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Liver X receptor α activation with the synthetic ligand T0901317 reduces lung injury and inflammation after hemorrhage and resuscitation via inhibition of the nuclear factor κB pathway.

Solan PD, Piraino G, Hake PW, Denenberg A, O'Connor M, Lentsch A, Zingarelli B.

Shock. 2011 Apr;35(4):367-74. doi: 10.1097/SHK.0b013e3181f7d742.


Peroxisome proliferator-activated receptor {delta} regulates inflammation via NF-{kappa}B signaling in polymicrobial sepsis.

Zingarelli B, Piraino G, Hake PW, O'Connor M, Denenberg A, Fan H, Cook JA.

Am J Pathol. 2010 Oct;177(4):1834-47. doi: 10.2353/ajpath.2010.091010. Epub 2010 Aug 13.


Matrix metalloproteinase-8 inactivates macrophage inflammatory protein-1 alpha to reduce acute lung inflammation and injury in mice.

Quintero PA, Knolle MD, Cala LF, Zhuang Y, Owen CA.

J Immunol. 2010 Feb 1;184(3):1575-88. doi: 10.4049/jimmunol.0900290. Epub 2009 Dec 30.


Identification of pediatric septic shock subclasses based on genome-wide expression profiling.

Wong HR, Cvijanovich N, Lin R, Allen GL, Thomas NJ, Willson DF, Freishtat RJ, Anas N, Meyer K, Checchia PA, Monaco M, Odom K, Shanley TP.

BMC Med. 2009 Jul 22;7:34. doi: 10.1186/1741-7015-7-34.


Matrix metalloproteinases as drug targets in infections caused by gram-negative bacteria and in septic shock.

Vanlaere I, Libert C.

Clin Microbiol Rev. 2009 Apr;22(2):224-39, Table of Contents. doi: 10.1128/CMR.00047-08. Review.


Genomic expression profiling across the pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum.

Wong HR, Cvijanovich N, Allen GL, Lin R, Anas N, Meyer K, Freishtat RJ, Monaco M, Odoms K, Sakthivel B, Shanley TP; Genomics of Pediatric SIRS/Septic Shock Investigators.

Crit Care Med. 2009 May;37(5):1558-66. doi: 10.1097/CCM.0b013e31819fcc08.


Matrix metalloproteinase activity in pediatric acute lung injury.

Kong MY, Gaggar A, Li Y, Winkler M, Blalock JE, Clancy JP.

Int J Med Sci. 2009;6(1):9-17. Epub 2008 Dec 16.


Validating the genomic signature of pediatric septic shock.

Cvijanovich N, Shanley TP, Lin R, Allen GL, Thomas NJ, Checchia P, Anas N, Freishtat RJ, Monaco M, Odoms K, Sakthivel B, Wong HR; Genomics of Pediatric SIRS/Septic Shock Investigators.

Physiol Genomics. 2008 Jun 12;34(1):127-34. doi: 10.1152/physiolgenomics.00025.2008. Epub 2008 May 6.


Collagenase-2 deficiency or inhibition impairs experimental autoimmune encephalomyelitis in mice.

Folgueras AR, Fueyo A, García-Suárez O, Cox J, Astudillo A, Tortorella P, Campestre C, Gutiérrez-Fernández A, Fanjul-Fernández M, Pennington CJ, Edwards DR, Overall CM, López-Otín C.

J Biol Chem. 2008 Apr 4;283(14):9465-74. doi: 10.1074/jbc.M709522200. Epub 2008 Feb 1.


Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008.

Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, Calandra T, Dhainaut JF, Gerlach H, Harvey M, Marini JJ, Marshall J, Ranieri M, Ramsay G, Sevransky J, Thompson BT, Townsend S, Vender JS, Zimmerman JL, Vincent JL; International Surviving Sepsis Campaign Guidelines Committee; American Association of Critical-Care Nurses; American College of Chest Physicians; American College of Emergency Physicians; Canadian Critical Care Society; European Society of Clinical Microbiology and Infectious Diseases; European Society of Intensive Care Medicine; European Respiratory Society; International Sepsis Forum; Japanese Association for Acute Medicine; Japanese Society of Intensive Care Medicine; Society of Critical Care Medicine; Society of Hospital Medicine; Surgical Infection Society; World Federation of Societies of Intensive and Critical Care Medicine.

Crit Care Med. 2008 Jan;36(1):296-327. Erratum in: Crit Care Med. 2008 Apr;36(4):1394-6.


Genome-level longitudinal expression of signaling pathways and gene networks in pediatric septic shock.

Shanley TP, Cvijanovich N, Lin R, Allen GL, Thomas NJ, Doctor A, Kalyanaraman M, Tofil NM, Penfil S, Monaco M, Odoms K, Barnes M, Sakthivel B, Aronow BJ, Wong HR.

Mol Med. 2007 Sep-Oct;13(9-10):495-508.


Matrix metalloproteinases as modulators of inflammation.

Manicone AM, McGuire JK.

Semin Cell Dev Biol. 2008 Feb;19(1):34-41. Epub 2007 Jul 10. Review.


LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity.

Tester AM, Cox JH, Connor AR, Starr AE, Dean RA, Puente XS, López-Otín C, Overall CM.

PLoS One. 2007 Mar 21;2(3):e312.


Genome-level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome.

Wong HR, Shanley TP, Sakthivel B, Cvijanovich N, Lin R, Allen GL, Thomas NJ, Doctor A, Kalyanaraman M, Tofil NM, Penfil S, Monaco M, Tagavilla MA, Odoms K, Dunsmore K, Barnes M, Aronow BJ; Genomics of Pediatric SIRS/Septic Shock Investigators.

Physiol Genomics. 2007 Jul 18;30(2):146-55. Epub 2007 Mar 20.


Chemically modified tetracycline (COL-3) improves survival if given 12 but not 24 hours after cecal ligation and puncture.

Halter JM, Pavone LA, Steinberg JM, Gatto LA, DiRocco J, Landas S, Nieman GF.

Shock. 2006 Dec;26(6):587-91.


Extracellular heat shock protein-70 induces endotoxin tolerance in THP-1 cells.

Aneja R, Odoms K, Dunsmore K, Shanley TP, Wong HR.

J Immunol. 2006 Nov 15;177(10):7184-92.


Matrix metalloproteinase-8: cleavage can be decisive.

Van Lint P, Libert C.

Cytokine Growth Factor Rev. 2006 Aug;17(4):217-23. Epub 2006 Jul 3. Review.


Matrix metalloproteinases and matrix metalloproteinase inhibitors in acute lung injury.

Fligiel SE, Standiford T, Fligiel HM, Tashkin D, Strieter RM, Warner RL, Johnson KJ, Varani J.

Hum Pathol. 2006 Apr;37(4):422-30.


Nuclear factor-kappaB.

Zingarelli B.

Crit Care Med. 2005 Dec;33(12 Suppl):S414-6. Review. No abstract available.


Resistance of collagenase-2 (matrix metalloproteinase-8)-deficient mice to TNF-induced lethal hepatitis.

Van Lint P, Wielockx B, Puimège L, Noël A, López-Otin C, Libert C.

J Immunol. 2005 Dec 1;175(11):7642-9.

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