(6):810-21. doi: 10.1016/j.immuni.2008.04.019.

PMID:
18549800
[PubMed - indexed for MEDLINE]
Free Article
12.

HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I.

Hung CH, Thomas L, Ruby CE, Atkins KM, Morris NP, Knight ZA, Scholz I, Barklis E, Weinberg AD, Shokat KM, Thomas G.

Cell Host Microbe. 2007 Apr 19;1(2):121-33.

PMID:
18005690
[PubMed - indexed for MEDLINE]
Free Article
13.

c-Cbl-mediated regulation of LAT-nucleated signaling complexes.

Balagopalan L, Barr VA, Sommers CL, Barda-Saad M, Goyal A, Isakowitz MS, Samelson LE.

Mol Cell Biol. 2007 Dec;27(24):8622-36. Epub 2007 Oct 15.

PMID:
17938199
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76.

Di Bartolo V, Montagne B, Salek M, Jungwirth B, Carrette F, Fourtane J, Sol-Foulon N, Michel F, Schwartz O, Lehmann WD, Acuto O.

J Exp Med. 2007 Mar 19;204(3):681-91. Epub 2007 Mar 12.

PMID:
17353368
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell-mediated immune responses.

Shui JW, Boomer JS, Han J, Xu J, Dement GA, Zhou G, Tan TH.

Nat Immunol. 2007 Jan;8(1):84-91. Epub 2006 Nov 19.

PMID:
17115060
[PubMed - indexed for MEDLINE]
16.

Direct observation of individual endogenous protein complexes in situ by proximity ligation.

Söderberg O, Gullberg M, Jarvius M, Ridderstråle K, Leuchowius KJ, Jarvius J, Wester K, Hydbring P, Bahram F, Larsson LG, Landegren U.

Nat Methods. 2006 Dec;3(12):995-1000. Epub 2006 Oct 29.

PMID:
17072308
[PubMed - indexed for MEDLINE]
17.

Persistence of cooperatively stabilized signaling clusters drives T-cell activation.

Bunnell SC, Singer AL, Hong DI, Jacque BH, Jordan MS, Seminario MC, Barr VA, Koretzky GA, Samelson LE.

Mol Cell Biol. 2006 Oct;26(19):7155-66.

PMID:
16980618
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

T-cell antigen receptor-induced signaling complexes: internalization via a cholesterol-dependent endocytic pathway.

Barr VA, Balagopalan L, Barda-Saad M, Polishchuk R, Boukari H, Bunnell SC, Bernot KM, Toda Y, Nossal R, Samelson LE.

Traffic. 2006 Sep;7(9):1143-62.

PMID:
16919152
[PubMed - indexed for MEDLINE]
19.

T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster.

Varma R, Campi G, Yokosuka T, Saito T, Dustin ML.

Immunity. 2006 Jul;25(1):117-27.

PMID:
16860761
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond.

Koretzky GA, Abtahian F, Silverman MA.

Nat Rev Immunol. 2006 Jan;6(1):67-78. Review.

PMID:
16493428
[PubMed - indexed for MEDLINE]
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